1997
Axotomy Increases the Excitability of Dorsal Root Ganglion Cells With Unmyelinated Axons
Zhang J, Donnelly D, Song X, Lamotte R. Axotomy Increases the Excitability of Dorsal Root Ganglion Cells With Unmyelinated Axons. Journal Of Neurophysiology 1997, 78: 2790-2794. PMID: 9356426, DOI: 10.1152/jn.1997.78.5.2790.Peer-Reviewed Original ResearchConceptsDorsal root gangliaUnmyelinated axonsRoot gangliaSodium currentTTX-sensitive sodium currentWhole-cell patch-clamp recordingsCell patch-clamp recordingsDorsal root ganglion cellsTTX-resistant currentC cellsEffects of axotomyAction potential thresholdPatch-clamp recordingsAction potential durationNeuropathic painVoltage-clamp conditionsPeak sodium currentDRG cellsGanglion cellsSoma sizeFast BlueNerve fibersConduction velocityAxotomyPotential duration
1991
Psychophysical Studies of the Itch Sensation and Itchy Skin (“Alloknesis”) Produced by Intracutaneous Injection of Histamine
Simone D, Alreja M, Lamotte R. Psychophysical Studies of the Itch Sensation and Itchy Skin (“Alloknesis”) Produced by Intracutaneous Injection of Histamine. Somatosensory & Motor Research 1991, 8: 271-279. PMID: 1767623, DOI: 10.3109/08990229109144750.Peer-Reviewed Original ResearchConceptsDuration of itchSubcutaneous injectionIntracutaneous injectionItchy skinArea of alloknesisSensation of itchMicrograms of histamineSkin temperatureItch sensationLocal anesthesiaAlloknesisMean latencyInjection siteMean maximum areaItchHuman volunteersHistamineVolar forearmDose-response functionInjectionNeural mechanismsSkinDoseDurationMicrograms
1984
Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and human
LaMotte R, Torebjörk H, Robinson C, Thalhammer J. Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and human. Journal Of Neurophysiology 1984, 51: 1434-1450. PMID: 6737035, DOI: 10.1152/jn.1984.51.6.1434.Peer-Reviewed Original ResearchConceptsNociceptive afferent fibersDevelopment of hyperalgesiaConditioning stimulusPain ratingsHeat stimulationAfferent fibersHairy skinHeat-evoked dischargesCervical spinal cordMagnitude of painMild heat injurySimilar response magnitudesMean frequencyPoststimulus time histogramsNociceptor activityCutaneous painResponse latencyHyperalgesic skinSpinal cordAwake humansC-fibersAnesthetized monkeysConduction velocityPainHeat stimuli