2024
Gray matters: ViT-GAN framework for identifying schizophrenia biomarkers linking structural MRI and functional network connectivity
Bi Y, Abrol A, Jia S, Sui J, Calhoun V. Gray matters: ViT-GAN framework for identifying schizophrenia biomarkers linking structural MRI and functional network connectivity. NeuroImage 2024, 297: 120674. PMID: 38851549, DOI: 10.1016/j.neuroimage.2024.120674.Peer-Reviewed Original ResearchFunctional network connectivityMedial prefrontal cortexBrain structuresFunctional network connectivity matricesPrefrontal cortexStructural MRINetwork connectivityGray matterSelf-attention mechanismGenerative adversarial networkDeep learning architectureBrain disordersDorsolateral prefrontal cortexResearch of schizophreniaNeural signal processingIdentified functional connectivityCross-domain analysisAttention mapsStructural biomarkersAdversarial networkLearning architectureDL-PFCICA algorithmSchizophrenia patientsHigh-dimensional fMRI data
2019
Choroid Plexus Enlargement and Allostatic Load in Schizophrenia
Zhou Y, Huang J, Zhang P, Fan F, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Feng W, Yuan Y, Yang F, Savransky A, Ryan M, Goldwaser E, Chiappelli J, Rowland L, Kochunov P, Tan Y, Hong L. Choroid Plexus Enlargement and Allostatic Load in Schizophrenia. Schizophrenia Bulletin 2019, 46: 722-731. PMID: 31603232, PMCID: PMC7147577, DOI: 10.1093/schbul/sbz100.Peer-Reviewed Original ResearchConceptsChoroid plexusHigher allostatic loadAllostatic loadSex-matched healthy controlsCentral nervous system abnormalitiesFirst-episode schizophrenia patientsChoroid plexus enlargementNervous system abnormalitiesTotal intracranial volumeHealthy controlsThalamus volumeLateral ventricleNeuroendocrine biomarkersSystem abnormalitiesAmygdala volumeSchizophrenia patientsBrain disordersInitial stabilizationIntracranial volumeStructural biomarkersPlexusBrain structuresPatientsSchizophreniaGroup differences
2016
Dendritic spine remodeling following early and late Rac1 inhibition after spinal cord injury: evidence for a pain biomarker
Zhao P, Hill M, Liu S, Chen L, Bangalore L, Waxman SG, Tan AM. Dendritic spine remodeling following early and late Rac1 inhibition after spinal cord injury: evidence for a pain biomarker. Journal Of Neurophysiology 2016, 115: 2893-2910. PMID: 26936986, PMCID: PMC4922610, DOI: 10.1152/jn.01057.2015.Peer-Reviewed Original ResearchConceptsSpinal cord injuryNeuropathic painDendritic spine dysgenesisDendritic spinesCord injurySpine dysgenesisDorsal horn neuronsSpine profilesDendritic spine remodelingEffective clinical translationSensory dysfunctionSignificant complicationsNociceptive systemPain biomarkersSpine remodelingClinical conditionsPreclinical studiesRac1 activityEffective treatmentPainDrug responsivenessStructural biomarkersDisease statesRac1 inhibitionBiomarkers
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