Catalytic Enantioselective Sulfur Alkylation of Sulfenamides for the Asymmetric Synthesis of Sulfoximines
Greenwood NS, Champlin AT, Ellman JA. Catalytic Enantioselective Sulfur Alkylation of Sulfenamides for the Asymmetric Synthesis of Sulfoximines. Journal Of The American Chemical Society 2022, 144: 17808-17814. PMID: 36154032, PMCID: PMC9650615, DOI: 10.1021/jacs.2c09158.Peer-Reviewed Original ResearchConceptsAsymmetric synthesisAlkylation productsChiral sulfur centerChiral rhodium catalystNew asymmetric synthesisDifferent binding interactionsChiral sulfoximinesChallenging preparationDiazo compoundsRhodium catalystSingle enantiomerNitrogen substituentsSulfur centerMild conditionsSulfur alkylationBinding interactionsRacemic mixtureDrug discoveryEnantiomeric ratioAlkylationHigh yieldsComplete retentionSynthesisKey stepEnantiomers
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