Study to investigate adipocyte cell and lipid turnover in obese adolescents

What is the purpose of this trial?

The purpose of this study is to test whether the reduced transcription of key lipogenic/adipogenic genes in abdominal subcutaneous adipose tissue (SAT) in obese adolescents with a High VAT/SAT (visceral adipose tissue/subcutaneous adipose tissue) ratio translates functionally into a reduced in vivo triglyceride (TG) synthesis and adipocyte proliferation, which in turn will contribute to ectopic fat accumulation and insulin resistance (IR). To test whether the storage capacity of gluteal SAT is linked to the level of VAT/SAT fat distribution in obese adolescents. To explore if changes in dietary fat intake (palmitate intake), alters ceramide concentration in both plasma and adipose tissue (AT) and the Inflammasome complex in the different fat distribution phenotypes and their associations with IR.


Participation Guidelines

Ages: 12 - 21 years

Gender: Both


National Institute of Child Health and Human Development

Start Date: 07/22/2015

End Date: 05/01/2019

Last Updated: 02/22/2018

Study HIC#: 1503015459

Get Involved

For more information about this study, contact:
Jessica Nouws
+1 203-785-6972
jessica.nouws@yale.edu

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email helpusdiscover@yale.edu or call 1-877-978-8348.

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