2017
Heat-induced-radiolabeling and click chemistry: A powerful combination for generating multifunctional nanomaterials
Yuan H, Wilks M, Fakhri G, Normandin M, Kaittanis C, Josephson L. Heat-induced-radiolabeling and click chemistry: A powerful combination for generating multifunctional nanomaterials. PLOS ONE 2017, 12: e0172722. PMID: 28225818, PMCID: PMC5321420, DOI: 10.1371/journal.pone.0172722.Peer-Reviewed Original ResearchConceptsClick reactionClick chemistryCopper-free click reactionCopper-CatalyzedAzide groupsBiomolecule attachmentReporter groupNP surfaceTargeted nanoparticlesNanoparticlesBioactive groupsMultifunctional nanomaterialsBiomedical applicationsSynthesisIntermediateReactionChemistryNanomaterialsBiomoleculesAlkynesCombination of techniquesCell surface receptorsAzideTherapeutic agentsClick
2016
Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes
Bordenave T, Helle M, Beau F, Georgiadis D, Tepshi L, Bernes M, Ye Y, Levenez L, Poquet E, Nozach H, Razavian M, Toczek J, Stura EA, Dive V, Sadeghi MM, Devel L. Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes. Bioconjugate Chemistry 2016, 27: 2407-2417. PMID: 27564088, PMCID: PMC5100701, DOI: 10.1021/acs.bioconjchem.6b00377.Peer-Reviewed Original ResearchConceptsDye moietyLinker lengthSelective optical probeVivo performanceDye structureFirst crystal structureCyanine dyesHydrophilic characterSeries of tracersSelective probeReporter groupCrystal structureNovel seriesBlood clearance rateFluorescent probePseudopeptide inhibitorsWhole conjugateNet chargeMoietyCrystallographic structureSelectivity profileSmall peptidesOptical probeVivo behaviorVivo evaluation
2015
Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP
Baguley TD, Nairn AC, Lombroso PJ, Ellman JA. Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP. Bioorganic & Medicinal Chemistry Letters 2015, 25: 1044-1046. PMID: 25666825, PMCID: PMC4334692, DOI: 10.1016/j.bmcl.2015.01.020.Peer-Reviewed Original ResearchConceptsStriatal-enriched protein tyrosine phosphataseProtein tyrosine phosphataseTyrosine phosphataseSpecific protein tyrosine phosphataseInhibitor potencyNeurodegenerative diseasesPotent inhibitorReporter groupPhosphataseStructural featuresInhibitorsConvenient handleSubstitutionAlzheimer's diseaseCellsInhibition
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