Pathogenesis and promising therapeutics of Alzheimer disease through eIF2α pathway and correspondent kinases
Moradi Majd R, Mayeli M, Rahmani F. Pathogenesis and promising therapeutics of Alzheimer disease through eIF2α pathway and correspondent kinases. Metabolic Brain Disease 2020, 35: 1241-1250. PMID: 32681467, DOI: 10.1007/s11011-020-00600-8.Peer-Reviewed Original ResearchConceptsHeme-regulated inhibitor kinasePKR-like endoplasmic reticulum kinaseActivating Transcription Factor 4Double-stranded RNA-activated protein kinasePathological hallmarks of ADEukaryotic initiation factor 2RNA-activated protein kinaseInitiation factor 2Hallmarks of ADRegulation of protein synthesisEndoplasmic reticulum kinaseAlzheimer's diseaseBeta-amyloidogenesisSer-51Transcription factor 4Tau phosphorylationEukaryotic cellsTherapeutics of Alzheimer's diseaseB-secretaseProtein kinasePathway inductionPathological hallmarkKinaseProtein synthesisPhosphorylation
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