2019
2039-P: Age-Related Dysfunction of Brown Adipose Progenitor Cells
GRAJA A, GOHLKE S, SARAIVA L, SCHULZ T. 2039-P: Age-Related Dysfunction of Brown Adipose Progenitor Cells. Diabetes 2019, 68 DOI: 10.2337/db19-2039-p.Peer-Reviewed Original ResearchAged stem cellsStem cellsBrown adipogenesisAdipogenic stem cellsBrown adipose tissue of miceLipid accumulation capacityObesity-prone phenotypesBrown adipogenic differentiationCell-intrinsic defectsCell cycle inhibitors p16Brown adipocyte markersStem cell clonesIsolate stem cellsBrown adipocyte formationExtracellular matrix functionDevelopment of obesityFat-derived stem cellsCell-intrinsic pathwaysInactivation of p53Induction of cellular senescenceAge-related defectsCell cycle blockageUncoupling protein 1Adipose tissue of micePrimary risk factor
2014
Tissue‐Engineered Vascular Grafts Created From Human Induced Pluripotent Stem Cells
Sundaram S, One J, Siewert J, Teodosescu S, Zhao L, Dimitrievska S, Qian H, Huang AH, Niklason L. Tissue‐Engineered Vascular Grafts Created From Human Induced Pluripotent Stem Cells. Stem Cells Translational Medicine 2014, 3: 1535-1543. PMID: 25378654, PMCID: PMC4250208, DOI: 10.5966/sctm.2014-0065.Peer-Reviewed Original ResearchConceptsPluripotent stem cellsMesenchymal lineagesSmooth muscle cell differentiationMuscle cell differentiationStem cellsInduced pluripotent stem cellsNeural crest intermediateHuman induced pluripotent stem cellsMesenchymal progenitor cellsStem cell clonesCollagen-rich matrixCell differentiationVascular developmentHiPSC linesProgenitor cellsSmooth muscle cellsCell apoptosisHiPS cellsLineagesMesenchymal markersGeneration of graftMuscle cellsClonesTissue-engineered vascular graftsCells
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