2039-P: Age-Related Dysfunction of Brown Adipose Progenitor Cells
GRAJA A, GOHLKE S, SARAIVA L, SCHULZ T. 2039-P: Age-Related Dysfunction of Brown Adipose Progenitor Cells. Diabetes 2019, 68 DOI: 10.2337/db19-2039-p.Peer-Reviewed Original ResearchAged stem cellsStem cellsBrown adipogenesisAdipogenic stem cellsBrown adipose tissue of miceLipid accumulation capacityObesity-prone phenotypesBrown adipogenic differentiationCell-intrinsic defectsCell cycle inhibitors p16Brown adipocyte markersStem cell clonesIsolate stem cellsBrown adipocyte formationExtracellular matrix functionDevelopment of obesityFat-derived stem cellsCell-intrinsic pathwaysInactivation of p53Induction of cellular senescenceAge-related defectsCell cycle blockageUncoupling protein 1Adipose tissue of micePrimary risk factor
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