Steven Schiff, MD, PhD, FACS
Harvey and Kate Cushing Professor of Neurosurgery, Vice Chair for Global Health, Department of Neurosurgery, Professor of Epidemiology, Department of Epidemiology of Microbial DiseasesCards
Appointments
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
Affiliated Faculty, Yale Program for Biomedical Ethics
Affiliated Faculty, Yale Interdepartmental Program in Neuroscience
Member, Yale Center for Brain and Mind Health
Contact Info
Neurosurgery
333 Cedar Street, TMP 413
New Haven, Connecticut 06510
United States
Appointments
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
Affiliated Faculty, Yale Program for Biomedical Ethics
Affiliated Faculty, Yale Interdepartmental Program in Neuroscience
Member, Yale Center for Brain and Mind Health
Contact Info
Neurosurgery
333 Cedar Street, TMP 413
New Haven, Connecticut 06510
United States
Appointments
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
Affiliated Faculty, Yale Program for Biomedical Ethics
Affiliated Faculty, Yale Interdepartmental Program in Neuroscience
Member, Yale Center for Brain and Mind Health
Contact Info
Neurosurgery
333 Cedar Street, TMP 413
New Haven, Connecticut 06510
United States
About
Titles
Harvey and Kate Cushing Professor of Neurosurgery, Vice Chair for Global Health, Department of Neurosurgery, Professor of Epidemiology, Department of Epidemiology of Microbial Diseases
Affiliated Faculty, Yale Institute for Global Health; Affiliated Faculty, Yale Program for Biomedical Ethics; Affiliated Faculty, Yale Interdepartmental Program in Neuroscience; Member, Yale Center for Brain and Mind Health
Biography
Dr. Steven Schiff is a pediatric neurosurgeon with interests in neural control engineering, sustainable health engineering and global health. He founded the Center for Neural Engineering at Penn State University, wrote the first book on Neural Control Engineering (MIT Press, 2012), and is now developing the Center for Global Neurosurgery at Yale University. He received the NIH Director’s Pioneer and Transformative Awards in 2015 and 2018, respectively, which have enabled him to pursue his interests in the sustainable control of infant infections in the developing world. This work has evolved into an exploration of what Schiff calls Predictive Personalized Public Health (P3H), and included leading the discovery of a new highly lethal infant brain disease in Africa - Neonatal Paenibacilliosis.
Appointments
Neurosurgery
ProfessorPrimaryEpidemiology of Microbial Diseases
ProfessorSecondary
Other Departments & Organizations
Education & Training
- Pediatric Neurosurgery Fellowship
- Children's Hospital of Philadelphia (1990)
- Neurosurgery Residency
- Duke University (1989)
- PhD
- Duke University, Physiology (1985)
- General Surgery Internship
- Duke University (1981)
- MD
- Duke University (1980)
Research
Overview
Medical Subject Headings (MeSH)
ORCID
0000-0003-2623-3614
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Andrew J Whalen
Joseph N Paulson, PhD
Mercedeh Javanbakht Movassagh
Ronald Mulondo
Adam de Havenon, MD, MSCI
Kevin Sheth, MD
Bacteria
Neonatal Sepsis
Brain Diseases
Africa South of the Sahara
Coinfection
Publications
2024
Engineering Principles and Bioengineering in Global Health
Harper J, Schiff S. Engineering Principles and Bioengineering in Global Health. Neurosurgery Clinics Of North America 2024 DOI: 10.1016/j.nec.2024.05.010.Peer-Reviewed Original ResearchPaediatric hydrocephalus
Kahle K, Klinge P, Koschnitzky J, Kulkarni A, MacAulay N, Robinson S, Schiff S, Strahle J. Paediatric hydrocephalus. Nature Reviews Disease Primers 2024, 10: 35. PMID: 38755194, DOI: 10.1038/s41572-024-00519-9.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSymptoms of elevated intracranial pressureCerebrospinal fluidCentral nervous system infectionChoroid plexus cauterizationEndoscopic third ventriculostomyNervous system infectionNonsurgical treatment strategiesElevated intracranial pressureLong-term outcomesNeural tube defectsCSF-brain interfaceFetal hydrocephalusUtero treatmentAcquired hydrocephalusCSF secretionSurgical closureCSF shuntingHead circumferenceThird ventriculostomyCongenital hydrocephalusAssociated with blockageGene mutationsCerebral ventricleTreatment strategiesCSF pathwaysThe genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact
Hale A, Boudreau H, Devulapalli R, Duy P, Atchley T, Dewan M, Goolam M, Fieggen G, Spader H, Smith A, Blount J, Johnston J, Rocque B, Rozzelle C, Chong Z, Strahle J, Schiff S, Kahle K. The genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact. Fluids And Barriers Of The CNS 2024, 21: 24. PMID: 38439105, PMCID: PMC10913327, DOI: 10.1186/s12987-024-00513-z.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCerebrospinal fluidOverview of genesEtiology of HCPathogenesis of HCChoroid plexus cauterizationEndoscopic third ventriculostomyIncreased intracranial pressureGenetic architectureGenetic basisImpact of geneticsVentricular shuntSurgical treatmentThird ventriculostomyPhenotypic heterogeneityHeterogeneous diseasePharmacological treatmentGenetic syndromesMolecular pathogenesisIntracranial pressureHydrocephalusTherapeutic measuresGenesGeneticsBrain injuryPathway
2023
Detection of Intracerebral Hemorrhage Using Low-Field, Portable Magnetic Resonance Imaging in Patients With Stroke
Mazurek M, Parasuram N, Peng T, Beekman R, Yadlapalli V, Sorby-Adams A, Lalwani D, Zabinska J, Gilmore E, Petersen N, Falcone G, Sujijantarat N, Matouk C, Payabvash S, Sze G, Schiff S, Iglesias J, Rosen M, de Havenon A, Kimberly W, Sheth K. Detection of Intracerebral Hemorrhage Using Low-Field, Portable Magnetic Resonance Imaging in Patients With Stroke. Stroke 2023, 54: 2832-2841. PMID: 37795593, PMCID: PMC11103256, DOI: 10.1161/strokeaha.123.043146.Peer-Reviewed Original ResearchCitationsAltmetricmbQTL: an R/Bioconductor package for microbial quantitative trait loci (QTL) estimation
Movassagh M, Schiff S, Paulson J. mbQTL: an R/Bioconductor package for microbial quantitative trait loci (QTL) estimation. Bioinformatics 2023, 39: btad565. PMID: 37707523, PMCID: PMC10516520, DOI: 10.1093/bioinformatics/btad565.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsSingle nucleotide variationsRNA sequencingMicrobial abundance dataQuantitative trait lociSingle nucleotide polymorphism dataRibosomal RNA sequencingField of genomicsWhole-genome sequencingEvidence of interplayMutational profileTrait lociMicrobial communitiesMicrobial abundancePolymorphism dataMicrobial populationsGenome sequencingAbundance dataFirst R packageHuman geneticsBioconductor packageGenetic variantsMicrobiome dataSequencingR packageAbundancePublisher Correction: Brain imaging with portable low-field MRI
Kimberly W, Sorby-Adams A, Webb A, Wu E, Beekman R, Bowry R, Schiff S, de Havenon A, Shen F, Sze G, Schaefer P, Iglesias J, Rosen M, Sheth K. Publisher Correction: Brain imaging with portable low-field MRI. Nature Reviews Bioengineering 2023, 1: 680-680. DOI: 10.1038/s44222-023-00100-1.Peer-Reviewed Original ResearchAltmetricBrain imaging with portable low-field MRI
Kimberly W, Sorby-Adams A, Webb A, Wu E, Beekman R, Bowry R, Schiff S, de Havenon A, Shen F, Sze G, Schaefer P, Iglesias J, Rosen M, Sheth K. Brain imaging with portable low-field MRI. Nature Reviews Bioengineering 2023, 1: 617-630. PMID: 37705717, PMCID: PMC10497072, DOI: 10.1038/s44222-023-00086-w.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSparse k-space dataK-space dataImage reconstructionUseful diagnostic imagesReconstruction algorithmLow power requirementsNew applicationsLF-MRIDiagnostic imagesNew approachNew opportunitiesHardwareConventional systemMachineOngoing developmentPower requirementsAlgorithmImagesTechnological innovationFurther innovationNoise cancellationNoise ratioTechnologyRequirementsInformationPaenibacillus spp infection among infants with postinfectious hydrocephalus in Uganda: an observational case-control study
Morton S, Hehnly C, Burgoine K, Ssentongo P, Ericson J, Kumar M, Hagmann C, Fronterre C, Smith J, Movassagh M, Streck N, Bebell L, Bazira J, Kumbakumba E, Bajunirwe F, Mulondo R, Mbabazi-Kabachelor E, Nsubuga B, Natukwatsa D, Nalule E, Magombe J, Erickson T, Ngonzi J, Ochora M, Olupot-Olupot P, Onen J, Ssenyonga P, Mugamba J, Warf B, Kulkarni A, Lane J, Whalen A, Zhang L, Sheldon K, Meier F, Kiwanuka J, Broach J, Paulson J, Schiff S. Paenibacillus spp infection among infants with postinfectious hydrocephalus in Uganda: an observational case-control study. The Lancet Microbe 2023, 4: e601-e611. PMID: 37348522, PMCID: PMC10529524, DOI: 10.1016/s2666-5247(23)00106-4.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMother-newborn pairsPostinfectious hydrocephalusCerebrospinal fluidNeonatal sepsisSpp infectionUgandan infantsMaternal bloodObservational case-control studyHospital OfficeInfant's cerebrospinal fluidBurden of morbidityCase-control studyRoute of infectionSubset of participantsMaternal feverCranial ultrasoundNeonatal infectionSepsis cohortOptimise treatmentTransplacental transmissionCord bloodObservational studyPlacental samplesSepsisHydrocephalusPortable MRI to assess optic chiasm decompression after endoscopic endonasal resection of sellar and suprasellar lesions.
Hong C, Lamsam L, Yadlapalli V, Parasuram N, Mazurek M, Chavva I, Lalwani D, Zabinska J, Schiff S, Manes R, Vining E, Rimmer R, Kimberly W, Sheth K, Omay S. Portable MRI to assess optic chiasm decompression after endoscopic endonasal resection of sellar and suprasellar lesions. Journal Of Neurosurgery 2023, 139: 1664-1670. PMID: 37347618, DOI: 10.3171/2023.5.jns23174.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEndoscopic endonasal surgeryOptic nerve decompressionEndonasal surgerySuprasellar lesionsNerve decompressionOptic chiasmThird ventricleConventional MRIOptic chiasm compressionEndoscopic endonasal resectionChiasm compressionPreoperative imagingSingle institutionEndonasal resectionMRI availabilityRoutine MRISignificant interrater reliabilitySuprasellar pathologiesSurgeryNeurosurgical oncologyLinear mixed-effects modelsPortable MRIPatientsMRIMixed-effects modelsNeonatal Paenibacilliosis: Paenibacillus Infection as a Novel Cause of Sepsis in Term Neonates With High Risk of Sequelae in Uganda
Ericson J, Burgoine K, Kumbakumba E, Ochora M, Hehnly C, Bajunirwe F, Bazira J, Fronterre C, Hagmann C, Kulkarni A, Kumar M, Magombe J, Mbabazi-Kabachelor E, Morton S, Movassagh M, Mugamba J, Mulondo R, Natukwatsa D, Kaaya B, Olupot-Olupot P, Onen J, Sheldon K, Smith J, Ssentongo P, Ssenyonga P, Warf B, Wegoye E, Zhang L, Kiwanuka J, Paulson J, Broach J, Schiff S. Neonatal Paenibacilliosis: Paenibacillus Infection as a Novel Cause of Sepsis in Term Neonates With High Risk of Sequelae in Uganda. Clinical Infectious Diseases 2023, 77: 768-775. PMID: 37279589, PMCID: PMC10495130, DOI: 10.1093/cid/ciad337.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNeonatal sepsisPostinfectious hydrocephalusCerebrospinal fluidSigns of sepsisFull-term neonatesOptimal antibiotic treatmentUgandan referral hospitalQuantitative polymerase chain reactionNeonatal characteristicsClinical sepsisTerm neonatesUnderdiagnosed causeAntibiotic choiceMedian ageReferral hospitalUgandan hospitalNeurodevelopmental impairmentAdverse outcomesSpecimen typesAntibiotic treatmentPolymerase chain reactionClinical signsUnusual pathogensSepsisHigh risk
Academic Achievements and Community Involvement
activity Journal of Computational Neuroscience
Journal ServiceEditorial Board MemberDetailsAction Editor07/01/2006 - Presentactivity Journal of Neural Engineering
Journal ServiceEditorial Board MemberDetails07/01/2013 - Presentactivity Neural Computation
Journal ServiceEditorial Board MemberDetailsAssociate Editor07/01/2015 - Presentactivity US Food and Drug Administration
Public ServiceScientific CommitteeDetailsNeurological Devices Panel, Medical Devices Advisory Committee07/28/2013 - Presentactivity Scientific Advisory Board
Advisory BoardsMemberDetailsInstitut de Neurosciences des Systèmes, Marseilles, France2019 - Present
Links & Media
News
- July 05, 2024Source: Yale News
Steven Schiff Named Harvey and Kate Cushing Professor of Neurosurgery
- November 01, 2023
From the journals
- September 08, 2023Source: This Week in Microbiology
This Week in Microbiology
- September 04, 2023Source: The Telegraph
The mysterious culprit behind ‘water on the brain’ in Ugandan babies
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Contacts
Neurosurgery
333 Cedar Street, TMP 413
New Haven, Connecticut 06510
United States