2016
Enhancement of DEN-induced liver tumorigenesis in heme oxygenase-1 G143H mutant transgenic mice
Jin J, Wang D, Xiao H, Wei H, Matunda C, Zhang H, Li X, Wang C, Zou C, Gao X, Zhao W, Li Q. Enhancement of DEN-induced liver tumorigenesis in heme oxygenase-1 G143H mutant transgenic mice. Biochemical And Biophysical Research Communications 2016, 481: 169-175. PMID: 27810363, DOI: 10.1016/j.bbrc.2016.10.148.Peer-Reviewed Original ResearchConceptsHO-1Susceptibility to DEN-induced hepatocarcinogenesisTransgenic miceHO-1 promoter polymorphismSecretion of inflammatory cytokinesDEN-induced hepatocarcinogenesisMutant transgenic miceHeme oxygenaseProgression of tumorigenesisAnti-inflammatory functionsPromoter polymorphismTumor growthInflammatory cytokinesDominant negative mutantEnhancement of ROS productionLiver carcinogenesisLiver tumorigenesisHepatocyte deathGrowing body of evidenceBody of evidenceTumorigenesisProtective roleROS productionNegative mutantMice
2013
Location, location, location: tissue-specific regulation of immune responses
Hu W, Pasare C. Location, location, location: tissue-specific regulation of immune responses. Journal Of Leukocyte Biology 2013, 94: 409-421. PMID: 23825388, PMCID: PMC3747123, DOI: 10.1189/jlb.0413207.Peer-Reviewed Original ResearchConceptsImmune responseOutcome of adaptive immunityStromal cellsImmune systemOutcome of immune responsesInduction of innateAntigen-specific TAdaptive immune cellsAdaptive-immune responsesActivation of PRRRegulation of immune responsesSecretion of inflammatory cytokinesMucosal immune systemAdaptive immune responsesTissue-specific factorsImmune cellsInflammatory cytokinesReceptor activationAdaptive immunityTissue-specific regulationCommensal microbiotaPhenotypic heterogeneityImmune challengeInnateSignaling events
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