2022
Optimization of FLASH proton beams using a track‐repeating algorithm
Wang Q, Titt U, Mohan R, Guan F, Zhao Y, Yang M, Yepes P. Optimization of FLASH proton beams using a track‐repeating algorithm. Medical Physics 2022, 49: 6684-6698. PMID: 35900902, DOI: 10.1002/mp.15849.Peer-Reviewed Original Research
2021
Uncertainty in tissue equivalent proportional counter assessments of microdosimetry and RBE estimates in carbon radiotherapy
Hartzell S, Guan F, Taylor P, Peterson C, Taddei P, Kry S. Uncertainty in tissue equivalent proportional counter assessments of microdosimetry and RBE estimates in carbon radiotherapy. Physics In Medicine And Biology 2021, 66: 155018. PMID: 34252894, DOI: 10.1088/1361-6560/ac1366.Peer-Reviewed Original ResearchConceptsTissue equivalent proportional counterCommon mathematical modelPerturbed valuesMicrodosimetric kinetic modelLow-energy cutMonte Carlo toolkitMathematical modelCounting statisticsCentral beam axisEnergy deposition distributionsStatistic uncertaintyInput parametersTherapeutic carbon beamsLineal energy valuesCarbon beamBeam axisTEPC measurementsSources of uncertaintyWall effectsModel input parametersMicrodosimetric spectraInherent uncertaintyRelative biological effectivenessUncertaintyCarbon radiotherapyMonte Carlo simulation of pixelated CZT detector with Geant4: validation of clinical molecular breast imaging system
Lopez BP, Guan F, Rauch GM, Kappadath SC. Monte Carlo simulation of pixelated CZT detector with Geant4: validation of clinical molecular breast imaging system. Physics In Medicine And Biology 2021, 66: 125009. PMID: 34038878, DOI: 10.1088/1361-6560/ac0588.Peer-Reviewed Original ResearchConceptsCharge transportPerformance characteristicsCZT detectorsModel parametersTwo-step processBreast imaging systemOverall energy spectrumMonte Carlo simulation applicationsSpatial resolutionAirBreast phantomGood agreementMATLAB scriptImaging systemResponse model parametersSimulation applicationsSimulationsEnergy spectrumMonte Carlo simulationsTc pointFinal model parametersTelluride detectorSource geometryStandard performance characteristicsFWHMEffect of spatial distribution of boron and oxygen concentration on DNA damage induced from boron neutron capture therapy using Monte Carlo simulations
Qi J, Geng C, Tang X, Tian F, Han Y, Liu H, Liu Y, Bortolussi S, Guan F. Effect of spatial distribution of boron and oxygen concentration on DNA damage induced from boron neutron capture therapy using Monte Carlo simulations. International Journal Of Radiation Biology 2021, 97: 986-996. PMID: 33970761, DOI: 10.1080/09553002.2021.1928785.Peer-Reviewed Original Research
2020
Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns
Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Scientific Reports 2020, 10: 3199. PMID: 32081928, PMCID: PMC7035246, DOI: 10.1038/s41598-020-60246-5.Peer-Reviewed Original ResearchConceptsIntensity-modulated proton therapyLow-energy beamsIntensity modulation patternCurrent treatment planProton therapyBiological effectsDelivery strategiesTarget doseTherapeutic indexTreatment planHigh-energy beamsEffective doseEnhanced biological effectClinical potentialTherapyCancer cellsDoseBragg peak
2019
A Monte Carlo study of pinhole collimated Cerenkov luminescence imaging integrated with radionuclide treatment
Geng C, Ai Y, Tang X, Shu D, Gong C, Guan F. A Monte Carlo study of pinhole collimated Cerenkov luminescence imaging integrated with radionuclide treatment. Physical And Engineering Sciences In Medicine 2019, 42: 481-487. PMID: 30830649, DOI: 10.1007/s13246-019-00744-7.Peer-Reviewed Original ResearchUsing the Proton Energy Spectrum and Microdosimetry to Model Proton Relative Biological Effectiveness
Newpower M, Patel D, Bronk L, Guan F, Chaudhary P, McMahon SJ, Prise KM, Schettino G, Grosshans DR, Mohan R. Using the Proton Energy Spectrum and Microdosimetry to Model Proton Relative Biological Effectiveness. International Journal Of Radiation Oncology • Biology • Physics 2019, 104: 316-324. PMID: 30731186, PMCID: PMC6499683, DOI: 10.1016/j.ijrobp.2019.01.094.Peer-Reviewed Original ResearchMeSH KeywordsLinear Energy TransferMonte Carlo MethodProton TherapyProtonsRadiotherapy DosageRelative Biological EffectivenessConceptsProton energy spectraMicrodosimetric kinetic modelDose-mean lineal energyRelative biological effectivenessProton irradiation experimentsEnergy spectrumLineal energyLineal energy yIrradiation experimentsLineal energy distributionsDose-averaged linear energy transferBiological effectivenessDifferent proton energiesLinear energy transferRBE modelsProton energyBragg curveEnergy distributionGeant4-DNAProton irradiationRBE data
2018
A mechanistic relative biological effectiveness model-based biological dose optimization for charged particle radiobiology studies
Guan F, Geng C, Carlson DJ, H D, Bronk L, Gates D, Wang X, Kry SF, Grosshans D, Mohan R. A mechanistic relative biological effectiveness model-based biological dose optimization for charged particle radiobiology studies. Physics In Medicine And Biology 2018, 64: 015008. PMID: 30523805, DOI: 10.1088/1361-6560/aaf5df.Peer-Reviewed Original ResearchPhysical parameter optimization scheme for radiobiological studies of charged particle therapy
Geng C, Gates D, Bronk L, Ma D, Guan F. Physical parameter optimization scheme for radiobiological studies of charged particle therapy. Physica Medica 2018, 51: 13-21. PMID: 30278981, PMCID: PMC6173200, DOI: 10.1016/j.ejmp.2018.06.001.Peer-Reviewed Original ResearchMeSH KeywordsHeavy Ion RadiotherapyLinear Energy TransferMonte Carlo MethodProton TherapyRadiobiologyRelative Biological EffectivenessConceptsIon beamParticle therapyPhysical quantitiesDose-averaged linear energy transferC-ion beamsLinear energy transferBiological dose optimizationParticle beamsProton beamBragg curveBragg peakWhole target regionBeamCorresponding physical dataEnergy transferProtonsMonte Carlo simulationsAppropriate biophysical modelSpatial distributionSOBPRadiobiological studiesCarlo simulationsDose spreadIonsLETInvestigation of the dose perturbation effect for therapeutic beams with the presence of a 1.5 T transverse magnetic field in magnetic resonance imaging-guided radiotherapy.
Shao W, Tang X, Bai Y, Shu D, Geng C, Gong C, Guan F. Investigation of the dose perturbation effect for therapeutic beams with the presence of a 1.5 T transverse magnetic field in magnetic resonance imaging-guided radiotherapy. Journal Of Cancer Research And Therapeutics 2018, 14: 184-195. PMID: 29516984, DOI: 10.4103/jcrt.jcrt_1349_16.Peer-Reviewed Original ResearchConceptsT transverse magnetic fieldBeam energyCarbon ion beamsTherapeutic beamTransverse magnetic fieldMagnetic fieldDose perturbationsDose perturbation effectsIon beamMagnetic resonance imaging-guided radiotherapyHigher beam energiesUniform magnetic fieldWater-air interfaceAir-tissue interfacePhoton beamsRadiation fieldPerturbation effectsBragg peakProper energyBeamBeam typeDose distributionEnergyProtonsRadiotherapy methods
2017
Optimization of Monte Carlo particle transport parameters and validation of a novel high throughput experimental setup to measure the biological effects of particle beams
Patel D, Bronk L, Guan F, Peeler CR, Brons S, Dokic I, Abdollahi A, Rittmüller C, Jäkel O, Grosshans D, Mohan R, Titt U. Optimization of Monte Carlo particle transport parameters and validation of a novel high throughput experimental setup to measure the biological effects of particle beams. Medical Physics 2017, 44: 6061-6073. PMID: 28880368, DOI: 10.1002/mp.12568.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TumorHumansMonte Carlo MethodRadiometryRelative Biological EffectivenessUncertainty
2016
Monte Carlo simulations of 3He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness
Taleei R, Guan F, Peeler C, Bronk L, Patel D, Mirkovic D, Grosshans DR, Mohan R, Titt U. Monte Carlo simulations of 3He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness. Medical Physics 2016, 43: 761-776. PMID: 26843239, DOI: 10.1118/1.4939440.Peer-Reviewed Original ResearchMeSH KeywordsCell DeathHeliumIsotopesMonte Carlo MethodPhantoms, ImagingRelative Biological EffectivenessWaterConceptsMonte Carlo codeEnergy depositionCarlo codeLineal energyEnergy distributionRadiation beam qualitiesSecondary particle productionDifferent Monte Carlo codesDepth dose curvesPrimary beam parametersGaussian energy distributionMonte Carlo systemHelium ionsBeam qualityMicrodosimetric parametersMonte Carlo methodBeam parametersEnergy spectrumIncident beamBragg curveRadiobiological effectivenessBragg peakHalf maximumProton doseFull width
2015
A Monte Carlo-based radiation safety assessment for astronauts in an environment with confined magnetic field shielding
Geng C, Tang X, Gong C, Guan F, Johns J, Shu D, Chen D. A Monte Carlo-based radiation safety assessment for astronauts in an environment with confined magnetic field shielding. Journal Of Radiological Protection 2015, 35: 777-788. PMID: 26484984, DOI: 10.1088/0952-4746/35/4/777.Peer-Reviewed Original ResearchConceptsGalactic cosmic radiationSolar particle eventsMagnetic fieldActive shielding techniqueToroidal magnetic fieldMonte Carlo toolkitMagnetic field strengthGCR particlesParticle eventsCosmic radiationParticle fluenceSPE protonsRadiation fieldMonte CarloPassive shielding techniquesField strengthDose equivalentAdditional shieldingShielding techniqueRadiation safety assessmentActive shieldingAnthropomorphic phantomRadiation protectionFieldShieldingAnalysis of the track‐ and dose‐averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code
Guan F, Peeler C, Bronk L, Geng C, Taleei R, Randeniya S, Ge S, Mirkovic D, Grosshans D, Mohan R, Titt U. Analysis of the track‐ and dose‐averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code. Medical Physics 2015, 42: 6234-6247. PMID: 26520716, PMCID: PMC4600086, DOI: 10.1118/1.4932217.Peer-Reviewed Original ResearchCalculations of S values and effective dose for the radioiodine carrier and surrounding individuals based on Chinese hybrid reference phantoms using the Monte Carlo technique
Geng C, Tang X, Qian W, Guan F, Johns J, Yu H, Gong C, Shu D, Chen D. Calculations of S values and effective dose for the radioiodine carrier and surrounding individuals based on Chinese hybrid reference phantoms using the Monte Carlo technique. Journal Of Radiological Protection 2015, 35: 707-717. PMID: 26344387, DOI: 10.1088/0952-4746/35/3/707.Peer-Reviewed Original ResearchGEANT4 calculations of neutron dose in radiation protection using a homogeneous phantom and a Chinese hybrid male phantom
Geng C, Tang X, Guan F, Johns J, Vasudevan L, Gong C, Shu D, Chen D. GEANT4 calculations of neutron dose in radiation protection using a homogeneous phantom and a Chinese hybrid male phantom. Radiation Protection Dosimetry 2015, 168: 433-440. PMID: 26156875, DOI: 10.1093/rpd/ncv364.Peer-Reviewed Original ResearchMeSH KeywordsComputer SimulationHumansMaleMonte Carlo MethodNeutronsPhantoms, ImagingRadiation DosageRadiation ProtectionRadiometryConceptsNeutron dose calculationsDepth dose distributionsHomogeneous phantomThermal energy rangeS-matrix correctionsClose simulation resultsPhysics listsGeant4 calculationsNeutron energyEnergy rangeThermal scatteringNeutron doseRadiation protectionGeant4Conversion coefficientsMCNP5Dose conversion coefficientsDose distributionDose calculationsMatrix correctionMale phantomPhantomCalculationsEnergyFluenceA Novel Algorithm for Solving the True Coincident Counting Issues in Monte Carlo Simulations for Radiation Spectroscopy
Guan F, Johns JM, Vasudevan L, Zhang G, Tang X, Poston JW, Braby LA. A Novel Algorithm for Solving the True Coincident Counting Issues in Monte Carlo Simulations for Radiation Spectroscopy. Health Physics 2015, 108: 574-579. PMID: 25905518, DOI: 10.1097/hp.0000000000000185.Peer-Reviewed Original ResearchConceptsHigh-purity germanium detectorDetection efficiencyRadiation spectroscopyGermanium detectorCoincident countsGeant4 Monte Carlo simulation toolkitSimulated pulse height spectraMonte Carlo simulation toolkitPulse height spectraRadiation fieldRadiation sourceCoincident radiationNuclear fissionHeight spectraMonte Carlo methodSource particlesSimulation toolkitSpectroscopy problemsMonte Carlo simulationsDetectorCarlo methodCarlo simulationsSpectroscopySpectraNuclear fuelSpatial mapping of the biologic effectiveness of scanned particle beams: towards biologically optimized particle therapy
Guan F, Bronk L, Titt U, Lin SH, Mirkovic D, Kerr MD, Zhu XR, Dinh J, Sobieski M, Stephan C, Peeler CR, Taleei R, Mohan R, Grosshans DR. Spatial mapping of the biologic effectiveness of scanned particle beams: towards biologically optimized particle therapy. Scientific Reports 2015, 5: 9850. PMID: 25984967, PMCID: PMC4650781, DOI: 10.1038/srep09850.Peer-Reviewed Original Research