Hajime Kato, MD, PhD
Associate Research Scientist in PathologyCards
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Research
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2025
The prevalence of ENPP1 deficiency in humans with Ossification of the Posterior Longitudinal Ligament and the preclinical efficacy of ENPP1 enzyme therapy in murine Ossification of the Posterior Longitudinal Ligament
Srivastava S, Kato H, von Kroge S, Weise K, Stabach P, Lopez S, O’Brien K, Lester E, Kim H, Ishaq T, Dammen-Brower K, Schinke T, Kimura S, Miyahara J, Doi T, Oshima Y, Yarema K, Carpenter T, Sabbagh Y, Tommasini S, Ito N, Oheim R, Braddock D. The prevalence of ENPP1 deficiency in humans with Ossification of the Posterior Longitudinal Ligament and the preclinical efficacy of ENPP1 enzyme therapy in murine Ossification of the Posterior Longitudinal Ligament. Journal Of Bone And Mineral Research 2025, zjaf168. PMID: 41251406, PMCID: PMC13084927, DOI: 10.1093/jbmr/zjaf168.Peer-Reviewed Original ResearchDiffuse idiopathic skeletal hyperostosisENPP1 deficiencyPreclinical efficacyOPLL patientsPlasma levelsBone fragilitySpinal fracture riskMonoallelic pathogenic variantsCortical bone microarchitectureEnzyme replacement therapyPosterior longitudinal ligamentAlkaline phosphatase levelsIdiopathic skeletal hyperostosisLong bonesPathogenesis of OPLLPlasma PPiSpinal fracturesReplacement therapySurgical correctionFracture riskProspective studyPhosphate wastingLongitudinal ligamentBone microarchitecturePathogenic variantsPHEX Protein in the Parathyroid Gland Contributes to Phosphate Sensing
Irie K, Kato H, Adachi N, Kimura S, Hoshino Y, Hidaka N, Tanaka S, Nangaku M, Saito T, Makita N, Ito N. PHEX Protein in the Parathyroid Gland Contributes to Phosphate Sensing. The Journal Of Clinical Endocrinology & Metabolism 2025, 111: e1-e8. PMID: 40512822, DOI: 10.1210/clinem/dgaf357.Peer-Reviewed Original ResearchTumor-induced osteomalaciaX-linked hypophosphatemiaSerum Pi levelsIntact PTHParathyroid hormoneParathyroid glandsPi loadingFibroblast growth factorTumor-induced osteomalacia patientsPHEX proteinX-linked hypophosphatemia patientsOral phosphate administrationSerum cCa levelIntact parathyroid hormoneParathyroid hormone secretionLoss-of-function variantsPi levelsTertiary hyperparathyroidismPHEX geneSerum PiPhosphate administrationPatientsGrowth factorPHEXSerumAcquired Osteomalacia Associated with Autoantibodies against PHEX
Hoshino Y, Okamoto K, Ogawa T, Kato H, Irie K, Watanabe S, Kimura S, Hidaka N, Kinoshita Y, Kobayashi H, Hagiwara D, Kogawa M, Takayanagi H, Tanaka S, Nangaku M, Makita N, Burbelo P, Saito T, Ito N. Acquired Osteomalacia Associated with Autoantibodies against PHEX. The New England Journal Of Medicine 2025, 392: 513-515. PMID: 39879599, PMCID: PMC11781776, DOI: 10.1056/nejmc2405746.Commentaries, Editorials and LettersExcess fibroblast growth factor 23 in alcoholic osteomalacia is derived from the bone
Hidaka N, Oyama Y, Koga M, Kondo N, Yasunaga Y, Shimakura T, Yamamoto N, Takahashi H, Iwafuchi Y, Watanabe S, Kimura S, Hoshino Y, Kato H, Kinoshita Y, Kobayashi H, Tanaka T, Ushiku T, Nangaku M, Tanaka S, Makita N, Saito T, Ito N. Excess fibroblast growth factor 23 in alcoholic osteomalacia is derived from the bone. JBMR Plus 2025, 9: ziaf010. PMID: 39963340, PMCID: PMC11831984, DOI: 10.1093/jbmrpl/ziaf010.Peer-Reviewed Original ResearchFGF23-related hypophosphatemic osteomalaciaPhosphor-integrated dotsHypophosphatemic osteomalaciaFGF23-related hypophosphatemiaSecretion of FGF23Differential diagnosisFGF23 expressionExcessive fibroblast growth factor 23Cessation of alcohol consumptionFGF23 expression levelsTumor-induced osteomalaciaFibroblast growth factor 23Rare conditionSensitive immunohistochemistryAlcoholic patientsPhosphaturic hormoneFibroblast growth factorOsteomalaciaExcess FGF23Conventional immunohistochemistryImmunohistochemistryFGF23Immunohistochemical approachReference levelGrowth factor
2024
Effect of Mutation Type on Ectopic Ossification Among Adult Patients With X-Linked Hypophosphatemia
Kato H, Ishihara Y, Ohata Y, Irie K, Watanabe S, Kimura S, Hoshino Y, Hidaka N, Kinoshita Y, Taniguchi Y, Kobayashi H, Braddock D, Kubota T, Ozono K, Nangaku M, Makita N, Ito N. Effect of Mutation Type on Ectopic Ossification Among Adult Patients With X-Linked Hypophosphatemia. Journal Of The Endocrine Society 2024, 8: bvae184. PMID: 39498416, PMCID: PMC11532897, DOI: 10.1210/jendso/bvae184.Peer-Reviewed Original ResearchX-linked hypophosphatemiaNonsense-mediated decayEctopic ossificationPathogenic variantsSpinal computed tomography scansMutation typeInhibitor of tissue calcificationComputed tomography scanSpinal ligament ossificationGenotype-phenotype correlationKellgren-Lawrence classificationNon-consanguineous familyPHEX mutationsPHEX variantAdult patientsTomography scanLigament ossificationFibroblast growth factorYellow ligamentOS indexKellgren-LawrenceStudy populationTissue calcificationPatientsProtein functionLatent metabolic bone disease, skeletal dysplasia and other conditions related to low bone formation among 38 patients with subtrochanteric femoral fractures: a retrospective observational study
Kimura S, Sunouchi T, Watanabe S, Hoshino Y, Hidaka N, Kato H, Takeda S, Nangaku M, Makita N, Azuma K, Kojima T, Matsubara T, Saito T, Ito N. Latent metabolic bone disease, skeletal dysplasia and other conditions related to low bone formation among 38 patients with subtrochanteric femoral fractures: a retrospective observational study. Osteoporosis International 2024, 35: 1633-1643. PMID: 38951164, PMCID: PMC11364693, DOI: 10.1007/s00198-024-07168-4.Peer-Reviewed Original ResearchConceptsAtypical femoral fracturesLow bone formationSubtrochanteric femoral fracturesMetabolic bone diseaseLoss-of-function variantsBone diseaseFemoral fracturesAntiresorptive agentsBone formationSerum alkaline phosphatase levelsSkeletal dysplasiaOral glucocorticoid useUniversity of Tokyo HospitalDepartment of Orthopedic SurgeryRetrospective observational studyAlkaline phosphatase levelsLong-term useHypophosphatemic osteomalaciaClinical fracturesGlucocorticoid useRecurrent fracturesJapanese patientsSpinal surgeryMethodsClinical informationOsteoporotic patientsCardiovascular Outcomes of KCNJ5 Mutated Aldosterone-Producing Adenoma: A Systematic Review
Kato H, Kitamoto T, Kimura S, Sunouchi T, Hoshino Y, Hidaka N, Tsurutani Y, Ito N, Makita N, Nishikawa T, Nangaku M, Inoue K. Cardiovascular Outcomes of KCNJ5 Mutated Aldosterone-Producing Adenoma: A Systematic Review. Endocrine Practice 2024, 30: 670-678. PMID: 38657793, DOI: 10.1016/j.eprac.2024.04.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAldosterone-producing adenomaRisk of biasCure of hypertensionKCNJ5 mutationsNon-randomized studiesSystematic reviewCardiovascular outcomesClinical featuresCardiac functionMetabolic outcomesPotential burdenSerious risk of biasSystematic review of observational studiesReview of observational studiesObservational studyNon-randomized Studies of InterventionsModerate riskModerate risk of biasImpaired cardiac functionStudies of interventionsUnfavorable cardiovascular outcomesQuality of evidenceKCNJ5 mutational statusPrimary aldosteronismMutation statusAcquired Forms of Fibroblast Growth Factor 23-Related Hypophosphatemic Osteomalacia
Ito N, Hidaka N, Kato H. Acquired Forms of Fibroblast Growth Factor 23-Related Hypophosphatemic Osteomalacia. Endocrinology And Metabolism 2024, 39: 255-261. PMID: 38467164, PMCID: PMC11066443, DOI: 10.3803/enm.2023.1908.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTumor-induced osteomalaciaDifferential diagnosisFibrous dysplasia/McCune-Albright syndromePositron Emission Tomography/Computed TomographyAutosomal dominant hypophosphatemic ricketsEmission Tomography/Computed TomographyCessation of drugFibroblast growth factor 23FGF23-producing tumorsSerum phosphate levelsAdequate differential diagnosisIdentification of FGF23Tomography/Computed TomographyTherapeutic optionsRegulation of serum phosphate levelVenous samplingHypophosphatemic ricketsInvasive proceduresHypophosphatemic rickets/osteomalaciaHumoral factorsSyndromeMedical costsPhosphate levelsOsteomalaciaPatientsExtended curettage for tumour-induced osteomalacia in the bone
Okajima K, Kobayashi H, Ito N, Kato H, Ishibashi Y, Zhang L, Tsuda Y, Tanaka S. Extended curettage for tumour-induced osteomalacia in the bone. Japanese Journal Of Clinical Oncology 2024, 54: 463-470. PMID: 38266040, DOI: 10.1093/jjco/hyad180.Peer-Reviewed Original ResearchConceptsTumor-induced osteomalaciaPostoperative biochemical remissionCausative tumorExtended curettageLumbar spineBiochemical remissionMedian follow-up durationComplex reconstructionFollow-up durationIntraoperative 3D fluoroscopyHigh-speed burringFunctional impairmentOncological outcomesRemission rateTumor resectionAdjuvant therapyConservative treatmentCurettageInvestigated patientsTumorBone tumorsElectric scalpelOsteomalaciaRemissionPatientsFGF-23, Left Ventricular Hypertrophy, and Mortality in Patients With CKD: A Revisit With Mediation Analysis
Hidaka, N, Inoue, K, Kato, H. et al. FGF-23, Left Ventricular Hypertrophy, and Mortality in Patients With CKD: A Revisit With Mediation Analysis. JACC Adv. 2024 Jan, 3 (1) . https://doi.org/10.1016/j.jacadv.2023.100747Peer-Reviewed Original Research
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