Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP
Baguley TD, Nairn AC, Lombroso PJ, Ellman JA. Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP. Bioorganic & Medicinal Chemistry Letters 2015, 25: 1044-1046. PMID: 25666825, PMCID: PMC4334692, DOI: 10.1016/j.bmcl.2015.01.020.Peer-Reviewed Original ResearchConceptsStriatal-enriched protein tyrosine phosphataseProtein tyrosine phosphataseTyrosine phosphataseSpecific protein tyrosine phosphataseInhibitor potencyNeurodegenerative diseasesPotent inhibitorReporter groupPhosphataseStructural featuresInhibitorsConvenient handleSubstitutionAlzheimer's diseaseCellsInhibition
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