Basmah Safdar MD, FACEP

Assistant Professor of Emergency Medicine; Co-Chair, Chest Pain Center

Research Interests

Clinical research; Chest pain center; Women and cardiovascular disease; Sex- and gender-specific research; Cardiac biomakers; Coronary risk factors; Depression; Disparities; Education; Chest pain in a multidimensional model; Pain; Perception; Women's health; Microvessel disease; Endothelial reactivity; persistent chest pain; systems costs.


Research Summary

Dr. Safdar's research interests include women’s health, in particular sex and gender disparities in cardiovascular health and a multisystem approach to pain management in the Emergency Department. Dr. Safdar has served as the Medical Director of the Yale New Haven Hospital Women’s Heart Program, a comprehensive community awareness program that aims to improve knowledge of women about heart disease (2008-2013). Dr. Safdar is also the Director of the Chest Pain Center.

Dr. Safdar's current research focuses on the physiology of microvascular disease and the role of persistent, unexplained chest pain as it affects patient-centered outcomes and systems costs. Dr. Safdar has won several research awards including Yale EM Research of the year award in 2004, Connecticut Chapter of Emergency Physicians (CCEP) award in 2004 and the National Best Clinical Science Research Award (Resident) by Society of Academic Emergency Medicine (SAEM) in 2005. Dr. Safdar speaks regularly at regional and national forums and has given several media presentations raising awareness about gender-specific forms of heart disease. She is currently the principal investigator for the RAMP-ED trial (RAnolazine for Microvascular angina by PET – in the Emergency Department). She also collaborates with VIRGO (Variation In Recovery: Role of Gender on Outcomes of Young AMI Patients), OPALS (Ontario Prehospital Advanced Life Support Study) and the Women’s Veterans Health Strategic Healthcare Group (cardiovascular) on studying sex/gender-specific outcomes.

For the past three years, Dr. Safdar has been leading a national collaborative initiative on Gender-Specific Research in Emergency Care. This multidisciplinary and multi-institutional effort is aimed to set the agenda for sex- and gender-specific research in emergency care research for the next five years.


Selected Publications

  • Safdar B, Bezek SK, Sinusas AJ, Russell RR, Klein MR, Dziura JD, D'onofrio G. (2014) Elevated CK-MB with a Normal Troponin Does Not Predict 30-Day Adverse Cardiac Events in Emergency Department Chest Pain Observation Unit Patients. Crit Pathw Cardiol. Mar;13(1):14-9.
  • Diercks DB, Mumma BE, Peacock FW, Hollander JE, Safdar B, Mahler SA, Miller CD, Nagurney JT. (2013) Incremental value of objective cardiac testing in addition to physician impression and serial contemporary troponin measurements in women. Academic Emergency Medicine. Mar;20(3):265-70.
  • McGregor A, Greenberg M, Safdar B, Pozananski S, Davenport M, Miner J, Choo E. (2013) Focusing a Gender Lens on Emergency Medicine Research – 2012 Update. Academic Emergency Medicine. Mar;20(3):313-20.
  • Diercks D, Peacock WF, Hollander J, Singer A, Birkhah R, Shapiro N, Glynn T, Nowack R, Safdar B, Miller C, Lewandrowski E, Nagurney J. (2012) Diagnostic accuracy of a point-of-care troponin I assay for acute myocardial infarction within 3 hours after presentation in early presenters to the emergency department with chest pain. American Heart Journal. Jan; 163(1):74-80.e4
  • Safdar B, Lichtman JH, D'Onofrio G (2012). Sex and the CT: An Evolving Story of the Heart. Acad Emerg Med. 2012 Feb;19(2):197-200.
  • Safdar B, McGregor AJ, McKee SA, Ali A, Radulescu R, Himelfarb NT, Klein MR, Mazure CM (2011). Inclusion of gender in emergency medicine research. Academic Emergency Medicine. Feb;18(2):e1-4.
  • Peacock WF, Diercks D, Hollander J, Singer A, Birkhah R, Shapiro N, Glynn T, Nowack R, Safdar B, Miller C, Bewandrowski E, Nagurney J (on behalf of the MIDAS Investigators) (2011). Myeloperoxidase in the Diagnosis of Acute Coronary Syndromes: The Importance of Spectrum. Am Heart J. Nov;162(5):893-9.
  • Safdar B, Foody JM, D’Onofrio G. (2010). Depression as Modifiable Coronary Risk factor in the Emergency Department Chest Pain Observation Unit. Critical Care Pathways in Cardiology. Volume 9, Number 2, June 2010.
  • Heins A, Homel P, Safdar B, Todd K.(2010). Physician Race/Ethnicity Predicts Successful Emergency Department Analgesia. Journal of Pain, 2010 Apr 9.
  • Safdar B, DeSandre P, Heins A, et al.(2009) Impact of Physician and Patient Gender on Pain Management in the Emergency Department – A Multi-Center study. Pain Medicine. Mar 2009; 10(2):364-72.

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