2012
Synchronous Resection of Primary and Liver Metastases for Neuroendocrine Tumors
Gaujoux S, Gonen M, Tang L, Klimstra D, Brennan M, D’Angelica M, DeMatteo R, Allen P, Jarnagin W, Fong Y. Synchronous Resection of Primary and Liver Metastases for Neuroendocrine Tumors. Annals Of Surgical Oncology 2012, 19: 4270-4277. PMID: 22752376, DOI: 10.1245/s10434-012-2462-8.Peer-Reviewed Original ResearchConceptsNeuroendocrine tumorsLiver metastasesSynchronous resectionSimultaneous resection of liver metastasesResection of liver metastasesRecurrent neuroendocrine tumorLiver-directed therapiesMetastatic neuroendocrine tumorsLiver metastasis resectionPrimary neuroendocrine tumorsMedian Follow-UpSymptom-free survivalLong-term outcomesMedian sizePrimary/recurrent tumorMetastasis resectionSimultaneous resectionLocal recurrenceTumor characteristicsOverall survivalArtery embolizationPancreatic resectionPercutaneous ablationBilobar distributionPostoperative deaths
2007
Predictive Molecular Markers for Colorectal Cancer Patients With Resected Liver Metastasis and Adjuvant Chemotherapy
Lassmann S, Tang L, Capanu M, Brabletz T, Schöpflin A, Hausen A, Gonen M, Kemeny N, Shia J, Klimstra D, Werner M. Predictive Molecular Markers for Colorectal Cancer Patients With Resected Liver Metastasis and Adjuvant Chemotherapy. Gastroenterology 2007, 133: 1831-1839. PMID: 18054556, DOI: 10.1053/j.gastro.2007.08.075.Peer-Reviewed Original ResearchConceptsResection of liver metastasesResectable liver metastasesHepatic arterial infusionLiver metastasesColorectal cancer patientsColorectal cancerHepatic recurrenceOverall survivalCyclin D1Arterial infusionQuantitative RT-PCR dataRT-PCR dataSurvivin messenger RNA levelsClinically relevant patient subgroupsAssociated with overall survivalLow cyclin D1Microdissected tumor cellsPredictive molecular markersRT-PCRRelevant patient subgroupsSurvivin messenger RNAReverse-transcription polymerase chain reactionMessenger RNA levelsExtrahepatic recurrenceSystemic irinotecan
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