2024
SARS-CoV-2-related bat viruses evade human intrinsic immunity but lack efficient transmission capacity
Peña-Hernández M, Alfajaro M, Filler R, Moriyama M, Keeler E, Ranglin Z, Kong Y, Mao T, Menasche B, Mankowski M, Zhao Z, Vogels C, Hahn A, Kalinich C, Zhang S, Huston N, Wan H, Araujo-Tavares R, Lindenbach B, Homer R, Pyle A, Martinez D, Grubaugh N, Israelow B, Iwasaki A, Wilen C. SARS-CoV-2-related bat viruses evade human intrinsic immunity but lack efficient transmission capacity. Nature Microbiology 2024, 9: 2038-2050. PMID: 39075235, DOI: 10.1038/s41564-024-01765-z.Peer-Reviewed Original ResearchBat coronavirusesRelatives of SARS-CoV-2Upper airwayUpper airways of miceEpithelial cellsHuman nasal epithelial cellsAirways of miceMajor histocompatibility complex class I.SARS-CoV-2Nasal epithelial cellsHistocompatibility complex class I.Human bronchial epithelial cellsGenetic similarityBronchial epithelial cellsInnate immune restrictionCoronavirus replicationFunctional characterizationMolecular cloningReduced pathogenesisImpaired replicationBat virusCoronavirus pathogenesisPandemic potentialHigh-risk familiesImmune restriction
2016
Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa
Chan BK, Sistrom M, Wertz JE, Kortright KE, Narayan D, Turner PE. Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa. Scientific Reports 2016, 6: 26717. PMID: 27225966, PMCID: PMC4880932, DOI: 10.1038/srep26717.Peer-Reviewed Original ResearchConceptsMDR P. aeruginosaMDR Pseudomonas aeruginosaEfflux pump mechanismAntibiotic-resistant infectionsResistant bacterial infectionsPseudomonas aeruginosaReceptor-binding siteMDR bacteriaTherapeutic interventionsResistant infectionsBacterial infectionsReduced pathogenesisAntibiotic sensitivityAntibiotic classesPhage therapyCurrent antibioticsNovel antibacterial strategiesTherapyP. aeruginosaInfectionBacterial pathogensBacterial resistanceLytic bacteriophagesAntibioticsTraditional antibiotics
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