2025
Effects of Lung Expansion on Global and Regional Pulmonary Blood Volume in a Sheep Model of Acute Lung Injury
Zang M, Zeng C, Lagier D, Leng N, Grogg K, Motta-Ribeiro G, Laine A, Winkler T, Melo M. Effects of Lung Expansion on Global and Regional Pulmonary Blood Volume in a Sheep Model of Acute Lung Injury. Anesthesiology 2025, 142: 1071-1084. PMID: 39946655, PMCID: PMC12074886, DOI: 10.1097/aln.0000000000005412.Peer-Reviewed Original ResearchPositive end-expiratory pressurePulmonary blood volumeLung expansionBlood volumeLung injurySystemic endotoxemiaMechanical ventilationRespiratory-gated positron emission tomographyVentilator-induced lung injuryModel of acute lung injuryDistribution of blood volumeAcute lung injuryLow-volume mechanical ventilationLung injury modelEnd-expiratory pressureQuantify blood volumePulmonary capillary blood volumeLow blood volumeRegional blood volumePositron emission tomographyVascular blood volumeCapillary blood volumeLung blood volumeCapillary closureEnd-inspiration
2014
4D numerical observer for lesion detection in respiratory‐gated PET
Lorsakul A, Li Q, Trott C, Hoog C, Petibon Y, Ouyang J, Laine A, Fakhri G. 4D numerical observer for lesion detection in respiratory‐gated PET. Medical Physics 2014, 41: 102504. PMID: 25281979, PMCID: PMC4281099, DOI: 10.1118/1.4895975.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsComputer SimulationFluorodeoxyglucose F18HumansImage Interpretation, Computer-AssistedLung DiseasesModels, BiologicalMonte Carlo MethodMotionPhantoms, ImagingPositron-Emission TomographyRadiopharmaceuticalsRegression AnalysisRespiratory-Gated Imaging TechniquesSignal-To-Noise RatioConceptsRespiratory-gated positron emission tomographyMotion-corrected imagesDetection signal-to-noise ratioLesion detection taskNumerical observationsLesion detection performanceSignal-to-noise ratioPositron emission tomography sinogramsSpherical lesionsHotelling observerMotion correction methodPositron emission tomographyGeant4 ApplicationTomographic EmissionChannelized Hotelling observerAnthropomorphic phantomScanner geometryOSEM algorithmMonte Carlo simulationsPET framesImprove lesion detectionLesion detectionSignal-to-noise ratio measurementsActivity distributionConventional 3D approach
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