Cardiovascular Diseases; Chest Pain; Depression; Emergency Medicine; Women's Health; Health Care Quality, Access, and Evaluation; Healthcare Disparities
Dr. Safdar's research interests include women’s health, in particular sex and gender disparities in cardiovascular health and a multisystem approach to pain management in the Emergency Department. Dr. Safdar has served as the Medical Director of the Yale New Haven Hospital Women’s Heart Program, a comprehensive community awareness program that aims to improve knowledge of women about heart disease (2008-2013). Dr. Safdar is also the Director of the Chest Pain Center.
Dr. Safdar's current research focuses on the physiology of microvascular disease and the role of persistent, unexplained chest pain as it affects patient-centered outcomes and systems costs and resource utilization. Dr. Safdar has won several research awards including Yale EM Research of the year award in 2004, Connecticut Chapter of Emergency Physicians (CCEP) award in 2004 and the National Best Clinical Science Research Award (Resident) by Society of Academic Emergency Medicine (SAEM) in 2005. Dr. Safdar speaks regularly at regional and national forums and has given several media presentations raising awareness about gender-specific forms of heart disease. She is currently the principal investigator for the RAMP-ED trial (RAnolazine for Microvascular angina by PET – in the Emergency Department). She also collaborates with VIRGO (Variation In Recovery: Role of Gender on Outcomes of Young AMI Patients), OPALS (Ontario Prehospital Advanced Life Support Study) and the Women’s Veterans Health Strategic Healthcare Group (cardiovascular) on studying sex/gender-specific outcomes.
For the past three years, Dr. Safdar has been leading a national collaborative initiative on Gender-Specific Research in Emergency Care. This multidisciplinary and multi-institutional effort is aimed to set the agenda for sex- and gender-specific research in emergency care research for the next five years. Dr. Safdar was appointed President-Elect of Academy for Women in Academic Emergency Medicine (AWAEM).
Specialized Terms: Sex- and gender-specific research; Persistent chest pain physiology and patient-centered outcomes; Endothelial reactivity; Microvascular disease; Cardiac biomarkers; Coronary risk factors; Depression; Disparities; Chest pain in a multidimensional model.
- D'Onofrio G, Safdar B, Lichtman JH, Strait KM, Dreyer RP, Geda M, Spertus JA, Krumholz HM. (2015) Sex Differences in Reperfusion in Young Patients With ST-Segment-Elevation Myocardial Infarction: Results From the VIRGO Study. Circulation. Apr 14;131(15):1324-32.
- Safdar B, Nagurney JT, Anise A, DeVon H, D’Onofrio G, Hess EP, Hollander JE, Legato M, McGregor A, Scott J, Tewelde S, Diercks D (2014). Gender-Specific Research for Emergency Diagnosis and Management of Ischemic Heart Disease - Proceedings from the 2014 AEM Consensus Conference Cardiovascular Research Workgroup. Academic Emergency Medicine. Dec;21(12):1350-60.
- Safdar B, Stolz U, Stiell IG, Cone DC, Bobrow BJ, deBoehr M, Dreyer J, Maloney J, Spaite DW (2014). Differential Survival for Men and Women from Out-of-hospital Cardiac Arrest Varies by Age: Results from the OPALS Study. Academic Emergency Medicine. Dec;21(12):1503-1511.
- Safdar B, Greenberg MR (2014). Organization, Execution and Evaluation of the 2014 Academic Emergency Medicine Consensus Conference on Gender-Specific Research in Emergency Care – An Executive Summary. Academic Emergency Medicine; Dec;21(12):1307-17.
- Safdar B, Greenberg MR, Anise A, Brown J, Conwit R, Filart R, Scott J, Choo EK (2014). Funding Mechanisms for Gender-specific Research: Proceedings from a Panel Discussion at the 2014 Academic Emergency Medicine Consensus Conference. Acad Emerg Med. Dec;21(12):1329-33.
- Safdar B, Bezek SK, Sinusas AJ, Russell RR, Klein MR, Dziura JD, D'onofrio G. (2014) Elevated CK-MB with a Normal Troponin Does Not Predict 30-Day Adverse Cardiac Events in Emergency Department Chest Pain Observation Unit Patients. Crit Pathw Cardiol. Mar;13(1):14-9.
- Diercks DB, Mumma BE, Peacock FW, Hollander JE, Safdar B, Mahler SA, Miller CD, Nagurney JT. (2013) Incremental value of objective cardiac testing in addition to physician impression and serial contemporary troponin measurements in women. Academic Emergency Medicine. Mar;20(3):265-70.
- McGregor A, Greenberg M, Safdar B, Pozananski S, Davenport M, Miner J, Choo E. (2013) Focusing a Gender Lens on Emergency Medicine Research – 2012 Update. Academic Emergency Medicine. Mar;20(3):313-20.
- Diercks D, Peacock WF, Hollander J, Singer A, Birkhah R, Shapiro N, Glynn T, Nowack R, Safdar B, Miller C, Lewandrowski E, Nagurney J. (2012) Diagnostic accuracy of a point-of-care troponin I assay for acute myocardial infarction within 3 hours after presentation in early presenters to the emergency department with chest pain. American Heart Journal. Jan; 163(1):74-80.e4
- Safdar B, Lichtman JH, D'Onofrio G (2012). Sex and the CT: An Evolving Story of the Heart. Acad Emerg Med. 2012 Feb;19(2):197-200.
- Safdar B, McGregor AJ, McKee SA, Ali A, Radulescu R, Himelfarb NT, Klein MR, Mazure CM (2011). Inclusion of gender in emergency medicine research. Academic Emergency Medicine. Feb;18(2):e1-4.
- Peacock WF, Diercks D, Hollander J, Singer A, Birkhah R, Shapiro N, Glynn T, Nowack R, Safdar B, Miller C, Bewandrowski E, Nagurney J (on behalf of the MIDAS Investigators) (2011). Myeloperoxidase in the Diagnosis of Acute Coronary Syndromes: The Importance of Spectrum. Am Heart J. Nov;162(5):893-9.
- Safdar B, Foody JM, D’Onofrio G. (2010). Depression as Modifiable Coronary Risk factor in the Emergency Department Chest Pain Observation Unit. Critical Care Pathways in Cardiology. Volume 9, Number 2, June 2010.
- Heins A, Homel P, Safdar B, Todd K.(2010). Physician Race/Ethnicity Predicts Successful Emergency Department Analgesia. Journal of Pain, 2010 Apr 9.
- Safdar B, DeSandre P, Heins A, et al.(2009) Impact of Physician and Patient Gender on Pain Management in the Emergency Department – A Multi-Center study. Pain Medicine. Mar 2009; 10(2):364-72.
- Rao VS, Safdar B, Lee V (2008) Improvements in Time to Reperfusion: Women Have an Advantage. Critical Pathways in Cardiology
- Safdar B, Degutis L, Landry K et al. (2006). Prospective Randomized Controlled Trial comparing Efficacy and Adverse events of Intravenous Ketorolac and Parenteral morphine alone and in combination in the treatment of acute renal colic. Annals of Emergency Medicine. 2006; 48(2):173-181.