2011
In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans
Ma C, Nie H, Gu Q, Sikand P, LaMotte RH. In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans. Journal Of Neurophysiology 2011, 107: 357-363. PMID: 21994268, PMCID: PMC3349700, DOI: 10.1152/jn.00801.2011.Peer-Reviewed Original ResearchConceptsNociceptive sensationsCowhage spiculesC-nociceptorsNociceptive neuronsReceptive fieldsCutaneous receptive fieldsNoxious mechanical stimuliC-fibre rangePeripheral neural mechanismsExtracellular electrophysiological recordingsAxonal conduction velocityMean discharge rateChemical itchElicit itchChemical stimuliMechanosensitive nociceptorsConduction velocityMechanosensitive neuronsHeat stimuliItchCell bodiesElectrophysiological recordingsVivo responseCapsaicinHistamine
1993
Responses of cutaneous mechanoreceptors to the shape of objects applied to the primate fingerpad
LaMotte R, Srinivasan M. Responses of cutaneous mechanoreceptors to the shape of objects applied to the primate fingerpad. Acta Psychologica 1993, 84: 41-51. PMID: 8237455, DOI: 10.1016/0001-6918(93)90071-x.Peer-Reviewed Original Research
1992
Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.
LaMotte R, Lundberg L, Torebjörk H. Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. The Journal Of Physiology 1992, 448: 749-764. PMID: 1593488, PMCID: PMC1176226, DOI: 10.1113/jphysiol.1992.sp019068.Peer-Reviewed Original ResearchConceptsDuration of painMagnitude of painC-nociceptorsCapsaicin injectionMechanical hyperalgesiaIntradermal injectionTopical applicationReceptive fieldsC-mechanoheat nociceptorsEffects of capsaicinMean discharge rateCutaneous hyperalgesiaHyperalgesic areaUnchanged responsivenessBackground painAlgesic substancesPeroneal nerveNociceptor excitabilityNociceptor responsesPain thresholdMechanical stimuliNociceptor dischargeIntense painConcomitant painAwake humans
1991
Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia
Baumann T, Simone D, Shain C, LaMotte R. Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia. Journal Of Neurophysiology 1991, 66: 212-227. PMID: 1919668, DOI: 10.1152/jn.1991.66.1.212.Peer-Reviewed Original ResearchConceptsAfferent fibersNeurogenic hyperalgesiaPrimary hyperalgesiaNociceptive fibersPrimary afferentsIntradermal injectionHeat stimuliInjection siteReceptive fieldsCutaneous primary afferent fibersCapsaicin injection siteCutaneous afferent fibersNociceptive afferent fibersInjection of capsaicinCapsaicin-induced painPrimary afferent fibersPeripheral nervous systemPeripheral neural mechanismsArea of skinCapsaicin painSecondary hyperalgesiaDepressed responsivenessCapsaicin injectionIntense painHyperalgesia
1986
Tactile detection of a dot on a smooth surface: peripheral neural events
LaMotte R, Whitehouse J. Tactile detection of a dot on a smooth surface: peripheral neural events. Journal Of Neurophysiology 1986, 56: 1109-1128. PMID: 3097273, DOI: 10.1152/jn.1986.56.4.1109.Peer-Reviewed Original ResearchConceptsNumber of impulsesVon Frey filamentsPeripheral nerve fibersAnesthetized macaque monkeysReceptive fieldsFiber recordingsNerve fibersMacaque monkeysAction potentialsCertain stimulus conditionsNerve impulsesMagnitude of sensationTactile detectionSensory magnitudeStimulus conditionsResponse of RACapacity of humansSensory detectionNeural eventsMechanical eventsMonkeysSame stimuliSkinSensationRA
1984
Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C-fibers
Torebjörk H, LaMotte R, Robinson C. Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C-fibers. Journal Of Neurophysiology 1984, 51: 325-339. PMID: 6707724, DOI: 10.1152/jn.1984.51.2.325.Peer-Reviewed Original ResearchConceptsConditioning stimulusIntensity-response functionsNormal skinMost subjectsC-mechanoheat nociceptorsPeripheral neural correlateHeat pain sensationMild heat injuryMagnitude ratingsReceptive fieldsHeat injurySupra-threshold stimuliShort-duration stimuliPain thresholdCutaneous painHeat painPain sensationC-fibersPainNociceptorsHairy skinUninjured skinHeat stimulationMagnitude of responseNeuronal correlates
1982
Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat
LaMotte R, Thalhammer J, Torebjörk H, Robinson C. Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat. Journal Of Neuroscience 1982, 2: 765-781. PMID: 7086482, PMCID: PMC6564351, DOI: 10.1523/jneurosci.02-06-00765.1982.Peer-Reviewed Original ResearchConceptsConditioning stimulusCutaneous hyperalgesiaMild injuryDevelopment of hyperalgesiaHeat injuryMagnitude of hyperalgesiaMild heat injurySingle conditioning stimulusMagnitude of sensitizationPeripheral neural mechanismsReceptive fieldsPeroneal nervePeripheral determinantsCutaneous receptorsC-fibersAwake humansConduction blockAnesthetized monkeysHyperalgesiaNociceptorsPainGlabrous skinNormal skinInjuryHeat stimulationSpatial properties of nociceptor sensitization following heat injury of the skin
Thalhammer J, LaMotte R. Spatial properties of nociceptor sensitization following heat injury of the skin. Brain Research 1982, 231: 257-265. PMID: 7055680, DOI: 10.1016/0006-8993(82)90364-x.Peer-Reviewed Original Research
1981
Heat sensitization of one‐half of a nociceptor's receptive field does not alter the sensitivity of the other half
Thalhammer J, LaMotte R. Heat sensitization of one‐half of a nociceptor's receptive field does not alter the sensitivity of the other half. Pain 1981, 11: s42. DOI: 10.1016/0304-3959(81)90255-4.Peer-Reviewed Original Research
1979
Intensive and Temporal Determinants of Thermal Pain
LaMotte R. Intensive and Temporal Determinants of Thermal Pain. 1979, 327-361. DOI: 10.1007/978-1-4613-3039-4_18.Peer-Reviewed Original ResearchMagnitude of painNociceptive afferentsNoxious stimulationNeural activityPeripheral afferent nerve fibersAfferent nerve fibersHeat-sensitive nociceptorsPain sensationPeripheral nervesConscious humansNerve fibersPainThermal painDistal endingsAfferentsNeural determinantsThreat of injuryStimulus temperatureNociceptorsStimulationInjuryReceptive fieldsSkinTemporal determinantsPsychophysical studies