2021
An update: the emerging evidence of complement involvement in COVID-19
Li Q, Chen Z. An update: the emerging evidence of complement involvement in COVID-19. Medical Microbiology And Immunology 2021, 210: 101-109. PMID: 33811541, PMCID: PMC8019074, DOI: 10.1007/s00430-021-00704-7.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeCOVID-19 patientsCOVID-19Pre-clinical samplesRespiratory distress syndromePotential treatment optionCoronavirus disease 2019Host immune responseMultiorgan failureComplement involvementSystemic inflammationDistress syndromeSevere patientsOrgan damageKidney failureTreatment optionsInflammatory responseTissue injuryDisease 2019Immune responseAnimal modelsMultiple organsAbnormal activationInnate immunityComplement inhibitorsTime-resolved systems immunology reveals a late juncture linked to fatal COVID-19
Liu C, Martins AJ, Lau WW, Rachmaninoff N, Chen J, Imberti L, Mostaghimi D, Fink DL, Burbelo PD, Dobbs K, Delmonte OM, Bansal N, Failla L, Sottini A, Quiros-Roldan E, Han K, Sellers BA, Cheung F, Sparks R, Chun TW, Moir S, Lionakis MS, Consortium N, Abers M, Apps R, Bosticardo M, Milanez-Almeida P, Mulè M, Shaw E, Zhang Y, Clinicians C, Castelli F, Muiesan M, Tomasoni G, Scolari F, Tucci A, Rossi C, Su H, Kuhns D, Cohen J, Notarangelo L, Tsang J. Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19. Cell 2021, 184: 1836-1857.e22. PMID: 33713619, PMCID: PMC7874909, DOI: 10.1016/j.cell.2021.02.018.Peer-Reviewed Original ResearchConceptsFatal COVID-19Peripheral immune cellsPlasmacytoid dendritic cellsPost-symptom onsetCOVID-19 patientsCOVID-19Fatty acid metabolismGene expression signaturesNK cellsSymptom onsetDendritic cellsSevere patientsFatal outcomeImmune response variationCellular inflammationImmune cellsInflammatory responseCell receptor sequencesExtensive patientClinical monitoringTherapeutic interventionsCell activationDay 17Disease severitySigns of exhaustion
2020
COVID-19 in South Korea: epidemiological and spatiotemporal patterns of the spread and the role of aggressive diagnostic tests in the early phase
Lee W, Hwang SS, Song I, Park C, Kim H, Song IK, Choi HM, Prifti K, Kwon Y, Kim J, Oh S, Yang J, Cha M, Kim Y, Bell ML, Kim H. COVID-19 in South Korea: epidemiological and spatiotemporal patterns of the spread and the role of aggressive diagnostic tests in the early phase. International Journal Of Epidemiology 2020, 49: 1106-1116. PMID: 32754756, PMCID: PMC7454567, DOI: 10.1093/ije/dyaa119.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBetacoronavirusChildChild, PreschoolClinical Laboratory TechniquesCoronavirusCoronavirus InfectionsCOVID-19COVID-19 TestingDiagnostic Tests, RoutineDisease OutbreaksHumansInfantInfant, NewbornMiddle AgedMortalityPandemicsPneumonia, ViralRepublic of KoreaSARS-CoV-2Spatio-Temporal AnalysisConceptsCOVID-19Aggressive diagnostic testsCase fatality rateNovel coronavirus disease (COVID-19) outbreakWidespread diagnostic testingEpidemic doubling timeSevere patientsCoronavirus disease (COVID-19) outbreakPatient care systemsInitial RTFatality rateTreatment policyDiagnostic testingFatality patternsDiagnostic testsDaily reproduction numberCare systemUnprecedented pandemicAggressive testingEarly epidemic phaseMedical resourcesEpidemic phaseEarly phaseDaysDisease outbreaksSeven recommendations to rescue the patients and reduce the mortality from COVID-19 infection: An immunological point of view
Kronbichler A, Effenberger M, Eisenhut M, Lee K, Shin J. Seven recommendations to rescue the patients and reduce the mortality from COVID-19 infection: An immunological point of view. Autoimmunity Reviews 2020, 19: 102570. PMID: 32376397, PMCID: PMC7252097, DOI: 10.1016/j.autrev.2020.102570.Peer-Reviewed Original ResearchConceptsImmunological pointManagement of patientsCOVID-19 infectionReduce morbiditySevere patientsCytokine stormTherapeutic approachesNo treatmentPatientsSevere symptomsImmunological reactionsMortalityMorbidityCOVID-19Severe public health emergencyPublic health emergencySymptomsTreatmentHealth emergency
2004
Prize reinforcement contingency management for treating cocaine users: how low can we go, and with whom?
Petry NM, Tedford J, Austin M, Nich C, Carroll KM, Rounsaville BJ. Prize reinforcement contingency management for treating cocaine users: how low can we go, and with whom? Addiction 2004, 99: 349-360. PMID: 14982548, PMCID: PMC3709247, DOI: 10.1111/j.1360-0443.2003.00642.x.Peer-Reviewed Original ResearchConceptsStandard treatmentUrinalysis resultsNegative urinalysis resultsCM conditionCommunity-based treatment centersPositive urinalysis resultsCommunity-based settingsContingency management interventionSevere patientsNegative urine samplesTreatment periodCM interventionPatientsTreatment centersMore abstinenceDrug useCocaine useTreatment assignmentBeneficial effectsUrine samplesCocaine usersContingency managementTreatmentInterventionGoal-related activities
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