1997
Role of DNA mismatch repair in the cytotoxicity of ionizing radiation.
Fritzell J, Narayanan L, Baker S, Bronner C, Andrew S, Prolla T, Bradley A, Jirik F, Liskay R, Glazer P. Role of DNA mismatch repair in the cytotoxicity of ionizing radiation. Cancer Research 1997, 57: 5143-7. PMID: 9371516.Peer-Reviewed Original ResearchConceptsMammalian cellsCellular responsesCell linesTranscription-coupled repairMMR systemWild-type cellsDNA-damaging agentsWild-type cell linesMMR-deficient cellsDNA mismatch repairDNA mismatch repair systemMismatch repair systemActive genesFutile repairMMR factorsAlkylation damageMismatch repairReplication errorsDNA damageRepair systemRelated miceCancer cellsClonogenic survivalMMR genesGenes
1995
Intragenic Domains of Strand-specific Repair inEscherichia coli
Kunala S, Brash D. Intragenic Domains of Strand-specific Repair inEscherichia coli. Journal Of Molecular Biology 1995, 246: 264-272. PMID: 7869378, DOI: 10.1006/jmbi.1994.0082.Peer-Reviewed Original ResearchConceptsTranscription-repair coupling factorTranscription start siteStart siteEscherichia coli genesUV-induced cyclobutane pyrimidine dimersStrand-specific repairMfd mutationExcision repair mechanismChromatin domainsIntragenic domainsGenomic organizationMfd geneColi geneCyclobutane pyrimidine dimersLacZ transcriptionDNA repairInEscherichia coliDownstream domainIndividual nucleotidesRepair mechanismsGenesTranscriptionRepair systemDNA strandsInduced levels
1994
A novel role for DNA photolyase: binding to DNA damaged by drugs is associated with enhanced cytotoxicity in Saccharomyces cerevisiae.
Fox M, Feldman B, Chu G. A novel role for DNA photolyase: binding to DNA damaged by drugs is associated with enhanced cytotoxicity in Saccharomyces cerevisiae. Molecular And Cellular Biology 1994, 14: 8071-8077. PMID: 7969145, PMCID: PMC359345, DOI: 10.1128/mcb.14.12.8071.Peer-Reviewed Original ResearchMeSH Keywords4-Nitroquinoline-1-oxideCisplatinDeoxyribodipyrimidine Photo-LyaseDNA DamageDNA, FungalDNA-Binding ProteinsDose-Response Relationship, DrugEndodeoxyribonucleasesFungal ProteinsMechlorethamineMethylnitronitrosoguanidinePyrimidine DimersSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsConceptsBinding to DNADNA photolyaseYeast Saccharomyces cerevisiaeGenes increased sensitivityAlkylating agent N-methyl-N'-nitro-N-nitrosoguanidineInterfere with cell survivalRepair cyclobutane pyrimidine dimersSaccharomyces cerevisiaeAssociated with resistanceCyclobutane pyrimidine dimersNucleotide excision repair systemN-methyl-N'-nitro-N-nitrosoguanidineExcision repair systemCell survivalDNAPhotolyasePyrimidine dimersAIDS survivalAnticancer drug cis-diamminedichloroplatinumRepair systemCis-DDPYeastMutantsNucleotideMutationsA Novel Role for DNA Photolyase: Binding to DNA Damaged by Drugs Is Associated with Enhanced Cytotoxicity in Saccharomyces cerevisiae
Fox M, Feldman B, Chu G. A Novel Role for DNA Photolyase: Binding to DNA Damaged by Drugs Is Associated with Enhanced Cytotoxicity in Saccharomyces cerevisiae. Molecular And Cellular Biology 1994, 14: 8071-8077. DOI: 10.1128/mcb.14.12.8071-8077.1994.Peer-Reviewed Original ResearchBinding to DNADNA photolyaseYeast Saccharomyces cerevisiaeGenes increased sensitivityAlkylating agent N-methyl-N'-nitro-N-nitrosoguanidineInterfere with cell survivalRepair cyclobutane pyrimidine dimersSaccharomyces cerevisiaeAssociated with resistanceCyclobutane pyrimidine dimersNucleotide excision repair systemN-methyl-N'-nitro-N-nitrosoguanidineExcision repair systemCell survivalDNAPhotolyaseNovel rolePyrimidine dimersAIDS survivalAnticancer drug cis-diamminedichloroplatinumRepair systemAssociated with enhanced cytotoxicityCis-DDPYeastMutants
1992
Excision repair at individual bases of the Escherichia coli lacI gene: relation to mutation hot spots and transcription coupling activity.
Kunala S, Brash DE. Excision repair at individual bases of the Escherichia coli lacI gene: relation to mutation hot spots and transcription coupling activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 11031-11035. PMID: 1438309, PMCID: PMC50477, DOI: 10.1073/pnas.89.22.11031.Peer-Reviewed Original ResearchConceptsTranscribed strandMutation hot spotsChromosomal DNAExcision repairIndividual nucleotidesEscherichia coli chromosomeExcision repair systemColi chromosomeMfd geneDistribution of mutationsGene fragmentsDNA fragmentsEnzymatic incisionCell extractsLacI geneUV-induced mutationsSite of labelingEscherichia coliRepair systemSpecific gene fragmentsUV photoproductsGenesBase variationsMutationsNucleotides
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