Weichang Zhang
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Associate Research Scientist
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Vascular Surgery & Endovascular Therapy
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Frequent collaborators of Weichang Zhang's published research.
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A big-picture view of Weichang Zhang's research output by year.
Alan Dardik, MD/PhD, FACS, DFSVS, FAHA
Yuichi Ohashi, MD
Bogdan Yatsula, PhD
John Langford, MD
Luis Gonzalez
Eric B Schneider, PhD
19Publications
108Citations
Publications
2024
The predictive role of the platelet-to-lymphocyte ratio for the risk of non-alcoholic fatty liver disease and cirrhosis: a nationwide cross-sectional study
Yan C, Zhang W, Xiao Y, Sun Y, Peng X, Cai W. The predictive role of the platelet-to-lymphocyte ratio for the risk of non-alcoholic fatty liver disease and cirrhosis: a nationwide cross-sectional study. Frontiers In Endocrinology 2024, 15: 1376894. DOI: 10.3389/fendo.2024.1376894.Peer-Reviewed Original ResearchConceptsPlatelet-to-lymphocyte ratioNon-alcoholic fatty liver diseaseNAFLD populationRestricted cubic splinesFatty liver diseasePatients progress to cirrhosisNondiabetic populationLiver diseaseDiabetic populationNational Health and Nutrition Examination SurveyRisk of non-alcoholic fatty liver diseaseAssociated with non-alcoholic fatty liver diseaseHealth and Nutrition Examination SurveyAssociated with cirrhosisTwo-piecewise linear regressionProgression to cirrhosisNutrition Examination SurveyLogistic regression analysisNationwide cross-sectional studyMonitoring disease progressionCross-sectional studyNAFLD incidenceDisease progressionCirrhosisExamination SurveyHeterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling
Ohashi Y, Protack C, Aoyagi Y, Gonzalez L, Thaxton C, Zhang W, Kano M, Bai H, Yatsula B, Alves R, Hoshina K, Schneider E, Long X, Perry R, Dardik A. Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling. Scientific Reports 2024, 14: 13287. PMID: 38858395, PMCID: PMC11164895, DOI: 10.1038/s41598-024-64075-8.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsGene expression patternsArteriovenous fistula groupArteriovenous fistulaExpression patternsHeterogeneous gene expressionGene expression changesOutcomes of arteriovenous fistulaVenous remodelingArteriovenous fistula maturationPostoperative day 7Reduce patient morbidityRNA sequencingUpregulation of metabolismBioinformatics analysisGene expressionDownregulation of metabolismMetabolic pathwaysExpression changesGenesAVF maturationAVF remodelingFistula creationC57BL/6 miceClinical outcomesPatient morbidityDisturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia
Bai H, Varsanik M, Thaxton C, Ohashi Y, Gonzalez L, Zhang W, Aoyagi Y, Kano M, Yatsula B, Li Z, Pocivavsek L, Dardik A. Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia. AJP Heart And Circulatory Physiology 2024, 326: h1446-h1461. PMID: 38578237, DOI: 10.1152/ajpheart.00054.2024.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEndothelial cell lossOutflow veinChronic kidney diseaseJuxta-anastomotic areaMouse AVF modelNeointimal hyperplasiaThrombus formationAcute thrombus formationCell lossHuman AVF maturationGene OntologyAVF maturationAVF patencyEarly thrombus formationArteriovenous fistulaC57BL/6 miceClinical failureWistar ratsEndothelial lossKidney diseaseImmune responseEndothelial cellsHyperplasiaMiceAVFA central arteriovenous fistula reduces systemic hypertension in a mouse model
Brahmandam A, Alves R, Liu H, Gonzalez L, Aoyagi Y, Ohashi Y, Langford J, Thaxton C, Taniguchi R, Zhang W, Bai H, Yatsula B, Dardik A. A central arteriovenous fistula reduces systemic hypertension in a mouse model. JVS Vascular Science 2024, 5: 100191. PMID: 38510938, PMCID: PMC10951512, DOI: 10.1016/j.jvssci.2024.100191.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCentral arteriovenous fistulaArteriovenous fistulaBlood pressureAng IISystemic hypertensionVenous remodelingArteriovenous fistula creationPCNA-positive cellsPostoperative day 7Systemic blood pressureSystolic blood pressureCollagen I depositionNormotensive miceRefractory hypertensionHypertensive miceC57BL6/J miceHypertensive environmentTreated patientsAngiotensin IIMouse modelDay 7HypertensionMiceFistulaAng
2023
EphB4 monomer inhibits chronic graft vasculopathy in an aortic transplant model
Langford J, Gonzalez L, Taniguchi R, Brahmandam A, Zhang W, Dardik A. EphB4 monomer inhibits chronic graft vasculopathy in an aortic transplant model. JVS Vascular Science 2023, 4: 100109. PMID: 37519335, PMCID: PMC10372308, DOI: 10.1016/j.jvssci.2023.100109.Peer-Reviewed Original ResearchConceptsAortic transplant modelAllograft vasculopathyT cellsTransplant modelEphrin-B2Immune cell accumulationChronic graftCardiac transplantChronic rejectionTransplanted graftAortic allograftsNeointima formationCell accumulationTissue damageMonocyte adhesionLess neointima formationVasculopathyAdherent monocytesEndothelial surfaceReceptor EphB4MacrophagesGraftMonocytesImportant targetCellsSex hormones impact early maturation and immune response in the arteriovenous fistula mouse model
Satam K, Ohashi Y, Thaxton C, Gonzalez L, Setia O, Bai H, Aoyagi Y, Xie Y, Zhang W, Yatsula B, Martin K, Cai Y, Dardik A. Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model. AJP Heart And Circulatory Physiology 2023, 325: h77-h88. PMID: 37145957, PMCID: PMC10243550, DOI: 10.1152/ajpheart.00049.2023.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIntact female miceAVF maturationSex hormonesT cellsFemale miceArteriovenous fistulaMale miceMouse modelHigher IL-10Arteriovenous fistula creationImmune cell recruitmentSex-specific therapiesHormone receptor signalingSex differencesHuman AVF maturationAVF surgeryMale patientsClinical outcomesFemale patientsFistula maturationIL-10C57BL/6 miceInferior outcomesVenous adaptationFistula creationEndothelial Glucocorticoid Receptor Deficiency Affects Arteriovenous Fistula Maturation
Zhang W, Gonzalez L, Thaxton C, Ohashi Y, Aoyagi Y, Xie Y, Cai Y, Shu C, Goodwin J, Dardik A. Endothelial Glucocorticoid Receptor Deficiency Affects Arteriovenous Fistula Maturation. JVS Vascular Science 2023, 4: 100147. DOI: 10.1016/j.jvssci.2023.100147.Peer-Reviewed Original Research
2022
First-in-Human Implantation of Gutter-Free Design Stent-Graft in in situ Fenestration TEVAR for Aortic Arch Pathology
Li X, Shu C, Wang L, Li Q, Fang K, Luo M, Zhang W, Zhou Y, Zhou H. First-in-Human Implantation of Gutter-Free Design Stent-Graft in in situ Fenestration TEVAR for Aortic Arch Pathology. Frontiers In Cardiovascular Medicine 2022, 9: 911689. PMID: 35845060, PMCID: PMC9279855, DOI: 10.3389/fcvm.2022.911689.Peer-Reviewed Original ResearchCitationsAltmetricConceptsThoracic endovascular aortic repairAortic stent graftStent graftPolytetrafluoroethylene coatingSkirt structurePrevention of endoleaksLeft subclavian arteryAortic arch aneurysmAortic arch pathologiesEndovascular aortic repairFuture multi-centre studiesMulti-center studyFabric structureStent graft fenestrationLocalized dissectionArch aneurysmArch pathologiesAortic repairSubclavian arteryLong-term evaluationGraft fenestrationGraftHuman implantationEndoleakEndograftSex differences in arterial identity correlate with neointimal hyperplasia after balloon injury
Gao M, Gao X, Taniguchi R, Brahmandam A, Matsubara Y, Liu J, Liu H, Zhang W, Dardik A. Sex differences in arterial identity correlate with neointimal hyperplasia after balloon injury. Molecular Biology Reports 2022, 49: 8301-8315. PMID: 35715609, PMCID: PMC9463237, DOI: 10.1007/s11033-022-07644-2.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsBalloon injuryFemale ratsArterial remodelingNeointimal proliferationCarotid arteryNeointimal thicknessSex differencesLeft common carotid arteryAtherosclerotic arterial diseaseSmooth muscle cell proliferationRight carotid arteryCarotid balloon injuryMale Sprague-DawleyCommon carotid arteryBaseline sex differencesMuscle cell proliferationErythropoietin-producing hepatocellular (Eph) receptorsBackgroundEndovascular treatmentArterial diseaseArterial injuryClinical outcomesSex hormonesUninjured controlsArterial identitySprague-DawleySimultaneous Endovascular Repair Is Not Associated With Increased Risk for Thoracic and Abdominal Aortic Pathologies: Early and Midterm Outcomes
Zhang W, Zhang L, Li X, Li M, Qiu J, Wang M, Shu C. Simultaneous Endovascular Repair Is Not Associated With Increased Risk for Thoracic and Abdominal Aortic Pathologies: Early and Midterm Outcomes. Frontiers In Cardiovascular Medicine 2022, 9: 883708. PMID: 35711338, PMCID: PMC9197242, DOI: 10.3389/fcvm.2022.883708.Peer-Reviewed Original ResearchCitationsConceptsThoracic endovascular repairEndovascular aneurysm repairAortic pathologyEndovascular repairMean survival rateSurvival rateSimultaneous endovascular repairAbdominal aortic diseaseAbdominal aortic pathologyMaximal aortic diameterConcomitant thoracicHospital stayMidterm outcomesPostoperative complicationsAortic repairPostoperative outcomesRepair patientsAneurysm repairSingle centerAortic diameterAortic diseaseMinimal morbidityAortic segmentsEffective treatmentProcedure time