2025
Tissue‐Resident T Cells That Promote Humoral Immunity: Emerging From the Shadow of T Follicular Helper Cells
Chen S, Craft J. Tissue‐Resident T Cells That Promote Humoral Immunity: Emerging From the Shadow of T Follicular Helper Cells. Immunological Reviews 2025, 334: e70056. PMID: 40890948, PMCID: PMC12402542, DOI: 10.1111/imr.70056.Peer-Reviewed Original ResearchConceptsB cell folliclesB cell maturationHelper cellsT cellsB cellsB-cell follicles of secondary lymphoid organsFollicles of secondary lymphoid organsT follicular helper (Tfh) cellsHumoral immunityRegulate B-cell maturationTissue-resident T cellsT Follicular Helper CellsFunction of T cellsAntibody-producing plasma cellsB cell helpDevelopment of humoral immunitySecondary lymphoid organsLocal humoral responseNon-lymphoid tissuesHumoral immune responseImmune challengeSystemic immune protectionCentral nervous systemTfh cellsImmunoglobulin class switch recombination
2024
nf-core/airrflow: An adaptive immune receptor repertoire analysis workflow employing the Immcantation framework.
Gabernet G, Marquez S, Bjornson R, Peltzer A, Meng H, Aron E, Lee N, Jensen C, Ladd D, Polster M, Hanssen F, Heumos S, Yaari G, Kowarik M, Nahnsen S, Kleinstein S. nf-core/airrflow: An adaptive immune receptor repertoire analysis workflow employing the Immcantation framework. PLOS Computational Biology 2024, 20: e1012265. PMID: 39058741, PMCID: PMC11305553, DOI: 10.1371/journal.pcbi.1012265.Peer-Reviewed Original ResearchImmcantation frameworkAIRR-seqAIRR-seq dataAdaptive immune receptor repertoire sequencingSingle-cell sequencing datasetsClonal inferenceSequencing errorsSequencing datasetsNextflow workflowClonal relationshipReceptor sequencesRepertoire sequencingHigh-throughput processingSequenceImmune challengeAnalysis workflowT-cell receptor sequencingNextflowB cellsSARS-CoV-2Experimental toolResponse to SARS-CoV-2Infectious diseases
2021
CD4+ T cells that help B cells – a proposal for uniform nomenclature
Eisenbarth SC, Baumjohann D, Craft J, Fazilleau N, Ma CS, Tangye SG, Vinuesa CG, Linterman MA. CD4+ T cells that help B cells – a proposal for uniform nomenclature. Trends In Immunology 2021, 42: 658-669. PMID: 34244056, PMCID: PMC8324560, DOI: 10.1016/j.it.2021.06.003.Peer-Reviewed Original ResearchConceptsTfh-like cellsB cellsT cellsFollicular helper cellsAntigen-primed B cellsSecondary lymphoid tissuesTranscription factor Bcl6B cell differentiationHelper cellsHumoral immunityLymphoid tissueChemokine receptorsAnatomical sitesImmune challengeDistinct subsetsDifferent isotypesCD4TfhCellular plasticityCellsCell differentiationUniform nomenclatureCytokinesImmunityAntibodiesT Follicular Regulatory Cells: Choreographers of Productive Germinal Center Responses
Lu Y, Craft J. T Follicular Regulatory Cells: Choreographers of Productive Germinal Center Responses. Frontiers In Immunology 2021, 12: 679909. PMID: 34177925, PMCID: PMC8222975, DOI: 10.3389/fimmu.2021.679909.Peer-Reviewed Original ResearchConceptsTfr cellsTreg cellsHumoral immunityGerminal centersAntigen-specific B cell responsesFollicular helper cellsFollicular regulatory (Tfr) cellsB cell folliclesRegulatory T cellsB cell autoreactivityB cell responsesGerminal center responseB cell toleranceVaccine design strategiesTranscription factor Bcl6Regulatory cellsHelper cellsImmune homeostasisProductive immunityT cellsViral infectionCenter responseCell responsesGC responseImmune challenge
2014
High-resolution antibody dynamics of vaccine-induced immune responses
Laserson U, Vigneault F, Gadala-Maria D, Yaari G, Uduman M, Vander Heiden J, Kelton W, Jung S, Liu Y, Laserson J, Chari R, Lee JH, Bachelet I, Hickey B, Lieberman-Aiden E, Hanczaruk B, Simen BB, Egholm M, Koller D, Georgiou G, Kleinstein SH, Church GM. High-resolution antibody dynamics of vaccine-induced immune responses. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 4928-4933. PMID: 24639495, PMCID: PMC3977259, DOI: 10.1073/pnas.1323862111.Peer-Reviewed Original Research
2013
Location, location, location: tissue-specific regulation of immune responses
Hu W, Pasare C. Location, location, location: tissue-specific regulation of immune responses. Journal Of Leukocyte Biology 2013, 94: 409-421. PMID: 23825388, PMCID: PMC3747123, DOI: 10.1189/jlb.0413207.Peer-Reviewed Original ResearchConceptsImmune responseOutcome of adaptive immunityStromal cellsImmune systemOutcome of immune responsesInduction of innateAntigen-specific TAdaptive immune cellsAdaptive-immune responsesActivation of PRRRegulation of immune responsesSecretion of inflammatory cytokinesMucosal immune systemAdaptive immune responsesTissue-specific factorsImmune cellsInflammatory cytokinesReceptor activationAdaptive immunityTissue-specific regulationCommensal microbiotaPhenotypic heterogeneityImmune challengeInnateSignaling eventsRelationships between biomarkers of inflammation, ovarian steroids, and age at menarche in a rural polish sample
Clancy K, Klein L, Ziomkiewicz A, Nenko I, Jasienska G, Bribiescas R. Relationships between biomarkers of inflammation, ovarian steroids, and age at menarche in a rural polish sample. American Journal Of Human Biology 2013, 25: 389-398. PMID: 23606228, DOI: 10.1002/ajhb.22386.Peer-Reviewed Original ResearchConceptsBiomarkers of inflammationMenstrual cycleLowest CRP tertileOvarian hormone concentrationsAge of menarcheHigh CRPOvarian suppressionCRP tertileTiming of menarcheOvarian hormonesOvarian steroidsOvarian functionInverse associationLow progesteroneHormone concentrationsStrong negative predictorSalivary progesteroneRecall methodInflammatory sensitivityCRPMenarcheInflammationImmune challengeEstradiolNegative predictor
2007
Refractoriness in Tsetse Flies (Diptera: Glossinidae) May be a Matter of Timing
Nayduch D, Aksoy S. Refractoriness in Tsetse Flies (Diptera: Glossinidae) May be a Matter of Timing. Journal Of Medical Entomology 2007, 44: 660-665. DOI: 10.1603/0022-2585%282007%2944%5b660%3aritfdg%5d2.0.co%3b2.Peer-Reviewed Original ResearchAttacin expressionTsetse fliesReverse geneticsRNA interferenceFly speciesGene expressionAttacinCertain speciesSusceptible speciesBlood feedingSpeciesVector competenceFliesImmune challengeEfficient vectorSusceptible fliesDevastating diseaseExpressionRefractory speciesTsetseG. pallidipesAfrican trypanosomiasisHumoral immune responseSalivary glandsRepressionRefractoriness in Tsetse Flies (Diptera: Glossinidae) May be a Matter of Timing
Nayduch D, Aksoy S. Refractoriness in Tsetse Flies (Diptera: Glossinidae) May be a Matter of Timing. Journal Of Medical Entomology 2007, 51 DOI: 10.1603/0022-2585(2007)44[660:ritfdg]2.0.co;2.Peer-Reviewed Original ResearchAttacin expressionTsetse fliesReverse geneticsRNA interferenceFly speciesGene expressionAttacinCertain speciesSusceptible speciesBlood feedingSpeciesVector competenceFliesImmune challengeEfficient vectorDevastating diseaseExpressionRefractory speciesTsetseG. pallidipesAfrican trypanosomiasisHumoral immune responseSalivary glandsRepressionDisease transmission
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