Multiomics Analysis and Systems Biology Integration Identifies the Roles of IL-9 in Keratinocyte Metabolic Reprogramming
Marathe S, Dhamija B, Kumar S, Jain N, Ghosh S, Dharikar J, Srinivasan S, Das S, Sawant A, Desai S, Khan F, Syiemlieh A, Munde M, Nayak C, Gandhi M, Kumar A, Srivastava S, Venkatesh K, Barthel S, Purwar R. Multiomics Analysis and Systems Biology Integration Identifies the Roles of IL-9 in Keratinocyte Metabolic Reprogramming. Journal Of Investigative Dermatology 2021, 141: 1932-1942. PMID: 33667432, DOI: 10.1016/j.jid.2021.02.013.Peer-Reviewed Original ResearchConceptsMetabolic reprogrammingHuman primary keratinocytesIL-9Production of tricarboxylic acid cycle intermediatesRedirection of metabolic fluxIntegration of multiomics dataCentral carbohydrate metabolismElectron transport chain proteinsPrimary keratinocytesHigh-throughput quantitative proteomicsTricarboxylic acid cycle intermediatesStable isotope metabolomicsNuclear magnetic resonance-based metabolomicsElectron transport chainSystems-level analysisIL-9-producing T cellsPathogenesis of inflammatory disordersMetabolic fluxIncreased glucose consumptionIL-9 signalingTransport chainQuantitative proteomicsMultiomics dataCycle intermediatesMultiomics analysis
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