What is the purpose of this trial?
Multicenter, prospective, phase 3 randomized non-blinded interventional trial of fluid treatment strategies in the first 24 hours for patients with sepsis-induced hypotension. The aim of the study is to determine the impact of a restrictive fluids strategy (vasopressors first followed by rescue fluids) as compared to a liberal fluid strategy (fluids first followed by rescue vasopressors) on 90-day in-hospital mortality in patients with sepsis-induced hypotension.
Ages: 18 years and older
National Heart, Lung, and Blood Institute
Start Date: 11/05/2018
End Date: 03/30/2021
Last Updated: 02/22/2019
Study HIC#: 2000023369