2024
Improving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial
Puklin L, Ferrucci L, Harrigan M, McGowan C, Zupa M, Cartmel B, Li F, Ligibel J, Spiegelman D, Sharifi M, Sanft T, Irwin M. Improving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial. Cancer 2024, 130: 2440-2452. PMID: 38470431, PMCID: PMC11214600, DOI: 10.1002/cncr.35280.Peer-Reviewed Original ResearchPhysical activityDiet qualityHEI-2015Strength trainingLifestyle behaviorsHealthy Eating Index (HEI)-2015Breast cancerAssociated with baseline fatigueImprove physical activityImprove lifestyle behaviorsHigher HEI-2015Associated with higher oddsExercise interventionUsual careIntervention armIntervention groupBaseline fatigueLifestyle interventionYearlong interventionLower fatigueHigher oddsSecondary analysisLogistic regressionNewly diagnosed patientsStudy arms
2023
Post-diagnosis weight trajectories and mortality among women with breast cancer
Puklin L, Li F, Cartmel B, Zhao J, Sanft T, Lisevick A, Winer E, Lustberg M, Spiegelman D, Sharifi M, Irwin M, Ferrucci L. Post-diagnosis weight trajectories and mortality among women with breast cancer. Npj Breast Cancer 2023, 9: 98. PMID: 38042922, PMCID: PMC10693588, DOI: 10.1038/s41523-023-00603-5.Peer-Reviewed Original ResearchBody mass indexBreast cancer diagnosisWeight changeCause mortalityClinical characteristicsWeight gainWeight lossBreast cancerWeight trajectoriesPost-diagnosis weight changeBreast cancer-specific mortalityCox proportional hazards modelModern treatment eraCancer-specific mortalityCancer diagnosisModerate weight lossModerate weight gainProportional hazards modelAdverse health outcomesElectronic health recordsTreatment eraBaseline characteristicsTumor RegistryMass indexWeight management