Martin A Schwartz PhD

Robert W. Berliner Professor of Medicine (Cardiology) and Professor of Biomedical Engineering and of Cell Biology

Research Interests

Integrin signaling; Mechanotransduction; Atherosclerosis; Vascular remodeling; Heart disease; Extracellular matrix; Cell adhesion; Cytoskeleton; Cell-cell junctions; Fluid shear stress

Selected Publications

  • Conway DE, Breckenridge MT, Hinde E, Gratton E, Chen CS, Schwartz MA. Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1. Curr Biol. 2013 Jun 3, 23:1024-30
  • Hoffman, B.D., Grashoff, C. and Schwartz, M.A. Dynamic molecular processes mediate cellular mechanotransduction. Nature. 2011, 475:316-323.
  • Grashoff C., Hoffman BD., Brenner MD., Zhou R., Parsons M., Yang MT., McLean MA., Sligar SG., Chen CS., Ha T. and Schwartz, MA.. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature, 2010,466:263-6.
  • Orr, A.W., Stockton, R., Simmers,M.B., Sanders, J.M., Sarembock, I.J., Blackman, B.R., Schwartz, M.A. Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis. J Cell Biol. 2007, 176:719-727.
  • Balasubramanian, N., Scott, D.W., Castle, J.D., Casanova, J.E., Schwartz, M.A. Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts. Nat Cell Biol. 2007, 9:1381-1391.
  • Tzima, E, Irani-Tehrani, M., Kiosses, W. B., Dejana, E., Schultz, D. A., Engelhardt, B., Cao, G., DeLisser, H., Schwartz, M. A. Identification of a mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature 2005, 437:426-430.

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