2021
The microRNA-195 - BDNF pathway and cognitive deficits in schizophrenia patients with minimal antipsychotic medication exposure
Pan S, Feng W, Li Y, Huang J, Chen S, Cui Y, Tian B, Tan S, Wang Z, Yao S, Chiappelli J, Kochunov P, Chen S, Yang F, Li CR, Tian L, Tan Y, Elliot Hong L. The microRNA-195 - BDNF pathway and cognitive deficits in schizophrenia patients with minimal antipsychotic medication exposure. Translational Psychiatry 2021, 11: 117. PMID: 33558459, PMCID: PMC7870897, DOI: 10.1038/s41398-021-01240-x.Peer-Reviewed Original ResearchConceptsBDNF protein levelsBrain-derived neurotrophic factorAntipsychotic medication exposureBDNF protein expressionMATRICS Consensus Cognitive BatteryMiR-195Medication exposureBDNF mRNABDNF proteinCognitive functionProtein levelsCognitive impairmentLower BDNF protein levelsCognitive deficitsSex-matched healthy controlsProtein expressionSubgroup of patientsFirst-episode patientsMiR-195 expressionBDNF reductionMedication-naïveNeurotrophic factorPeripheral bloodHealthy controlsOverall cognitive performance
2019
Theobromine Improves Working Memory by Activating the CaMKII/CREB/BDNF Pathway in Rats
Islam R, Matsuzaki K, Sumiyoshi E, Hossain E, Hashimoto M, Katakura M, Sugimoto N, Shido O. Theobromine Improves Working Memory by Activating the CaMKII/CREB/BDNF Pathway in Rats. Nutrients 2019, 11: 888. PMID: 31010016, PMCID: PMC6520707, DOI: 10.3390/nu11040888.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain-Derived Neurotrophic FactorCacaoCalcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP Response Element-Binding ProteinDietary SupplementsMaleMaze LearningMemory, Short-TermPhosphorylationPhytotherapyPlant ExtractsRats, WistarRNA, MessengerSignal TransductionTheobromineConceptsCREB/BDNF pathwayBrain-derived neurotropic factorMedial prefrontal cortexCAMP response element-binding proteinBDNF pathwayTB ratsCN ratsNovel object recognition testPhosphorylated cAMP response element-binding proteinY-maze testMale Wistar ratsEffect of theobromineObject recognition testRadial arm maze taskEnzyme-linked immunosorbentPrimary methylxanthineBDNF levelsBDNF proteinNeurotropic factorNormal dietReal-time PCRWistar ratsDifferent brain processesElement-binding proteinP-CaMKII
2009
Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction
Gourley SL, Howell JL, Rios M, DiLeone RJ, Taylor JR. Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction. Learning & Memory 2009, 16: 756-760. PMID: 19926781, PMCID: PMC2788209, DOI: 10.1101/lm.1547909.Peer-Reviewed Original Research
2002
Brain-Derived Neurotrophic Factor: A Novel Human Ovarian Follicular Protein
Seifer DB, Feng B, Shelden RM, Chen S, Dreyfus CF. Brain-Derived Neurotrophic Factor: A Novel Human Ovarian Follicular Protein. The Journal Of Clinical Endocrinology & Metabolism 2002, 87: 655-659. PMID: 11836300, DOI: 10.1210/jcem.87.2.8213.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorOocyte maturationSecretion of BDNFSource of BDNFNervous systemRelease of BDNFSoluble polypeptide growth factorsHuman ovarian folliclesHuman follicular fluidCumulus granulosa cellsMammalian nervous systemFollicular proteinsBDNF receptorOocyte retrievalBDNF proteinTrk BNeurotrophic factorPolypeptide growth factorsHuman ovaryMural granulosaFollicular fluidMouse oocyte maturationOvarian folliclesGranulosa cellsEndocrine tissues
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