About
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Titles
Instructor
Biography
I am a physician-scientist track candidate in the Department of Pathology, with fellowship training in both cytopathology and molecular pathology. I am currently a post-doc in Don Nguyen's laboratory, studying how lung carcinoma metastasizes to the central nervous system.
Last Updated on October 02, 2023.
Appointments
Pathology
InstructorPrimary
Other Departments & Organizations
- Janeway Society
- Nguyen Lab
- Pathology
- Yale Medicine
- Yale New Haven Health System
Education & Training
- Fellow, Cytopathology
- Yale New Haven Hospital (2023)
- Fellow, Molecular Genetic Pathology
- Yale New Haven Hospital (2022)
- Chief Resident, Anatomic and Clinical Pathology
- Yale New Haven Hospital (2021)
- Resident, Anatomic and Clinical Pathology
- Yale New Haven Hospital (2020)
- PhD
- Upstate Medical University (2017)
- MD
- Upstate Medical University (2017)
- BS
- Cornell University (2006)
Research
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Overview
The goal of one ongoing research project, which is supported by an intradepartmental Chair’s Challenge grant, is to detect driver and resistance mutations in pleural fluid-derived circulating tumor DNA from patients with lung adenocarcinoma. The aim of this project is to use an error-suppressed multiplex deep sequencing platform, originally designed to detect low abundance tumor-specific mutations in plasma, to detect mutations with high sensitivity in the supernatants of malignant pleural effusions.
ORCID
0000-0002-4067-6481
Research at a Glance
Yale Co-Authors
Frequent collaborators of Darin Dolezal's published research.
Publications Timeline
A big-picture view of Darin Dolezal's research output by year.
Guoping Cai, MD, MS
Don Nguyen, PhD
Haiying Zhan, MD, PhD
MingDe Lin, PhD
Padmini Manrai, MD
Peter Podany, MD
5Publications
17Citations
Publications
2026
Matched MRI, Segmentations, and Histopathologic Images of Brain Metastases from Primary Lung Cancer
Chadha S, Sritharan D, Dolezal D, Chande S, Hager T, Bousabarah K, Aboian M, Chiang V, Lin M, Nguyen D, Aneja S. Matched MRI, Segmentations, and Histopathologic Images of Brain Metastases from Primary Lung Cancer. Scientific Data 2026, 13: 40. PMID: 41513658, PMCID: PMC12808229, DOI: 10.1038/s41597-025-06353-2.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsPrimary lung cancerBrain metastasesFluid-attenuated inversion recoveryLung cancer patientsLung cancerCancer patientsFLAIR hyperintensityImaging of brain metastasesManagement of lung cancer patientsContrast enhancementKaplan-Meier analysisCase of magnetic resonanceT1-weighted contrast-enhancedMetastasis biopsiesRetrospective studyMatched MRIFormalin-FixedMetastasisRadiomic featuresPatientsPrognostic modelClinical informationInversion recoveryMagnetic resonanceCancer
2025
Fine‐Needle Aspiration Biopsy of Adrenal Gland Lesions: The Roles of Image Guidance, Rapid On‐Site Evaluation and Additional Tissue Sampling
Yu S, Dolezal D, Aslanian H, Cai G. Fine‐Needle Aspiration Biopsy of Adrenal Gland Lesions: The Roles of Image Guidance, Rapid On‐Site Evaluation and Additional Tissue Sampling. Cytopathology 2025, 36: 228-235. PMID: 39878416, DOI: 10.1111/cyt.13472.Peer-Reviewed Original ResearchCitationsAltmetricConceptsFine-needle aspirationDiagnosis of adrenal lesionsCytological diagnostic categoriesAdrenal lesionsIndeterminate cytological diagnosisNon-diagnostic rateCytological diagnosisEndoscopic ultrasoundEUS-FNAOn-site evaluationNon-diagnosticImage guidanceComputed tomographyCT-guided fine-needle aspirationEvaluation of adrenal lesionsFine-needle aspiration diagnosisTissue samplesFine-needle aspiration proceduresLeft adrenal lesionRight adrenal lesionRapid on-site evaluationNon-ROSE groupIncrease diagnostic yieldImage guidance methodsCore tissue biopsiesComprehensive Molecular Profiling of Metastatic Pancreatic Adenocarcinomas
Antony V, Sun T, Dolezal D, Cai G. Comprehensive Molecular Profiling of Metastatic Pancreatic Adenocarcinomas. Cancers 2025, 17: 335. PMID: 39941707, PMCID: PMC11815932, DOI: 10.3390/cancers17030335.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMetastatic pancreatic ductal adenocarcinomaPancreatic ductal adenocarcinomaPrimary pancreatic ductal adenocarcinomaMolecular profilingGene mutationsGene copy number alterationsAdvanced-stage pancreatic cancerInsufficient tumor cellsOncomine Comprehensive AssayRate of TP53Copy number alterationsMetastatic diseasePDAC casesPIK3CA mutationsPancreatic cancerPoor prognosisTreatment optionsDuctal adenocarcinomaTumor cellsTumor progressionMolecular alterationsStudy cohortMolecular testingComprehensive assayTherapeutic target
2024
The World Health Organization Reporting System for Lung Cytopathology–A Review of the First Edition
Dolezal D, Kholová I, Cai G. The World Health Organization Reporting System for Lung Cytopathology–A Review of the First Edition. Journal Of Clinical And Translational Pathology 2024, 4: 18-35. PMID: 38736711, PMCID: PMC11086742, DOI: 10.14218/jctp.2023.00068.Peer-Reviewed Original ResearchCitationsConceptsClinical management recommendationsRisk of malignancyCytomorphologic criteriaLung cytopathologyImprove patient careAncillary testsEstimated risk of malignancyReporting systemDiagnostic categoriesPatient carePotential diagnostic pitfallsGroup of lesionsPractice settingsManagement recommendationsPractice recommendationsDiagnostic pitfallsEstimated riskCytopathology specimensCytopathology practiceLungCytopathologyLesionsMalignancyCytopathologistsSpecimen types
2023
Breast Carcinoma With Tubulopapillary Features Has a Distinct Immunophenotypic and Molecular Signature: A Report of Two Tumors and Literature Review
Carrasco-Tenezaca F, Moreira-Dinzey J, Manrai P, Bearse M, Burela S, Podany P, Singh K, Pareja F, Zheng J, Muscato N, Liang Y, Zhan H, Krishnamurti U, Dolezal D, Wang J, Harigopal M. Breast Carcinoma With Tubulopapillary Features Has a Distinct Immunophenotypic and Molecular Signature: A Report of Two Tumors and Literature Review. International Journal Of Surgical Pathology 2023, 32: 1037-1045. PMID: 37908113, DOI: 10.1177/10668969231209780.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsConceptsBreast carcinomaTubulopapillary featuresHuman epidermal growth factor 2 (HER2) expressionBreast cancer histologic subtypesNonmetastatic breast carcinomaTriple-negative profileHigh-grade nuclear featuresTriple-negative carcinomasHigh-grade featuresMetastatic breast carcinomaGrowth factor 2 expressionFactor 2 expressionReports of tumorsMicropapillary projectionsNeoadjuvant therapyHistologic subtypeWorse prognosisFirst tumorPoor prognosisAdditional tumorsInvasive carcinomaEstrogen receptorCarcinomaPathogenic variantsTumors
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