Behavioral disorders in kids with autism linked to reduced brain connectivity
More than a quarter of children with autism spectrum disorder are also diagnosed with disruptive behavior disorders. For the first time, Yale researchers have identified a possible biological cause: a key mechanism that regulates emotion functions differently in the brains of the children who exhibit disruptive behavior.
In the Developing Brain, Scientists Find Roots of Neuropsychiatric Diseases
The most comprehensive genomic analysis of the human brain ever undertaken has revealed new insights into the changes it undergoes through development, how it varies among individuals, and the roots of neuropsychiatric illnesses such as autism spectrum disorders and schizophrenia.
Yale Child Study Center to Partner with Scholastic on New Literacy Research
The Yale Child Study Center and Scholastic have launched a new joint research endeavor: the Yale Child Study Center–Scholastic Collaborative for Child & Family Resilience. The collaborative will focus on the intersection of literacy and health across a range of education content areas — i.e. early childhood, social emotional learning and teaching, equity and social justice, and family and community engagement — with the ultimate goal of improving academic and mental health outcomes for children and their families.
Child Abuse Expert John M. Leventhal, MD, Awarded Leffell Prize for Clinical Excellence
John M. Leventhal, MD, has received the 2018 David J. Leffell Prize for Clinical Excellence in recognition of his exceptional achievements and his dedication to working with abused, neglected and sexually abused children.
How do we lose memory? A STEP at a time, researchers say
In mice, rats, monkeys, and people, aging can take its toll on cognitive function. A new study by researchers at Yale and Université de Montréal reveal there is a common denominator to the decline in all of these species — an increase in the level of the molecule striatal-enriched phosphatase, or STEP.
Lifespan Research: Impact of Childhood Disease on Adult Health
YCCI’s renewed CTSA grant award allows Yale to continue its leadership in cutting-edge areas of research. One such novel initiative under the grant renewal is Diseases Across the Lifespan, which will explore the rising field of lifespan research — a new approach to examining the ways in which diseases that commonly strike adults have their roots in infancy and early childhood.
Yale launches five-year study of origins of autism
Yale researchers will study the development of functional brain connectivity during late pregnancy to early adolescence thanks to a five-year, $12.4 million grant from Autism Centers of Excellence Program, part of efforts by the National Institutes of Health to understand the origins of autism spectrum disorders (ASD).
Lab-created mini-brains reveal how growing organ maintains neuronal balance
Scientists can now explore in a laboratory dish how the human brain develops by creating organoids — distinct, three-dimensional regions of the brain. In research published in Cell Stem Cell, Yale scientists coaxed early stage stem cells to create and fuse two types of organoids from different brain regions to show how the developing brain maintains proper balance of excitatory and inhibitory neurons.
Research Note: Irritability and ADHD medications
Irritability is common across psychiatric diagnoses, but is especially common in children with ADHD. Some common ADHD medications are purported to increase irritability, leading doctors and families to avoid them, even though medication is a highly effective treatment.
Acupuncture, Widely Used, Found to be Ineffective in Improving Live Birth Rate
In a surprising finding, a collaboration between the researchers in China, the United States and Europe reveals that acupuncture is ineffective in improving live birth rate in women with Polycystic Ovarian Syndrome, or PCOS, contrary to prevailing wisdom and common practice.
Tourette-like tics vanish in mice treated with histamine
Yale scientists produced increased grooming behavior in mice that may model tics in Tourette syndrome and discovered these behaviors vanish when histamine — a neurotransmitter most commonly associated with allergies — is introduced into their brains. Christopher Pittenger, MD, PhD, Associate Professor of Psychiatry, was the study's senior author.