A Randomized Phase II Study De-Intensified ChemoRadiation for Early-Stage Anal Squamous Cell Carcinoma (DECREASE)
Volunteers
Health Professionals
What is the purpose of this trial?
This phase II trial studies how well lower-dose chemotherapy plus radiation (chemoradiation) therapy works in comparison to standard-dose chemoradiation in treating patients with early-stage anal cancer. Drugs used in chemotherapy, such as mitomycin, fluorouracil, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving chemotherapy with radiation therapy may kill more tumor cells. This study may help doctors find out if lower-dose chemoradiation is as effective and has fewer side effects than standard-dose chemoradiation, which is the usual approach for treatment of this cancer type.
Help Us Discover!
You can help our team find trials you might be eligible for by creating a volunteer profile in MyChart. To get started, create a volunteer profile, or contact helpusdiscover@yale.edu, or call 877.978.8343 for more information.
Principal Investigator
Sub-Investigators
- Allison Campbell, MD, PhD
- Armand Russo, MD
- Beverly Drucker, MD, PhD
- Bruce A. McGibbon, MD
- Clarice Grens
- D. Barry Boyd, MD, MS
- Emily Kopas, APRN, OCN
- Henry S. Park, MD, MPH
- Jacquelyne Gaddy, MD, MSc, MSCR
- James Laird, MD
- Jeremy Kortmansky, MD
- Jill Lacy, MD
- Justin Persico, MD
- Katelyn Scott
- Kimberly L. Johung, MD, PhD
- Kristen Hoxie
- Larisa Fleysher
- Laura Van Metre Baum, MD, MPH
- M. Sung Lee, MD
- Matthew Austin, MD
- Michael Cecchini, MD
- Michael Cohenuram, MD
- Neal Fischbach, MD
- Pamela L. Kunz, MD
- Rebecca Vanasse-Passas, MD
- Renee Moye
- Robert Legare, MD
- Sara Anastasio, RN
- Stacey Stein, MD
- Susan Gueble, MD, PhD
- Teresa White
- Thomas Hayman, MD, PhD
- Vanna Dest
- Virginia Syombathy
- Yifei Zhang, MD
- Last Updated07/17/2024
- Study HIC#2000037486