2022
P079Etonogestrel contraceptive implant users can experience breakthrough ovulation with only two weeks of exposure to a strong cyp3a inducer
Lazorwitz A, Teal S, Sheeder J. P079Etonogestrel contraceptive implant users can experience breakthrough ovulation with only two weeks of exposure to a strong cyp3a inducer. Contraception 2022, 116: 92. DOI: 10.1016/j.contraception.2022.09.103.Peer-Reviewed Original ResearchStrong CYP3A inducersBreakthrough ovulationCYP3A inducersE2 concentrationsP4 concentrationsMedian ageOvulation suppressionImplant usersPg/Baseline serum concentrationsContraceptive implant usersEtonogestrel implant usersSerum E2 concentrationsParticipants' median ageSerum P4 concentrationsENG implant usersDrug-drug interactionsRifampin exposureMedian durationENG implantMedian BMIEndogenous estradiolSerum concentrationsSurrogate biomarkerWeeks of exposure
2020
Associations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women’s Health Across the Nation
Ding N, Harlow S, Randolph J, Calafat A, Mukherjee B, Batterman S, Gold E, Park S. Associations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women’s Health Across the Nation. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa303. PMID: 32491182, PMCID: PMC7418447, DOI: 10.1210/clinem/dgaa303.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthNatural menopauseHazard ratioSerum concentrationsWomen's healthCohort of midlife womenConfidence intervalsCalculate hazard ratiosAdverse health outcomesPFAS serum concentrationsMonths of amenorrheaAssociation of perfluoroalkyl substancesEarly natural menopauseBaseline serum concentrationsCox proportional hazards modelsAssociated with earlier natural menopauseIsotope dilution tandem mass spectrometryHealth outcomesProportional hazards modelReverse causationBleeding episodesMidlife womenLowest tertileMedian timeHormone use
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