Deniz Bagdas, DVM, PhD
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Research Scientist in Psychiatry
Biography
Deniz Bagdas, DVM, PhD, is a research scientist in the Department of Psychiatry at Yale School of Medicine.
After Dr. Bagdas received her DVM, she earned her PhD in Pharmacology and Toxicology. During her PhD and post-doctoral career, she has had an extensive training in behavioral neuroscience and neuropharmacology. Her interests are focused on the role of neuronal nicotinic acetylcholine receptors in addiction as well as pain and inflammation. Currently, she has been investigating comorbidity of chronic pain and nicotine addiction. Her research also includes the impact of flavors on nicotine intake with a focus on behaviors related to nicotine addiction in both adult and adolescence.
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Psychiatry
Research ScientistPrimary
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Education & Training
- Postdoctoral Associate
- Virginia Commonwealth University, School of Medicine (2018)
- PhD
- Uludag University (2008)
- DVM
- Uludag University (2002)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Deniz Bagdas's published research.
Publications Timeline
A big-picture view of Deniz Bagdas's research output by year.
Asti Jackson, PhD
Nii Addy, PhD
Eric Nunes, PhD
Marina Picciotto, PhD
77Publications
1,717Citations
Publications
2024
Impact of vanilla flavor on nicotine taste, choice, intake, and seeking behaviors
Bagdas D, Zepei A, Harris L, Minanov K, Jimenez J, Addy N. Impact of vanilla flavor on nicotine taste, choice, intake, and seeking behaviors. Psychopharmacology 2024, 1-13. PMID: 38839631, DOI: 10.1007/s00213-024-06630-9.Peer-Reviewed Original ResearchConceptsTaste reactivity testNicotine choiceNicotine takingTwo-bottle free choice testSeeking behaviorOral nicotine intakeNicotine preferenceFree-choice testNicotine intakeIngestive responsesOral nicotineDecreased dislikeAversive responsesOral cuesYoung adult Sprague Dawley ratsOrosensory propertiesAdult Sprague Dawley ratsIncreased likingNicotineFemale ratsMale ratsSprague Dawley ratsTobacco productsLong-term effectsDawley ratsPhosphosulindac (OXT-328) prevents and reverses chemotherapy induced peripheral neuropathy in mice
Basu A, Yang J, Tsirukis V, Loiacono A, Koch G, Khwaja I, Krishnamurthy M, Fazio N, White E, Jha A, Shah S, Takmil C, Bagdas D, Demirer A, Master A, Natke E, Honkanen R, Huang L, Rigas B. Phosphosulindac (OXT-328) prevents and reverses chemotherapy induced peripheral neuropathy in mice. Frontiers In Neuroscience 2024, 17: 1240372. PMID: 38347876, PMCID: PMC10860339, DOI: 10.3389/fnins.2023.1240372.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyAnticancer effect of paclitaxelEffects of paclitaxelAllodynia scoresCold allodyniaPeripheral neuropathyInduces chemotherapy-induced peripheral neuropathyChemotherapeutic efficacy of paclitaxelLewis lung carcinoma xenograftsPrevent chemotherapy-induced peripheral neuropathyHind paw of miceAnticancer effectsTreat chemotherapy-induced peripheral neuropathyVon Frey testLevels of IL-6Chemotherapy induced peripheral neuropathyEfficacy of paclitaxelPaw of miceLung cancer xenograftsLung carcinoma xenograftsMale C57BL/6 J miceCell linesSide effects of chemotherapyEffects of chemotherapyApparent side effects
2022
Chronic oral nicotine exposure decreases aversive taste of nicotine, increases nicotine withdrawal and reinstatement, but cherry flavor does not alter nicotine’s effects in adolescent rats
Bagdas D, Harris L, Addy N. Chronic oral nicotine exposure decreases aversive taste of nicotine, increases nicotine withdrawal and reinstatement, but cherry flavor does not alter nicotine’s effects in adolescent rats. Neuroscience Letters 2022, 793: 137008. PMID: 36476758, PMCID: PMC9948648, DOI: 10.1016/j.neulet.2022.137008.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsTaste responsesNicotine concentrationsNicotine exposureNicotine withdrawalNicotine effectsAdolescent ratsChronic exposureOral nicotine exposureTaste reactivityAversive tasteChronic nicotine exposureDevelopment of toleranceLow nicotine concentrationsE-cigarette useE-cigarette flavoringsHigher nicotine concentrationsNicotine abstinenceNicotine useNaïve animalsChronic effectsNicotineRatsAversive responsesDifferent nicotine concentrationsWithdrawalPharmacological characterization of 5-iodo-A-85380, a β2-selective nicotinic receptor agonist, in mice
Akinola LS, Bagdas D, Alkhlaif Y, Jackson A, Gurdap CO, Rahimpour E, Carroll FI, Papke RL, Damaj MI. Pharmacological characterization of 5-iodo-A-85380, a β2-selective nicotinic receptor agonist, in mice. Journal Of Psychopharmacology 2022, 36: 1280-1293. PMID: 36321267, PMCID: PMC9817006, DOI: 10.1177/02698811221132214.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsNicotinic receptor agonistsReceptor agonistNicotinic acetylcholine receptorsLow sensitivityPharmacological characterizationΑ4β2 receptorsNicotine dependenceNicotinic subunitsPlace preferenceΑ4β2 nAChRsAcetylcholine receptorsPartial agonistFull agonistAgonistsDifferential efficacyBehavioral effectsNeurodegenerative diseasesSubtypesPathological conditionsNAChRsPotential targetPotential roleHypothermiaReceptorsΑ6Persistent sensory changes and sex differences in transgenic mice conditionally expressing HIV-1 Tat regulatory protein
Toma W, Paris J, Warncke U, Nass S, Caillaud M, McKiver B, Ondo O, Bagdas D, Bigbee J, Knapp P, Hauser K, Damaj M. Persistent sensory changes and sex differences in transgenic mice conditionally expressing HIV-1 Tat regulatory protein. Experimental Neurology 2022, 358: 114226. PMID: 36096180, PMCID: PMC10053560, DOI: 10.1016/j.expneurol.2022.114226.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSensory neuropathyFemale miceHIV-1Tat expressionSensory nerve action potentialsIntraepidermal nerve fiber densityChronic HIV-1Persistent sensory changesPain-like behaviorsPeripheral sensory neuropathySevere chronic painDevelopment of neuropathyNerve fiber densityLumbar spinal cordDevelopment of hypersensitivityNerve action potentialsPrevious preclinical studiesDorsal root gangliaTNF-α expressionPPAR-α gene expressionTat regulatory proteinRole of TatHIV-1 TatSex differencesAllodynic responsesGenotypic Differences in the Effects of Menthol on Nicotine Intake and Preference in Mice
Akinola LS, Rahman Y, Ondo O, Gonzales J, Bagdas D, Jackson A, Davidson-Wert N, Damaj MI. Genotypic Differences in the Effects of Menthol on Nicotine Intake and Preference in Mice. Frontiers In Neuroscience 2022, 16: 905330. PMID: 35769694, PMCID: PMC9234577, DOI: 10.3389/fnins.2022.905330.Peer-Reviewed Original ResearchCitationsAltmetricConceptsOral nicotine consumptionEffect of mentholD2J miceMenthol effectsNicotine consumptionΑ7 nAChRsDifferential effectsTwo-bottle choiceTAAR1 geneOral aversionC57BL/6J miceNicotine rewardSystemic administrationNicotine intakeDBA/2J miceB6J micePharmacological responseNicotine addictionGenotype-specific mechanismsNicotine concentrationsMiceMouse strainsBasal preferenceGenetic factorsNicotineCholinergic and dopaminergic‐mediated motivated behavior in healthy states and in substance use and mood disorders
Nunes EJ, Kebede N, Bagdas D, Addy NA. Cholinergic and dopaminergic‐mediated motivated behavior in healthy states and in substance use and mood disorders. Journal Of The Experimental Analysis Of Behavior 2022, 117: 404-419. PMID: 35286712, PMCID: PMC9743782, DOI: 10.1002/jeab.747.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMood disordersSubstance useActivational componentsMotivated behaviorComorbid substance useMesolimbic dopamine systemDA releaseCholinergic activityCholinergic transmissionImportant neuromodulatorCholinergic dysregulationDA regulationDopamine systemDA signalingActivational aspectsDisease statesDisordersAversive stimuliPossible roleHealthy stateCholinergicAcetylcholineStimuliEtiologyIllnessAnimal Models to Investigate the Impact of Flavors on Nicotine Addiction and Dependence
Bagdas D, Kebede N, Zepei AM, Harris L, Minanov K, Picciotto MR, Addy NA. Animal Models to Investigate the Impact of Flavors on Nicotine Addiction and Dependence. Current Neuropharmacology 2022, 20: 2175-2201. PMID: 35611777, PMCID: PMC9886843, DOI: 10.2174/1570159x20666220524120231.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsMeSH Keywords and Concepts
2021
Evaluation of Flavor Effects on Oral Nicotine Liking and/or Disliking Using the Taste Reactivity Test in Rats
Bagdas D, Rupprecht LE, Nunes EJ, Schillinger E, Immanuel JJ, Addy NA. Evaluation of Flavor Effects on Oral Nicotine Liking and/or Disliking Using the Taste Reactivity Test in Rats. Nicotine & Tobacco Research 2021, 24: 753-760. PMID: 34918123, PMCID: PMC8962681, DOI: 10.1093/ntr/ntab241.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsTaste reactivity testOrosensory experienceAversive responsesAbuse liabilityAversive valueAversive reactionsHedonic responsesNicotine rewardTaking behaviorIntraoral cathetersImpact of mentholReactivity testOlfactory cuesOrofacial movementsDislikingLikingNicotine responseTaste stimuliSex-dependent mannerOral nicotineNicotine inducesNicotineCuesIngestive responsesExperience(E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation
Bagdas D, Sevdar G, Gul Z, Younis R, Cavun S, Tae HS, Ortells MO, Arias HR, Gurun MS. (E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation. Neurological Research 2021, 43: 1056-1068. PMID: 34281483, DOI: 10.1080/01616412.2021.1949684.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPositive allosteric modulationΑ7 nAChRsNeuropathic painΑ7-selective antagonist methyllycaconitineΑ7 nicotinic acetylcholine receptorChronic constriction injuryPaw licking behaviorNeuropathic pain modelAcute systemic administrationChronic painful conditionsAntidepressant-like activityAnti-nociceptive activityDepression-like behaviorAnxiogenic-like effectsNicotinic acetylcholine receptorsAffective behaviorHuman α7 nAChRConstriction injuryMechanical allodyniaFormalin testPain modelAntagonist methyllycaconitineChronic painPainful conditionsRat α7 nAChR
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