Yale researchers have introduced countless medical and health advances over the last century, including the first success with antibiotics in the United States and the first use of chemotherapy to treat cancer. University scientists have been responsible for the identification of Lyme disease and the discovery of genes responsible for high blood pressure, osteoporosis, dyslexia, and Tourette's syndrome, among other disorders. Early work on the artificial heart and the creation of the first insulin pump took place at Yale, as did seminal discoveries about how the cell and its components function at the molecular level. Today, research activities take place in a wide range of departments, programs, and centers.
As of fiscal year 2013 Yale research has had 1,815 awards totaling $510.4 million, 416 U.S. and 704 worldwide active patents for Yale inventions, and 58 Yale-founded biotech companies.
The School of Medicine has extraordinary strength in the basic sciences and consistently ranks in the top handful of medical schools receiving funding from the National Institutes of Health.
Productive and prominent programs in both basic and clinical research are fundamental to the development of clinical excellence and our academic mission.
Dr. Naiem Nassiri’s research focuses in part on clinical trials evaluating the safety and efficacy of Endovascular technology for treatment of aortic pathology and critical limb ischemia, including stent graft and adjunctive fixation technology, drug eluting stents, and outcome studies. Dr. Nassiri is also involved in on-going clinical trials investigating the safety and efficacy of customized non-surgical compression apparatus for management of venolymphatic insufficiency. Dr. Nassiri collaborates with colleagues in dermatology and is co-director of the HHT & Vascular Anomalies Program; this program is involved in a funded trial to examine the pathogenesis and function of novel genes causing cutaneous and vascular mosaic disorders. Dr Nassiri also studies targeted delivery of molecularly active therapies for treatment of slow-flow vascular Malformations, and is involved in developing in vascular applications for HIFU ( High Intensity Focused Ultrasound) technology through collaboration with YCCI and industry representatives.
Dr Jonathan Cardella’s research interest lie in two main areas. The first is the use of handheld thermal imaging as a diagnostic tool in Vascular Surgery. We currently have several studies on going where we are evaluating thermal imaging in the diagnosis and treatment of PAD. Furthermore, we are evaluating as a predictive tool in the creation of dialysis access fistulas as well as a diagnostic adjunct in dialysis access steal syndrome. Dr. Cardella is also active in educational research and has started a study to evaluate surgical autonomy.
Dr Cassius Chaar’s research focuses on clinical outcomes using large national database analysis. He also leads multiple clinical trials at Yale New Haven Hospital. Dr Chaar studies and publishes on various aspects of vascular disease including peripheral artery disease, varicose veins, venous thromboembolism, and aortic aneurysms.
Dr. Alan Dardik is a surgeon-scientist who seeks to use the power of molecular biology to achieve a modern understanding of vascular disease, and to use the basic science laboratory to perform cutting edge research to ultimately benefit patients with vascular disease. The Dardik laboratory studies the healing and function of blood vessels and synthetic blood vessel substitutes that are used in patients having vascular surgery. Current focus is mainly in understanding venous adaptation such as occurs during vein bypass adaptation and arteriovenous fistula maturation, delivery of stem cells to diabetic ulcers, and understanding patch healing during blood vessel closure. The laboratory is funded from NIH NHLBI and the VA, as well as from the Yale Department of Surgery. As part of Yale's Vascular Biology and Therapeutics program, the lab is located on the 4th floor of the Amistad building. Members of the Dardik laboratory include surgery residents from Yale and other programs as well as postdoctoral fellows and students from around the world.