2013
Successful Nonoperative Management of the Most Severe Blunt Renal Injuries: A Multicenter Study of the Research Consortium of New England Centers for Trauma
van der Wilden GM, Velmahos GC, Joseph DK, Jacobs L, DeBusk MG, Adams CA, Gross R, Burkott B, Agarwal S, Maung AA, Johnson DC, Gates J, Kelly E, Michaud Y, Charash WE, Winchell RJ, Desjardins SE, Rosenblatt MS, Gupta S, Gaeta M, Chang Y, de Moya MA. Successful Nonoperative Management of the Most Severe Blunt Renal Injuries: A Multicenter Study of the Research Consortium of New England Centers for Trauma. JAMA Surgery 2013, 148: 924-931. PMID: 23945834, DOI: 10.1001/jamasurg.2013.2747.Peer-Reviewed Original ResearchConceptsBlunt renal injuriesNonoperative managementNOM failureRenal injuryGrade IVFailure of NOMSevere blunt renal injuryRenal salvage rateSevere renal injuryRetrospective case seriesUrinary tract infectionMechanism of injurySuccessful nonoperative managementYears of ageRoad traffic crashesHemodynamic instabilityKidney injuryAdult patientsRenal failureStable patientsTract infectionsIndependent predictorsSalvage rateCase seriesNonoperative approach
1998
Reversal of Established Rat Crescentic Glomerulonephritis by Blockade of Macrophage Migration Inhibitory Factor (MIF): Potential Role of MIF in Regulating Glucocorticoid Production
Yang N, Nikolic-Paterson D, Ng Y, Mu W, Metz C, Bacher M, Meinhardt A, Bucala R, Atkins R, Lan H. Reversal of Established Rat Crescentic Glomerulonephritis by Blockade of Macrophage Migration Inhibitory Factor (MIF): Potential Role of MIF in Regulating Glucocorticoid Production. Molecular Medicine 1998, 4: 413-424. PMID: 10780884, PMCID: PMC2230272, DOI: 10.1007/bf03401748.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorCrescentic glomerulonephritisDay 7Ab treatmentRenal functionControl AbInhibitory factorPotent pro-inflammatory cytokineEndogenous glucocorticoid levelsIsotype control AbSevere renal injuryNormal renal functionCellular immune responsesPro-inflammatory cytokinesReversal of diseaseSerum corticosterone levelsExperimental crescentic glomerulonephritisInterleukin-1 productionRat crescentic glomerulonephritisCrescentic diseaseProgressive glomerulonephritisRenal injuryGBM glomerulonephritisLeukocyte infiltration
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