Definition of the Extended Substrate Specificity Determinants for β-Tryptases I and II*
Harris J, Niles A, Burdick K, Maffitt M, Backes B, Ellman J, Kuntz I, Haak-Frendscho M, Craik C. Definition of the Extended Substrate Specificity Determinants for β-Tryptases I and II*. Journal Of Biological Chemistry 2001, 276: 34941-34947. PMID: 11438529, DOI: 10.1074/jbc.m102997200.Peer-Reviewed Original ResearchConceptsExtended substrate specificitySubstrate specificitySubstrate specificity determinantsPreferred substrate sequenceBasic amino acidsSpecificity determinantsAdjacent protomersSubstrate librariesSubstrate sequenceGlu-217Thr-96Multiple substratesCleavage siteRelevant substratesAmino acidsPotent tryptase inhibitorExtended substrateStructural determinantsAsp-189Ground state substrateFunctional determinantsSpecificity dataTryptase inhibitorsBetaIMolecular docking
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