REDOMA: Bayesian random‐effects dose‐optimization meta‐analysis using spike‐and‐slab priors
Yang C, Kwiatkowski E, Lee J, Lin R. REDOMA: Bayesian random‐effects dose‐optimization meta‐analysis using spike‐and‐slab priors. Statistics In Medicine 2024, 43: 3484-3502. PMID: 38857904, PMCID: PMC11789924, DOI: 10.1002/sim.10107.Peer-Reviewed Original ResearchConceptsOptimal biological doseDose-efficacy curveDose efficacyPhase I/II trialMeta-analysisOncology trialsSpike-and-slabMultiple phase IDose-toxicity relationshipPrecision cancer treatmentEarly-phase oncology trialsOncological therapyBiological doseEfficacy dataSpike-and-slab priorsTreatment efficacyCancer treatmentExtensive simulation studyTrialsEfficacyBayesian model selection frameworkTreatmentPhase IDoseGamma process
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