Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling
Y C, Marioni J, Griffiths G, Richard A. Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling. ELife 2020, 9: e53948. PMID: 32412411, PMCID: PMC7308083, DOI: 10.7554/elife.53948.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesCells, CulturedFemaleFlow CytometryInterferon Regulatory FactorsKineticsLigandsLymphocyte ActivationMaleMice, Inbred C57BLMice, TransgenicNuclear Receptor Subfamily 4, Group A, Member 1OvalbuminPeptide FragmentsPhosphorylationReceptors, Antigen, T-CellRibosomal Protein S6Signal TransductionSingle-Cell AnalysisConceptsT cellsMurine CD8<sup>+</sup> T cellsStrength of TCR stimulationCD8<sup>+</sup> T cellsDistal signaling eventsStimulation strengthTCR-induced signalsNaive T cellsMultiple signaling pathwaysT cell activationRibosomal protein S6Signaling eventsPeptide-MHC ligandsIntracellular machineryTCR stimulationProtein S6Signaling pathwayMass cytometrySignaling resultsStimulationMolecular organizationTranscription
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