Predictive Molecular Markers for Colorectal Cancer Patients With Resected Liver Metastasis and Adjuvant Chemotherapy
Lassmann S, Tang L, Capanu M, Brabletz T, Schöpflin A, Hausen A, Gonen M, Kemeny N, Shia J, Klimstra D, Werner M. Predictive Molecular Markers for Colorectal Cancer Patients With Resected Liver Metastasis and Adjuvant Chemotherapy. Gastroenterology 2007, 133: 1831-1839. PMID: 18054556, DOI: 10.1053/j.gastro.2007.08.075.Peer-Reviewed Original ResearchConceptsResection of liver metastasesResectable liver metastasesHepatic arterial infusionLiver metastasesColorectal cancer patientsColorectal cancerHepatic recurrenceOverall survivalCyclin D1Arterial infusionQuantitative RT-PCR dataRT-PCR dataSurvivin messenger RNA levelsClinically relevant patient subgroupsAssociated with overall survivalLow cyclin D1Microdissected tumor cellsPredictive molecular markersRT-PCRRelevant patient subgroupsSurvivin messenger RNAReverse-transcription polymerase chain reactionMessenger RNA levelsExtrahepatic recurrenceSystemic irinotecan
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