2015
Structure Diversification of Vancomycin through Peptide-Catalyzed, Site-Selective Lipidation: A Catalysis-Based Approach To Combat Glycopeptide-Resistant Pathogens
Yoganathan S, Miller SJ. Structure Diversification of Vancomycin through Peptide-Catalyzed, Site-Selective Lipidation: A Catalysis-Based Approach To Combat Glycopeptide-Resistant Pathogens. Journal Of Medicinal Chemistry 2015, 58: 2367-2377. PMID: 25671771, PMCID: PMC4364393, DOI: 10.1021/jm501872s.Peer-Reviewed Original ResearchConceptsStructure diversificationLipid chain lengthStructure-activity relationship studiesPeptide catalystsCatalytic approachAliphatic hydroxylDerivatization sitesDerivatives 9aGlycopeptide-resistant pathogensNovel antibiotic leadsChain lengthLipid chainsRelationship studiesAntibiotic leadsCatalystCatalysisAntibiotic-resistant infectionsHydroxylHereinScaffoldsBioactivityChainSpectraLipidationIncorporation
2010
Cytotoxic and antioxidant effects of methoxylated stilbene analogues on HepG2 hepatoma and Chang liver cells: Implications for structure activity relationship
Hasiah A, Ghazali A, Weber J, Velu S, Thomas N, Inayat Hussain S. Cytotoxic and antioxidant effects of methoxylated stilbene analogues on HepG2 hepatoma and Chang liver cells: Implications for structure activity relationship. Human & Experimental Toxicology 2010, 30: 138-144. PMID: 20385705, DOI: 10.1177/0960327110368739.Peer-Reviewed Original ResearchConceptsChang liver cellsHepG2 hepatomaTotal antioxidant activityLiver cellsCytotoxic effectsAntioxidant activityFerric Reducing Antioxidant Power AssayChemopreventive activityAntioxidant effectsAntioxidant power assayStilbene analoguesSelective antiproliferative agentsStructure-activity relationship studiesHepG2 cellsAntiproliferative agentsHighest antioxidant activityPower assayHepatomaActivity relationship studiesStructural activity relationshipCytotoxicCellsActivity relationshipsRelationship studiesStructure-activity relationships
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