New Yale Center Will Focus on Infection and Immunity
The center will have an ambitious goal: to produce better diagnoses, treatments, and ultimately cures for an array of diseases. It will also work toward vaccine development, based on Iwasaki’s pioneering work showing that vaccines directed toward the mucosa might provide better protection than systemic vaccination.
Low mobility predicts hospital readmission in older heart attack patients
Close to 20% of elderly adults who have suffered a heart attack will be readmitted to the hospital within 30 days. Performance on a simple mobility test is the best predictor of whether an elderly heart attack patient will be readmitted, a Yale-led study reports.
You have two ages, chronological and biological. Here's why it matters
Essentially, everyone has two ages: a chronological age, how old the calendar says you are, and a phenotypic or biological age, basically the age at which your body functions as it compares to average fitness or health levels. Levine and her team identified nine biomarkers taken in a simple blood test that seemed to be the most influential on lifespan. The biomarkers include blood sugar, kidney and liver measures, and immune and inflammatory measures. Levine plugs those numbers into the computer, and the algorithm does the rest. People with a biological age lower than their chronological age have a lower mortality risk, while those aging older from a biological standpoint have a higher mortality risk and are potentially more prone to developing the diseases associated with the higher age range.Source: CNN
Vishwa Deep Dixit appointed the Von Zedtwitz Professor of Comparative Medicine
Vishwa Deep Dixit, newly named as the Waldemar Von Zedtwitz Professor of Comparative Medicine, studies the interaction between immune and metabolic systems with the goal of revealing targets that can be harnessed to extend the healthspan — the period of life that is free of disabilities and disease.
Yale center dedicated to research on older adults receives renewed funding
For the fifth consecutive time, the Yale Claude D. Pepper Older Americans Independence Center (OAIC) has been renewed for funding from the National Institute on Aging (NIA). The Center is one of only two such programs nationwide to receive continuous NIA support since it was first funded in 1992, marking more than 25 years of excellence in geriatrics and aging research under the leadership of Geriatrics Section Chief Dr. Mary Tinetti, Dr. Thomas Gill, and Dr. Terri Fried.
Dr. Gerald Shulman wins American Diabetes Association’s highest honor
Dr. Gerald I. Shulman of the Yale School of Medicine has won the 2018 Banting Medal for Scientific Achievement, the highest honor of the American Diabetes Association (ADA). Shulman will be recognized for this honor and deliver his Banting Medal Lecture, “Mechanisms of Insulin Resistance: Implications for Obesity, Lipodystrophy and Type 2 Diabetes,” at the ADA’s 78th Scientific Sessions in Orlando, Florida, June 22-26.
Happy 20th Anniversary, WHRY!
In recognition of Women's Health Research at Yale's 20th anniversary, the center’s many supporters, scientists, students, and mentees offered their thoughts and feelings about the last two decades and the change WHRY has made in leading us toward a healthier and happier future.
Study: Topical antibiotic triggers unexpected antiviral response
A Yale-led research team made a startling discovery while investigating the effect of bacteria on viral infections. When they applied a common topical antibiotic to mice before or shortly after infection with herpes and other viruses, they found that the antibiotic triggered an antiviral resistance in the animals, the researchers said.
A synthetic approach to helping the immune system thwart infections
Yale researchers have developed a set of synthetic molecules that may help boost the strength of a key, virus-fighting protein. The protein, RIG-I, is an important sensor in the immune system of humans and other animals. It recognizes and responds to viral RNA by surrounding it, latching onto it, and launching the immune system into action. The Yale team, led by biologists Anna Pyle and Akiko Iwasaki, has designed molecules that jump-start the process. These synthetic, stem-loop RNA (SLR) molecules can be visualized as short cords with a knot at one end. The configuration enables the SLRs to bind with RIG-I molecules in a way that prompts an aggressive response.
Yale Center for Biomedical Data Science is about ‘positive impact’
Big data is getting bigger. By 2025, genomics will have surpassed astronomy, Twitter, and YouTube to become the largest data-generating enterprise by far. What began 65 years ago when Watson, Crick, and Franklin unlocked the double helix of DNA has become, in just the past few years, an exponentially growing archive of individual genomes. Yale’s Center for Genome Analysis actually holds the ninth largest genomic library in the world.
Leptin hormone spurs body’s shift from burning carbs to fat
To keep the human brain supplied with energy when food was scarce, mammals evolved the ability to switch from burning carbohydrates to burning fat in order to preserve skeletal muscle that would otherwise be metabolized and converted to glucose. Scientists have long believed that the transition to fat metabolism was instigated solely by a drop in insulin. But a new study has identified leptin — a hormone made by fat cells — as a key mediator in this fundamental biological process.
Aging impairs innate immune response to flu
Aging impairs the immune system’s response to the flu virus in multiple ways, weakening resistance in older adults, according to a Yale study. The research reveals why older people are at increased risk of illness and death from flu, the researchers said.