Dendrimer-Based Responsive MRI Contrast Agents (G1–G4) for Biosensor Imaging of Redundant Deviation in Shifts (BIRDS)
Huang Y, Coman D, Hyder F, Ali MM. Dendrimer-Based Responsive MRI Contrast Agents (G1–G4) for Biosensor Imaging of Redundant Deviation in Shifts (BIRDS). Bioconjugate Chemistry 2015, 26: 2315-2323. PMID: 26497087, PMCID: PMC4784965, DOI: 10.1021/acs.bioconjchem.5b00568.Peer-Reviewed Original ResearchConceptsGn-PAMAMResponsive MRI contrast agentsNonexchangeable protonsRedundant deviationLigands/drugsChemical shift informationMRI contrast agentsMolecular imaging platformParamagnetic monomerModifiable surfaceBiocompatible macromoleculesContrast agentsDendrimersSurface modificationDrug deliveryModel dendrimersG2-PAMAMShift informationUnique propertiesTransverse relaxation timeTmDOTAFluorescent dyeMonomersMolecular imagingProminent signal