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Diabetes, Obesity, and Weight Management Studies Enrolling at Yale

March 01, 2024
by Lisa Brophy

Be Part of Clinical Research at Yale

Does your 12- to 22-year-old have obesity or is at risk for developing obesity?

Our research team in Pediatric Endocrinology at Yale is studying what causes fatty liver disease and how sugars are playing a role on liver fat content in children and adolescents with obesity. We would like to understand why some kids develop fatty liver and others do not. Nonalcoholic fatty liver disease (NAFLD) is the leading cause of liver disease in pediatrics with an estimate of about 7 million children and adolescents affected in the US. Early onset fatty liver can mean many years of disease, predisposing youth to develop complications early in life.

We are looking for teenagers and young adults between the ages of 12-22, obese (BMI>30), and identify as Hispanic and/or Black/African American. Hispanic youth show the highest prevalence of NAFLD (~45%) compared to Non-Hispanic Blacks (NHB) (~13%). Understanding the mechanisms leading to the different susceptibility of ethnic groups to accumulate intrahepatic fat will provide important insights in the pathophysiology of fatty liver in kids. We are looking to include the group with the highest rate of fatty liver, Hispanic youths, and a group with the lowest rate Black/African American to gain a better understanding of fatty liver disease.

Participants will be asked to do 3 separate research study visits and follow up visits every 6 months after the research study visits.

Participants may be compensated up to $1370.

To learn more or to see if your child is eligible, please contact Kim Kunze, RN at (203) 785-4513 or email Kim.Kunze@Yale.edu.

Sponsored by the National Institute of Minority Health and Health Disparities (NIMHD); HIC# 200028731


Concerned about eating or overeating?

If you are between 21 and 50 years old with binge-eating disorder, you may be eligible for a brain-imaging study. Study visits involve in-person screening visits to determine eligibility, a 30-minute MRI scan, and a 90-minute PET scan. This is not a treatment study.

Compensation up to $400.

If you are interested in participating, or if you have any questions, please contact our study coordinators, Adam Stryjewski (adam.stryjewski@yale.edu; 203-535-4424) or Marcella Mignosa (marcella.mignosa@yale.edu; 203-903-7795) and mention “binge-eating study.”

Sponsored by National Institute of Mental Health (NIMH); HIC#2000034271


Do you have early stage Type 2 Diabetes?

If you are an individual with early-stage Type 2 Diabetes, with an HbA1C over 6.5%, are between the ages of 18-80, and are not on any injectable diabetes medicine, you may be eligible to participate in a free and confidential study that is being conducted at the Yale Diabetes Center to help learn more about the effects of ultrasound on lowering the body’s glucose (sugar) levels.

Compensation up to $500 for 4 study visits.

For more details:

Sponsored by National Institutes of Health (NIH); HIC#2000034954


Do you have Type 2 Diabetes?

Ultrasound Study for Diabetes

If you are an individual with Type 2 Diabetes, with an HbA1C 7.0-10.0%, are between the ages of 21-75, and are not on any injectable diabetes medicine, you may be eligible to participate in a free and confidential study that is being conducted by Dr. Raimund Herzog to help learn more about the effects ultrasound may have on lowering the body’s glucose (sugar) levels.

Compensation up to $500.

Read more on this exciting new research here.

For more details:

Sponsored by GE Global Research; HIC # 2000032493


Do you have diabetes?

Sight-saving Engagement and Evaluation in New Haven (SEEN) Program

If you are 18 years of age or older, have diabetes, and have not had an eye exam in the last year, you may be eligible to participate in SEEN Pilot study. Study participants will receive a full eye exam, be enrolled into a patient navigator program and will also be supplied with diabetic educational materials.

Compensation will be provided.

To learn more or see if you are eligible to participate, call (203) 361-4659 or email seen.program@yale.edu .

Sponsored by National Eye Institute; HIC# 2000031731


Concerns about your eating or weight after bariatric surgery?

If you are 18 to 70 years old and concerned about your weight or eating after bariatric surgery, you may be eligible to participate in a free and confidential treatment study.

Participants will receive up to $350 - $375 compensation.

To learn more or see if you are eligible to participate, please call the Yale Program for Obesity, Weight, and Eating Research at (203) 816-5623 or visit power.yale.edu

Sponsored by the National Institute of Diabetes and Digestive & Kidney Diseases (NIDDK); HIC # 2000029057


Adolescents with higher weight seeking treatment for bulimia nervosa

This study will test the feasibility and acceptability of two treatments for adolescents with higher weight seeking treatment for bulimia nervosa. Bulimia nervosa is when individuals binge eat (overeat while feeling like they lost control) and purge (do something extreme or unhealthy to lose weight or prevent weight gain). Bulimia nervosa happens across different ages and body sizes. This study is focusing on adolescents who have a larger body size (overweight or obesity, or recent substantial weight loss).

Adolescents will receive treatment that is 4 months of 45-minute sessions, weekly. Treatment will occur over telehealth (e.g., zoom), and the whole study is online.

To learn more please contact Yale Teen Power at 203-785-7821 or email: teenpower@yale.edu.

Sponsored by National Eating Disorders Association; Yale University School of Medicine; HIC# 2000033150

Submitted by Lena Smith Parker on January 24, 2024