Behavioral and Neurochemical Mechanisms Underlying Stress-Precipitated Drinking

What is the purpose of this trial?

The primary goal of this project is to build upon our promising pilot data and conduct the first human laboratory study evaluating effect of stress on the ability to resist drinking and subsequent alcohol consumption in individuals with alcohol use disorders versus social drinking controls. Importantly, we will measure HPA-axis reactivity and subjective reactivity (e.g., craving) as mechanisms underlying stress-precipitated drinking. Results will: 1) Determine whether individuals with alcohol use disorders versus social drinking controls are more reactive to stress-precipitated drinking outcomes; 2) Provide important evidence that targeting brain stress systems and stress reactivity is a viable medication development strategy for alcohol use disorders; 3) Identify potential mechanisms underlying the effect of stress on alcohol use outcomes; and 4) Provide the data necessary to expand this investigation to a Phase II clinical trial. Taken together, the innovative components of this proposal will guide development of treatments targeting the HPA-axis system for alcohol use disorders.

Participation Guidelines

Ages: 21 - 55 years

Gender: Both

National Institute on Alcohol Abuse and Alcoholism

Start Date: 01/08/2019

End Date: 09/30/2022

Last Updated: 01/17/2019

Study HIC#: 2000021685

Get Involved

For more information about this study, contact:
Terril Verplaetse
+1 203-737-6496

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email or call 1-877-978-8348.

Trial Image


Terril Verplaetse

Principal Investigator