2024
The predictive role of the platelet-to-lymphocyte ratio for the risk of non-alcoholic fatty liver disease and cirrhosis: a nationwide cross-sectional study
Yan C, Zhang W, Xiao Y, Sun Y, Peng X, Cai W. The predictive role of the platelet-to-lymphocyte ratio for the risk of non-alcoholic fatty liver disease and cirrhosis: a nationwide cross-sectional study. Frontiers In Endocrinology 2024, 15: 1376894. DOI: 10.3389/fendo.2024.1376894.Peer-Reviewed Original ResearchPlatelet-to-lymphocyte ratioNon-alcoholic fatty liver diseaseNAFLD populationRestricted cubic splinesFatty liver diseasePatients progress to cirrhosisNondiabetic populationLiver diseaseDiabetic populationNational Health and Nutrition Examination SurveyRisk of non-alcoholic fatty liver diseaseAssociated with non-alcoholic fatty liver diseaseHealth and Nutrition Examination SurveyAssociated with cirrhosisTwo-piecewise linear regressionProgression to cirrhosisNutrition Examination SurveyLogistic regression analysisNationwide cross-sectional studyMonitoring disease progressionCross-sectional studyNAFLD incidenceDisease progressionCirrhosisExamination SurveyHeterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling
Ohashi Y, Protack C, Aoyagi Y, Gonzalez L, Thaxton C, Zhang W, Kano M, Bai H, Yatsula B, Alves R, Hoshina K, Schneider E, Long X, Perry R, Dardik A. Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling. Scientific Reports 2024, 14: 13287. PMID: 38858395, PMCID: PMC11164895, DOI: 10.1038/s41598-024-64075-8.Peer-Reviewed Original ResearchConceptsGene expression patternsArteriovenous fistula groupArteriovenous fistulaExpression patternsHeterogeneous gene expressionGene expression changesOutcomes of arteriovenous fistulaVenous remodelingArteriovenous fistula maturationPostoperative day 7Reduce patient morbidityRNA sequencingUpregulation of metabolismBioinformatics analysisGene expressionDownregulation of metabolismMetabolic pathwaysExpression changesGenesAVF maturationAVF remodelingFistula creationC57BL/6 miceClinical outcomesPatient morbidityDisturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia
Bai H, Varsanik M, Thaxton C, Ohashi Y, Gonzalez L, Zhang W, Aoyagi Y, Kano M, Yatsula B, Li Z, Pocivavsek L, Dardik A. Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia. AJP Heart And Circulatory Physiology 2024, 326: h1446-h1461. PMID: 38578237, DOI: 10.1152/ajpheart.00054.2024.Peer-Reviewed Original ResearchConceptsEndothelial cell lossOutflow veinChronic kidney diseaseJuxta-anastomotic areaMouse AVF modelNeointimal hyperplasiaThrombus formationAcute thrombus formationCell lossHuman AVF maturationGene OntologyAVF maturationAVF patencyEarly thrombus formationArteriovenous fistulaC57BL/6 miceClinical failureWistar ratsEndothelial lossKidney diseaseImmune responseEndothelial cellsHyperplasiaMiceAVFA central arteriovenous fistula reduces systemic hypertension in a mouse model
Brahmandam A, Alves R, Liu H, Gonzalez L, Aoyagi Y, Ohashi Y, Langford J, Thaxton C, Taniguchi R, Zhang W, Bai H, Yatsula B, Dardik A. A central arteriovenous fistula reduces systemic hypertension in a mouse model. JVS Vascular Science 2024, 5: 100191. PMID: 38510938, PMCID: PMC10951512, DOI: 10.1016/j.jvssci.2024.100191.Peer-Reviewed Original ResearchCentral arteriovenous fistulaArteriovenous fistulaBlood pressureAng IISystemic hypertensionVenous remodelingArteriovenous fistula creationPCNA-positive cellsPostoperative day 7Systemic blood pressureSystolic blood pressureCollagen I depositionNormotensive miceRefractory hypertensionHypertensive miceC57BL6/J miceHypertensive environmentTreated patientsAngiotensin IIMouse modelDay 7HypertensionMiceFistulaAng
2023
EphB4 monomer inhibits chronic graft vasculopathy in an aortic transplant model
Langford J, Gonzalez L, Taniguchi R, Brahmandam A, Zhang W, Dardik A. EphB4 monomer inhibits chronic graft vasculopathy in an aortic transplant model. JVS Vascular Science 2023, 4: 100109. PMID: 37519335, PMCID: PMC10372308, DOI: 10.1016/j.jvssci.2023.100109.Peer-Reviewed Original ResearchAortic transplant modelAllograft vasculopathyT cellsTransplant modelEphrin-B2Immune cell accumulationChronic graftCardiac transplantChronic rejectionTransplanted graftAortic allograftsNeointima formationCell accumulationTissue damageMonocyte adhesionLess neointima formationVasculopathyAdherent monocytesEndothelial surfaceReceptor EphB4MacrophagesGraftMonocytesImportant targetCellsSex hormones impact early maturation and immune response in the arteriovenous fistula mouse model
Satam K, Ohashi Y, Thaxton C, Gonzalez L, Setia O, Bai H, Aoyagi Y, Xie Y, Zhang W, Yatsula B, Martin K, Cai Y, Dardik A. Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model. AJP Heart And Circulatory Physiology 2023, 325: h77-h88. PMID: 37145957, PMCID: PMC10243550, DOI: 10.1152/ajpheart.00049.2023.Peer-Reviewed Original ResearchConceptsIntact female miceAVF maturationSex hormonesT cellsFemale miceArteriovenous fistulaMale miceMouse modelHigher IL-10Arteriovenous fistula creationImmune cell recruitmentSex-specific therapiesHormone receptor signalingSex differencesHuman AVF maturationAVF surgeryMale patientsClinical outcomesFemale patientsFistula maturationIL-10C57BL/6 miceInferior outcomesVenous adaptationFistula creationEndothelial Glucocorticoid Receptor Deficiency Affects Arteriovenous Fistula Maturation
Zhang W, Gonzalez L, Thaxton C, Ohashi Y, Aoyagi Y, Xie Y, Cai Y, Shu C, Goodwin J, Dardik A. Endothelial Glucocorticoid Receptor Deficiency Affects Arteriovenous Fistula Maturation. JVS Vascular Science 2023, 4: 100147. DOI: 10.1016/j.jvssci.2023.100147.Peer-Reviewed Original Research
2022
First-in-Human Implantation of Gutter-Free Design Stent-Graft in in situ Fenestration TEVAR for Aortic Arch Pathology
Li X, Shu C, Wang L, Li Q, Fang K, Luo M, Zhang W, Zhou Y, Zhou H. First-in-Human Implantation of Gutter-Free Design Stent-Graft in in situ Fenestration TEVAR for Aortic Arch Pathology. Frontiers In Cardiovascular Medicine 2022, 9: 911689. PMID: 35845060, PMCID: PMC9279855, DOI: 10.3389/fcvm.2022.911689.Peer-Reviewed Original ResearchThoracic endovascular aortic repairAortic stent graftStent graftPolytetrafluoroethylene coatingSkirt structurePrevention of endoleaksLeft subclavian arteryAortic arch aneurysmAortic arch pathologiesEndovascular aortic repairFuture multi-centre studiesMulti-center studyFabric structureStent graft fenestrationLocalized dissectionArch aneurysmArch pathologiesAortic repairSubclavian arteryLong-term evaluationGraft fenestrationGraftHuman implantationEndoleakEndograftSex differences in arterial identity correlate with neointimal hyperplasia after balloon injury
Gao M, Gao X, Taniguchi R, Brahmandam A, Matsubara Y, Liu J, Liu H, Zhang W, Dardik A. Sex differences in arterial identity correlate with neointimal hyperplasia after balloon injury. Molecular Biology Reports 2022, 49: 8301-8315. PMID: 35715609, PMCID: PMC9463237, DOI: 10.1007/s11033-022-07644-2.Peer-Reviewed Original ResearchConceptsBalloon injuryFemale ratsArterial remodelingNeointimal proliferationCarotid arteryNeointimal thicknessSex differencesLeft common carotid arteryAtherosclerotic arterial diseaseSmooth muscle cell proliferationRight carotid arteryCarotid balloon injuryMale Sprague-DawleyCommon carotid arteryBaseline sex differencesMuscle cell proliferationErythropoietin-producing hepatocellular (Eph) receptorsBackgroundEndovascular treatmentArterial diseaseArterial injuryClinical outcomesSex hormonesUninjured controlsArterial identitySprague-DawleySimultaneous Endovascular Repair Is Not Associated With Increased Risk for Thoracic and Abdominal Aortic Pathologies: Early and Midterm Outcomes
Zhang W, Zhang L, Li X, Li M, Qiu J, Wang M, Shu C. Simultaneous Endovascular Repair Is Not Associated With Increased Risk for Thoracic and Abdominal Aortic Pathologies: Early and Midterm Outcomes. Frontiers In Cardiovascular Medicine 2022, 9: 883708. PMID: 35711338, PMCID: PMC9197242, DOI: 10.3389/fcvm.2022.883708.Peer-Reviewed Original ResearchThoracic endovascular repairEndovascular aneurysm repairAortic pathologyEndovascular repairMean survival rateSurvival rateSimultaneous endovascular repairAbdominal aortic diseaseAbdominal aortic pathologyMaximal aortic diameterConcomitant thoracicHospital stayMidterm outcomesPostoperative complicationsAortic repairPostoperative outcomesRepair patientsAneurysm repairSingle centerAortic diameterAortic diseaseMinimal morbidityAortic segmentsEffective treatmentProcedure timeEndothelial Cell TGF-β (Transforming Growth Factor-Beta) Signaling Regulates Venous Adaptive Remodeling to Improve Arteriovenous Fistula Patency
Taniguchi R, Ohashi Y, Lee JS, Hu H, Gonzalez L, Zhang W, Langford J, Matsubara Y, Yatsula B, Tellides G, Fahmy TM, Hoshina K, Dardik A. Endothelial Cell TGF-β (Transforming Growth Factor-Beta) Signaling Regulates Venous Adaptive Remodeling to Improve Arteriovenous Fistula Patency. Arteriosclerosis Thrombosis And Vascular Biology 2022, 42: 868-883. PMID: 35510552, PMCID: PMC9233042, DOI: 10.1161/atvbaha.122.317676.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaSMC proliferationAVF patencyCollagen densityMouse aortocaval fistula modelTGF-β receptor IArteriovenous fistula patencyAortocaval fistula modelInhibition of TGFPredetermined time pointsTGF-β inhibitionTGF-β signalingTGF-β receptorDisruption of TGFFistula patencyAVF failureWall thicknessVascular accessVenous remodelingSuccessful hemodialysisDoppler ultrasoundFistula modelReceptor IPatencyTGF
2021
Roles of MicroRNAs in Peripheral Artery In-Stent Restenosis after Endovascular Treatment
Wang M, Zhang W, Zhang L, Wang L, Li J, Shu C, Li X. Roles of MicroRNAs in Peripheral Artery In-Stent Restenosis after Endovascular Treatment. BioMed Research International 2021, 2021: 9935671. PMID: 34368362, PMCID: PMC8337102, DOI: 10.1155/2021/9935671.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal angioplastyEndovascular repairStent restenosisPeripheral arterial diseaseNovel therapeutic targetPotential therapeutic strategyMajor pathological processesTransluminal angioplastyArterial diseaseEndovascular treatmentLimited complicationsPeripheral arteriesStent implantationEndothelial denudationInflammatory responseClinical studiesNeointimal hyperplasiaTherapeutic strategiesRole of microRNAsTherapeutic targetRestenosisPathological processesLong-term successRole of miRNAsUnderlying mechanism
2020
Diagnosis and outcomes of surgical treatment of carotid bifurcation tumors
Li X, Zhang W, Shu C, Li Q, Zhang L, Zhu J. Diagnosis and outcomes of surgical treatment of carotid bifurcation tumors. Journal Of International Medical Research 2020, 48: 0300060520976495. PMID: 33317387, PMCID: PMC7739102, DOI: 10.1177/0300060520976495.Peer-Reviewed Original ResearchConceptsOperative timeBifurcation tumorsBlood lossClinicopathological featuresShamblin type ICarotid body tumorLymph node metastasisMean tumor volumePatients' clinicopathological featuresSpearman correlation analysisMalignant CBTsPostoperative complicationsComplication gradeConservative treatmentSurgical complicationsNode metastasisSurgical treatmentBody tumorsExamination findingsPathological examinationSurgical managementRetrospective studySurgical difficultyTumor sizeFrequent lesionsShort-term results in canines of novel stent-graft design for chimney technique in TEVAR
Li M, Shu C, Xiao B, Liu D, Zhang W. Short-term results in canines of novel stent-graft design for chimney technique in TEVAR. Journal Of Interventional Medicine 2020, 3: 128-131. PMID: 34805922, PMCID: PMC8562206, DOI: 10.1016/j.jimed.2020.07.004.Peer-Reviewed Original ResearchThoracic endovascular aortic repairDigital subtraction angiographyChimney techniqueHistopathologic examinationCompletion digital subtraction angiographyGross necropsy observationsMid-term resultsEndovascular aortic repairSupra-aortic branchesStent Graft SystemShort-term resultsStent-graft designPre-operative dataEndoleak rateArtery approachAortic angiographyAortic repairAortic pathologyGeneral anesthesiaEndovascular techniquesAortic archMural thrombusNecropsy observationsThoracic aortaAbdominal aorta
2019
Contrast-Induced Kidney Nephropathy in Thoracic Endovascular Aortic Repair: A 2-Year Retrospective Study in 470 Patients
Li X, Zhang W, Liu J, Gonzalez L, Liu D, Zhang L, Dardik A, Shu C. Contrast-Induced Kidney Nephropathy in Thoracic Endovascular Aortic Repair: A 2-Year Retrospective Study in 470 Patients. Angiology 2019, 71: 242-248. PMID: 31829038, DOI: 10.1177/0003319719893578.Peer-Reviewed Original ResearchConceptsThoracic endovascular aortic repairContrast-induced nephropathyEndovascular aortic repairContrast volumeRenal functionAortic dissectionAortic repairRenal arteryRisk factorsRenal artery involvementRenal failure rateKaplan-Meier curvesSerum urea nitrogenArtery involvementRenal comorbiditiesInjury groupSerum creatinineConsecutive patientsKidney functionRetrospective studyKidney nephropathyRenal pathologyUrea nitrogenSurvival rateLogistic regressionEarly experience and technical aspects of physician-modified fenestration in thoracic endovascular aortic repair for aortic arch pathologies
Li X, Li Q, Zhang W, Li M, He H, Luo M, Fang K, Yang C, Zhu J, Shu C. Early experience and technical aspects of physician-modified fenestration in thoracic endovascular aortic repair for aortic arch pathologies. Journal Of International Medical Research 2019, 48: 0300060519870903. PMID: 31547732, PMCID: PMC7607183, DOI: 10.1177/0300060519870903.Peer-Reviewed Original ResearchConceptsThoracic endovascular aortic repairAortic arch pathologiesLeft subclavian arteryEndovascular aortic repairArch pathologiesAortic repairClinical dataBranch arteriesCause survival ratesMiddle-term resultsMean procedure timeCommon carotid arteryPatients' clinical dataFenestration techniqueGraphPad Prism 7.0Mean followSubclavian arteryPatency ratesCarotid arteryProcedure timeProximal diameterSurvival rateArteryPathologyMean lengthComparison of clinical outcomes of laparoscopic versus open surgery for recurrent hepatocellular carcinoma: a meta-analysis
Cai W, Liu Z, Xiao Y, Zhang W, Tang D, Cheng B, Li Q. Comparison of clinical outcomes of laparoscopic versus open surgery for recurrent hepatocellular carcinoma: a meta-analysis. Surgical Endoscopy 2019, 33: 3550-3557. PMID: 31342257, DOI: 10.1007/s00464-019-06996-4.Peer-Reviewed Original ResearchConceptsRecurrent hepatocellular carcinomaOpen liver resectionLaparoscopic liver resectionShorter postoperative hospital stayPostoperative hospital stayLiver resectionLess blood lossLaparoscopic groupHospital stayBlood lossClinical outcomesOperative timeOpen groupHepatocellular carcinomaSafe alternative treatment strategyConclusionLaparoscopic liver resectionHospital complication ratesSatisfactory postoperative outcomeSimilar operative timeAlternative treatment strategiesHospital complicationsComplication ratePostoperative outcomesOpen surgeryResultsSix studiesMidterm Outcomes of Endovascular Repair for Stanford Type B Aortic Dissection with Aberrant Right Subclavian Artery
Zhang W, Li X, Cai W, Li M, Qiu J, Shu C. Midterm Outcomes of Endovascular Repair for Stanford Type B Aortic Dissection with Aberrant Right Subclavian Artery. Journal Of Vascular And Interventional Radiology 2019, 30: 1378-1385. PMID: 31133449, DOI: 10.1016/j.jvir.2019.02.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAortic AneurysmAortic DissectionBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationCardiovascular AbnormalitiesEndovascular ProceduresFemaleHumansMaleMiddle AgedOperative TimePostoperative ComplicationsProsthesis DesignRetrospective StudiesRisk FactorsStentsSubclavian ArteryTime FactorsTreatment OutcomeConceptsAberrant right subclavian arteryType B aortic dissectionStanford type B aortic dissectionThoracic endovascular aortic repairRight subclavian arteryB aortic dissectionEndovascular repairKommerell's diverticulumMidterm outcomesChimney techniqueAortic dissectionSubclavian arteryImmediate type Ia endoleakRight upper extremity weaknessDouble chimney techniqueMean preoperative diameterPreoperative imaging examinationUpper extremity weaknessType Ia endoleakDominant vertebral arterySpinal cord ischemiaEndovascular aortic repairMean procedural timeCerebral blood flowTotal endovascular repair
2018
Atorvastatin regulates pericardial patch healing via the microRNA140-ADAM10-ephrinB2 pathway.
Li X, Dardik A, Guo R, Zhang W, Xiang Y, Li S, Liu D, Shu C. Atorvastatin regulates pericardial patch healing via the microRNA140-ADAM10-ephrinB2 pathway. American Journal Of Translational Research 2018, 10: 4054-4064. PMID: 30662650, PMCID: PMC6325491.Peer-Reviewed Original ResearchPericardial patch angioplastyDose-dependent mannerPatch angioplastyPericardial patchMRNA expressionMiR-140 expressionADAM10 protein expressionDaily doseCardiovascular injuryVascular proceduresVascular surgeryEndothelium repairWistar ratsNeointimal formationNeointimal growthControl animalsEarly healingAtorvastatinCardiovascular systemStatin drugsWestern blotEphrinB2 expressionEphrinB2 mRNAProtein expressionAngioplasty