Study to investigate adipocyte cell and lipid turnover in obese adolescents

Trial Purpose and Description

To test whether the reduced transcription of key lipogenic/adipogenic genes in abdominal subcutaneous adipose tissue (SAT) in obese adolescents with a High VAT/SAT (visceral adipose tissue/subcutaneous adipose tissue) ratio translates functionally into a reduced in vivo triglyceride (TG) synthesis and adipocyte proliferation, which in turn will contribute to ectopic fat accumulation and insulin resistance (IR). To test whether the storage capacity of gluteal SAT is linked to the level of VAT/SAT fat distribution in obese adolescents. To explore if changes in dietary fat intake (palmitate intake), alters ceramide concentration in both plasma and adipose tissue (AT) and the Inflammasome complex in the different fat distribution phenotypes and their associations with IR.

Ages: 12 - 21 years

Gender: Both


Eligibility Criteria

Inclusion Criteria:

  • Overweight (85-95th% age and gender specific) or Obese (>95th% age and gender specific)
  • Ages 12-18 years
  • Absence of any endocrinopathy
  • Absence of any therapy with medication known to alter glucose metabolism (i.e.: Oral steroids, certain psychiatric medications such as Xeleca, Lithium, Paxil)
  • English Speaking subjects

Exclusion Criteria:

  • Any disease known to alter glucose metabolism (T2DM)
  • Diuretic Medication
  • Pregnant or breastfeeding
  • Type 1 or 2 diabetes

National Institute of Child Health and Human Development

Start Date: 07/22/2015

End Date: 05/01/2019

Last Updated: 02/22/2018

Study HIC#: 1503015459

Get Involved

For more information about this study, contact:
Brittany Galuppo
+1 203-737-1547
brittany.galuppo@yale.edu

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email helpusdiscover@yale.edu or call 1-877-978-8348.

Trial Image

Investigators

Sonia Caprio

Principal Investigator

Sub-Investigators