Henry Klar Yaggi MD, MPH

Associate Professor of Medicine (Pulmonary); Director, Yale Program in Sleep

Research Interests

Obstructive sleep apnea;stroke;cardiovascular disease;diabetes;clinical epidemiology;sleep-disordered breathing;clinical trials; prognosis;

Current Projects

Agency: VA Clinical Science Research and Develop I.D.# Merit Review Award Title: “Oxygen versus PAP for treatment of sleep apnea in chronic heart failure” P.I.: Yaggi/Gottlieb Role: Principal Investigator Percent effort: 35% Direct costs per year: $250,000 Total costs for project period: $1,500,000 Project period: 10/01/2012 – 09/30/2016

Agency: National institute of Health/National Institute of Nursing Research I.D.# 1P20NR014126-01 Title Yale Center for Sleep Disturbance in Acute and Chronic Conditions P.I. Henry Klar Yaggi, M.D. M.P.H. Percent Effort: 12.5% Direct costs per year: $250,000 Total costs for project period: $1,250,000 Project period: 10/01/2012-9/30/2017

Agency: NIH National Heart Lung and Blood institute (NHLBI) I.D.# U34 HL105285-01 Title: “Sleep Apnea in TIA/ Stroke: Reducing Vascular Risk with CPAP (SLEEP TIGHT)” P.I.: Henry Klar Yaggi, M.D. M.P.H. Percent effort: 30% Direct costs per year: $500,000 Total costs for project period: $2,000,000 Project period: 10/01/2010 – 06/31/2014

Agency: NIH National Heart Lung and Blood institute (NHLBI) I.D.# R21 MD006769 Title: “Multi-Level Modeling of Social Disparities in Sleep and Health” P.I.: Andre Araujo, Ph.D Role: Co-investigator Percent effort: 5% Direct costs per year: $250,000 Total costs for project period: $500,000 Project period: 10/01/2011 – 09/30/2014


Research Summary

Dr. Yaggi is an Associate Professor of Medicine at the Yale University School of Medicine and Director of the Yale Program in Sleep Medicine. He is board certified in Internal Medicine, Pulmonary Medicine, Critical Care, and Sleep Medicine. He is a Principal Investigator at the national VA Clinical Epidemiology Research Center. His research interest is the clinical epidemiology of sleep-disordered breathing, with a focus on the diverse health implications of sleep apnea and an emphasis on informing clinical care. Within this larger domain, his work has focused on 3 specific topics: sleep apnea as a risk factor for adverse cardiovascular and metabolic health outcomes; prognostic factors for adverse cardiovascular and metabolic health outcomes in patients with sleep-disordered breathing; and the impact of diagnosing and treating sleep apnea (using home-based strategies) on cardiovascular risk.

Extensive Research Description

Principal Investigator at the national VA Clinical Epidemiology Research Center. His research interest is the clinical epidemiology of sleep-disordered breathing, with a focus on the diverse health implications of sleep apnea and an emphasis on informing clinical care. Within this larger domain, his work has focused on 3 specific topics: sleep apnea as a risk factor for adverse cardiovascular and metabolic health outcomes; prognostic factors for adverse cardiovascular and metabolic health outcomes in patients with sleep-disordered breathing; and the impact of diagnosing and treating sleep apnea (using home-based strategies) on cardiovascular risk.


Selected Publications

  • Bravata D, Concato J, Fried T, Ranjbar N, Sadarangani T, McClain V, Struve F, Zygmunt L, Lo A, Richerson G, Gorman M, Williams L, Brass L, Agostini J, Mohsenin V, Roux F, Yaggi H. Auto-titrating continuous positive airway pressure for patients with acute stroke: a randomized feasibility trial. Sleep 2011, In Press.
  • Yaggi H, Botros N, Shaw N, Bravata D, Mohsenin V, Concato J. A clinical prognostic system for cardiovascular events and death in sleep-disordered breathing.Sleep and Breathing. 2011, In Press.
  • Fragoso C, Concato J, Macavay G, Van Ness P, Rochester C, Yaggi H, Gill T. Evaluating Respiratory Impairment in Middle-Aged Persons Using Lamda MU-Sigma Derived Z-scores. Respir Care. 2011;104:1189-96.
  • Fragoso C, Concato J, Macavay G, Van Ness P, Rochester C, Yaggi H, Gill T. The ratio of FEV1 to FVC as a basis for establishing chronic obstructive pulmonary disease. Am J Resp Crit Care Med. 2010,181: 446-51
  • Botros N, Concato J, Mohsenin V, Doctor K, Selim B, Yaggi H. Obstructive sleep apnea as a risk factor for type 2 diabetes. Am J Med. 2009, 122:1122-7.
  • Mohsenin V, Yaggi H, Shah N, Dziuri J The effect of gender on the development of hypertension in obstructive sleep apnea. Sleep Med. 2009, 10:759-762.
  • Yaggi H, Araujo A, McKinley J. Sleep Duration as Risk Factor for Type 2 Diabetes Mellitus: Diabetes Care 2006 29(3):657-61.
  • Yaggi H, Concato J, Kernan W, Lichtman J, Brass L, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. New England Journal of Medicine. 2005 353 (19): 2035-2041.
  • Yaggi H, Mohsenin V. Obstructive sleep apnea and stroke. Lancet Neurol. 20043(6):333-42.

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