Arthur L Horwich, MD
Sterling Professor of Genetics and Professor of Pediatrics; and Investigator HHMI
Departments & Organizations
Genetics | Biological and Biomedical Sciences (BBS): Biochemistry, Biophysics and Structural Biology; Biochemistry, Biophysics and Structural Biology: crystallography, NMR, mass spectrometry, cryo-electron...faculty; Biochemistry, Biophysics and Structural Biology: Protein Folding, Dynamics and Degradation; Molecular Cell Biology, Genetics and Development | Pediatrics | Program in Cellular Neuroscience, Neurodegeneration and Repair: Affiliated Faculty
Research Interests
Chaperones in protein folding; ALS (Lou Gehrig's Disease)more...
Education
- M.D., Brown University, 1975
Selected Publications
- Elad, N., Farr, G.W., Clare, D.K., Orolova, E.V., Horwich, A.L., and Saibil, H.R. (2007). Topologies of a substrate protein bound to the chaperonin GroEL. Mol. Cell 26, 415-426.
- Apetri, A.C. and Horwich, A.L. (2008) Chaperonin chamber accelerates protein folding through passive action of preventing aggregation. Proc. Natl. Acad. Sci. USA 105, 17351-17355.
- Wang, J., Farr, G.W., Zeiss, C.J., Rodriguez-Gil, D.J., Wilson, J.H., Furtak, K., Rutkowski, D.T., Kaufman, R.J., Ruse, C.I., Yates, J.R. III, Perrin, S., Feany, M.B., and Horwich, A.L. (2009) Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice with ALS. Proc. Natl. Acad. Sci. USA 106, 1392-1397.
