Susan Compton, PhD
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Appointments
Comparative Medicine
Primary
Titles
Director, Molecular and Serological Diagnostics, Comparative Medicine
Contact Info
Comparative Medicine
PO Box 208016
New Haven, CT 06520-8016
United States
Appointments
Comparative Medicine
Primary
Titles
Director, Molecular and Serological Diagnostics, Comparative Medicine
Contact Info
Comparative Medicine
PO Box 208016
New Haven, CT 06520-8016
United States
Appointments
Comparative Medicine
Primary
Titles
Director, Molecular and Serological Diagnostics, Comparative Medicine
Contact Info
Comparative Medicine
PO Box 208016
New Haven, CT 06520-8016
United States
About
Titles
Senior Research Scientist in Comparative Medicine
Director, Molecular and Serological Diagnostics, Comparative MedicineBiography
The Compton laboratory studies the diagnosis, pathogenesis, transmission and prevention of viral infections of rodents.
Appointments
Comparative Medicine
Senior Research Scientist Phased RetirementPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Fellow
- University of Colorado (1990)
- PhD
- Uniformed Services University (1988)
- BS
- Bucknell University, Biology (1981)
Research
Overview
Medical Subject Headings (MeSH)
Bacterial Infections and Mycoses; Coronavirus; DNA Virus Infections; Ectoparasitic Infestations; Norovirus; Organisms; Parvovirus; RNA Virus Infections; Rodent Diseases; Viral Zoonoses; Virus Diseases; Zoonoses
ORCID
0000-0001-9644-1561
Research at a Glance
Yale Co-Authors
Frequent collaborators of Susan Compton's published research.
Publications Timeline
A big-picture view of Susan Compton's research output by year.
Research Interests
Research topics Susan Compton is interested in exploring.
Caroline Zeiss, DACVP, DACLAM
Brent Vander Wyk, PhD
Heather Allore, PhD
Craig B. Wilen, MD, PhD
James Macy Jr, DVM
Madison S. Strine, PhD
25Publications
228Citations
Rodent Diseases
Parvovirus
Coronavirus
Virus Diseases
Publications
2023
The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression
Wei J, Alfajaro M, Cai W, Graziano V, Strine M, Filler R, Biering S, Sarnik S, Patel S, Menasche B, Compton S, Konermann S, Hsu P, Orchard R, Yan Q, Wilen C. The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression. PLOS Pathogens 2023, 19: e1011351. PMID: 37410700, PMCID: PMC10325096, DOI: 10.1371/journal.ppat.1011351.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsMouse hepatitis virusReceptor expressionTherapeutic targetMERS-CoVMajor SARS-CoV-2 variantsPrimary human airwaySARS-CoV-2 variantsNovel therapeutic targetViral receptor expressionSARS-CoV-2Histone methyltransferase KMT2DIntestinal epithelial cellsCoronavirus SusceptibilityDiverse coronavirusesHistone demethylase KDM6ADPP4 expressionCoronavirus receptorsHost determinantsHepatitis virusHuman airwaysSARS-CoVSmall molecule inhibitionViral entryPotential drug targetsViral receptors
2022
Modeling pandemic to endemic patterns of SARS-CoV-2 transmission using parameters estimated from animal model data
Mullin S, Vander Wyk B, Asher JL, Compton SR, Allore HG, Zeiss CJ. Modeling pandemic to endemic patterns of SARS-CoV-2 transmission using parameters estimated from animal model data. PNAS Nexus 2022, 1: pgac096. PMID: 35799833, PMCID: PMC9254158, DOI: 10.1093/pnasnexus/pgac096.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSARS-CoV-2 transmissionNatural infectionDuration of immunitySARS-CoV-2 pandemicAnimal model dataEndemic stateHeterologous vaccinationMedian timeCoronaviral diseaseDeterministic compartmental modelNatural immunityLow prevalenceCoronaviral infectionVaccinationViral transmissionInfectionTransmissible variantsImmunityEndemic patternReinfection dataNatural exposureReinfectionEndemic stabilityVariable durationAnimals
2021
Modeling SARS-CoV-2 propagation using rat coronavirus-associated shedding and transmission
Zeiss CJ, Asher JL, Wyk B, Allore HG, Compton SR. Modeling SARS-CoV-2 propagation using rat coronavirus-associated shedding and transmission. PLOS ONE 2021, 16: e0260038. PMID: 34813610, PMCID: PMC8610237, DOI: 10.1371/journal.pone.0260038.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsViral sheddingSialodacryoadenitis virusSARS-CoV-2Prior natural infectionSARS-CoV-2 propagationSeropositive animalsLow-level sheddingNaive recipient ratsCOVID-19Cycle threshold valuesDirect contact exposureSeroconversion ratesReinfected animalsRecipient ratsImmune protectionHigh riskNaive animalsSusceptible individualsInitial infectionGlobal immunityExposure paradigmRat coronavirusNatural infectionInfectionRatsOverview of Coronaviruses in Veterinary Medicine.
Compton SR. Overview of Coronaviruses in Veterinary Medicine. Comparative Medicine 2021, 71: 333-341. PMID: 34412731, PMCID: PMC8594256, DOI: 10.30802/aalas-cm-21-000007.Peer-Reviewed Original ResearchCitationsAltmetricAnimal Models of COVID-19. I. Comparative Virology and Disease Pathogenesis
Zeiss CJ, Compton S, Veenhuis RT. Animal Models of COVID-19. I. Comparative Virology and Disease Pathogenesis. ILAR Journal 2021, 62: ilab007-. PMID: 33836527, PMCID: PMC8083356, DOI: 10.1093/ilar/ilab007.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSARS-CoV-2SARS-CoVViral sheddingImmune responseSpontaneous modelAnimal modelsDisease pathogenesisSARS-CoV-2 infectionCOVID-19Severe acute respiratory syndrome coronavirusAcute respiratory syndrome coronavirusChimeric SARS-CoVRole of comorbiditiesCoronavirus disease 2019 (COVID-19) pandemicShort-term immune responseWild-type miceSeverity of diseaseOrgan-specific pathologySARS-CoV-2 virusDisease 2019 pandemicAfrican green monkeysTest therapeuticsVaccine approachesNonfatal diseaseTissue involvement
2020
Cutaneous and Pulmonary Mucormycosis in Rag1- and Il2rg-deficient Rats.
Sarfaty AE, Compton SR, Smith PC, Zeiss CJ. Cutaneous and Pulmonary Mucormycosis in Rag1- and Il2rg-deficient Rats. Comparative Medicine 2020, 70: 390-395. PMID: 32736665, PMCID: PMC7446636, DOI: 10.30802/aalas-cm-20-000015.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsPCR and RT-PCR in the Diagnosis of Laboratory Animal Infections and in Health Monitoring.
Compton SR. PCR and RT-PCR in the Diagnosis of Laboratory Animal Infections and in Health Monitoring. Journal Of The American Association For Laboratory Animal Science 2020, 59: 458-468. PMID: 32580820, PMCID: PMC7479767, DOI: 10.30802/aalas-jaalas-20-000008.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2019
Transverse myelitis following measles vaccination in a rhesus macaque (Macaca mulatta)
Sarfaty AE, Fulbright RK, Compton SR, Asher JL, Zeiss CJ. Transverse myelitis following measles vaccination in a rhesus macaque (Macaca mulatta). Journal Of Medical Primatology 2019, 49: 103-106. PMID: 31789460, DOI: 10.1111/jmp.12453.Peer-Reviewed Original ResearchChapter 13 Viral Disease
Macy J, Compton S. Chapter 13 Viral Disease. 2019, 541-568. PMCID: PMC7153344, DOI: 10.1016/b978-0-12-814338-4.00013-1.Peer-Reviewed Original ResearchCitationsAltmetric
2017
Lack of Effect of Murine Astrovirus Infection on Dextran Sulfate-induced Colitis in NLRP3-deficient Mice.
Compton SR, Booth CJ, Macy JD. Lack of Effect of Murine Astrovirus Infection on Dextran Sulfate-induced Colitis in NLRP3-deficient Mice. Comparative Medicine 2017, 67: 400-406. PMID: 28935001, PMCID: PMC5621567.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsAstroviridaeAstroviridae InfectionsColitisColonDextran SulfateDisease Models, AnimalFemaleGastrointestinal MicrobiomeInflammasomesMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinRandom AllocationReal-Time Polymerase Chain ReactionReproducibility of ResultsRodent DiseasesRodentiaConceptsColitis modelInflammatory bowel disease researchNOD-like receptor 3Induced colitis modelSeverity of colitisDextran sodium sulfateDSS colitis modelNLRP3-deficient miceDefective inflammasome activationLack of effectMucosal ulcerationIntestinal inflammationHistopathologic changesIntestinal permeabilityAstrovirus infectionFemale miceClinical signsDeficient miceNLRP3 mutationsClinical diseaseInflammasome activationGastrointestinal tractMurine astrovirusIntestinal bacteriaIntestinal epithelium
Academic Achievements and Community Involvement
activity Associate Editor
Journal ServiceAmerican Association for Laboratory ScienceDetails2000 - Presenthonor Pravin N. Bhatt Scientific Investigator Award
National AwardAmerican Association for Laboratory Animal ScienceDetails10/12/2019United Stateshonor Honarary Diplomate
National AwardAmerican College of Laboratory Animal MedicineDetails05/01/2018United States
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Lab Number
Mailing Address
Comparative Medicine
PO Box 208016
New Haven, CT 06520-8016
United States