2024
Severe Sepsis During Treatment for Childhood Leukemia and Sequelae Among Adult Survivors
Goggin K, Lu L, Lee D, Howell C, Srivastava D, Brinkman T, Armstrong G, Bhakta N, Robison L, Ehrhardt M, Hudson M, Krull K, Pui C, Rubnitz J, Ness K, Wolf J. Severe Sepsis During Treatment for Childhood Leukemia and Sequelae Among Adult Survivors. JAMA Network Open 2024, 7: e242727. PMID: 38497960, PMCID: PMC10949094, DOI: 10.1001/jamanetworkopen.2024.2727.Peer-Reviewed Original ResearchConceptsChronic health conditionsHealth conditionsAdult survivorsCohort studyAdult survivors of childhood cancerSt Jude Lifetime Cohort StudyIncidence of chronic health conditionsChildhood leukemiaSurvivors of childhood cancerAssociated with long-term riskIncreased riskMedical record reviewQuality of lifeInverse propensity score weightingAdult survivors of childhood leukemiaYear of diagnosisCancer survivorsSevere sepsisPropensity score weightingSurvivors of childhood leukemiaMain OutcomesPotential confoundersChildhood cancerRecord reviewLong-term risk
2023
Prediabetes and Associated Risk of Cardiovascular Events and Chronic Kidney Disease Among Adult Survivors of Childhood Cancer in the St Jude Lifetime Cohort
Dixon S, Wang F, Lu L, Wilson C, Green D, Merchant T, Srivastava D, Delaney A, Howell R, Jefferies J, Robison L, Ness K, Hudson M, Chemaitilly W, Armstrong G. Prediabetes and Associated Risk of Cardiovascular Events and Chronic Kidney Disease Among Adult Survivors of Childhood Cancer in the St Jude Lifetime Cohort. Journal Of Clinical Oncology 2023, 42: 1031-1043. PMID: 38091552, PMCID: PMC10950176, DOI: 10.1200/jco.23.01005.Peer-Reviewed Original ResearchConceptsChronic kidney diseasePrevalence of prediabetesRisk of cardiovascular eventsAdult survivors of childhood cancerSurvivors of childhood cancerIncreased riskCardiovascular eventsKidney diseaseRisk of future cardiac eventsAssociated with radiation exposureTotal body irradiationRisk of progressionChildhood cancerCox proportional hazards regressionSt Jude Lifetime CohortFuture cardiac eventsPrevent subsequent morbidityProportional hazards regressionModifiable risk factorsNormal glucose controlAdult survivorsLongitudinal follow-upChildhood cancer diagnosisPrediabetes to diabetesMedian age