Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS)

What is the purpose of this trial?

Brief Summary:

Multicenter, prospective, phase 3 randomized non-blinded interventional trial of fluid treatment strategies in the first 24 hours for patients with sepsis-induced hypotension. The aim of the study is to determine the impact of a restrictive fluids strategy (vasopressors first followed by rescue fluids) as compared to a liberal fluid strategy (fluids first followed by rescue vasopressors) on 90-day in-hospital mortality in patients with sepsis-induced hypotension.

Participation Guidelines

Ages: 18 years and older

Gender: Both

National Heart, Lung, and Blood Institute

Start Date: 11/05/2018

End Date: 03/30/2021

Last Updated: 02/22/2019

Study HIC#: 2000023369

Get Involved

For more information about this study, contact:
Carolyn Brokowski
+1 860-874-6249

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email or call 1-877-978-8348.

Trial Image


Charles Wira

Principal Investigator